[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100574962":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":30,"centralContacts":35,"locations":40,"responsibleParty":60,"collaborators":26,"id":64,"slug":65,"hasResults":66,"nctId":67,"briefTitle":68,"officialTitle":69,"acronym":26,"eligibilityCriteria":70,"healthyVolunteers":71,"sex":72,"minAge":73,"maxAge":74,"enrollmentInfo":75,"targetDuration":26,"studyType":78,"phases":79,"briefSummary":81,"conditions":82,"keywords":85,"overallStatus":88,"whyStopped":26,"lastUpdateSubmitDate":89,"lastUpdatePostDateStruct":90,"startDateStruct":93,"completionDateStruct":95,"leadSponsor":97,"locationsCount":98},{"fullName":5,"class":6},"University of Athens","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Experimental group Mastic toothpaste","EXPERIMENTAL","Experimental Group: patients, age 13-18, conventional brackets, Mastiha toothpaste 15 patients, with conventional brackets",[13],"Dietary Supplement: mastic toothpaste",{"label":15,"type":16,"description":17,"interventionNames":18},"Placebo control arm: placebo toothpaste","PLACEBO_COMPARATOR","Control Group: patients, age 13-18, conventional brackets, Placebo toothpaste 15 patients, with conventional brackets",[19],"Dietary Supplement: Placebo toothpaste",[21,27],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"DIETARY_SUPPLEMENT","mastic toothpaste","All 30 patients will be randomly assigned to either the mastic toothpaste group A (Mastiha Toothpaste Gingivaction, Mastihashop, Greece) (n = 15) or the placebo Toothpaste group B (from the same manufacturer) (n = 15). All patients will be asked to use the toothpaste triple a day for 14 days and to maintain their usual oral hygiene routine. The measurements will be done in the morning and at least three hours after brushing and without the use of the toothpaste by the participant on the day of the assessments.",[9],null,{"type":22,"name":28,"description":24,"armGroupLabels":29,"otherNames":26},"Placebo toothpaste",[15],[31],{"name":32,"affiliation":33,"role":34},"Iosif Sifakakis, Associate Professor","National and Kapodistrian Univrsity of Athens Greece","STUDY_DIRECTOR",[36],{"name":32,"role":37,"phone":38,"phoneExt":26,"email":39},"CONTACT","+302107461228","isifak@dent.uoa.gr",[41],{"facility":42,"status":26,"city":43,"state":44,"zip":45,"country":46,"countryCode":47,"cosmosGeoPoint":48,"geoPoint":53,"contacts":54},"School of Dentistry","Athens","Attica","11527","Greece","GR",{"type":49,"coordinates":50},"Point",[51,52],23.72784,37.98376,{"lat":52,"lon":51},[55,57],{"name":32,"role":37,"phone":56,"phoneExt":26,"email":39},"+302107461337",{"name":58,"role":37,"phone":38,"phoneExt":26,"email":59},"Mairi Papadopoulou, Secretary","mapapad@dent.uoa.gr",{"type":61,"investigatorFullName":62,"investigatorTitle":63,"investigatorAffiliation":5,"oldNameTitle":26,"oldOrganization":26},"PRINCIPAL_INVESTIGATOR","Iosif Sifakakis","Associate Professor","100574962","chios-mastic-toothpaste-and-halitosis-and-oral-hygiene-in-orthodontic-patients-100574962",false,"NCT06766097","Chios Mastic Toothpaste and Halitosis and Oral Hygiene in Orthodontic Patients","The Effect of Chios' Mastic Toothpaste on Halitosis and Oral Hygiene in Orthodontic Patients: a Randomized Clinical Trial","Inclusion Criteria:\n\nPatients eligible for the trial must comply with all of the following at randomization:\n\n• Age between 13 and 18 years for the group with conventional orthodontic appliances.\n\nThis age group represents the majority of patients seeking orthodontic treatment and is homogeneous regarding occupational status (high-school and lyceum students in Greece). Younger patients might present with cooperation problems.\n\n* Good general health.\n* Orthodontic fixed labial appliances on the maxillary and mandibular arch, brackets at least on 20 teeth for more than 4 months before enrollment and estimated duration of the treatment more than 1 month, bands on the first molars, extraction cases patients could be enrolled at least two months after the last extraction.\n* Total initial VSCs levels above the baseline level of 150ppb.\n\nExclusion Criteria:\n\nPatients will be excluded for any of the following reasons:\n\n* Active caries\n* Periodontitis\n* Dental fluorosis \u002F dysplasia of the teeth\n* Syndromes, mental disabilities and craniofacial deformities\n* Smoking or use of other tobacco products\n* Allergy to mastic\n* Antibiotics during the last 2 months\n* Chlorhexidine in the previous 3 weeks\n* Participation in other trials",true,"ALL","13 Years","18 Years",{"count":76,"type":77},30,"ESTIMATED","INTERVENTIONAL",[80],"NA","The aim of this trial was to investigate the effect of mastic toothpaste on halitosis using as proxy the levels of the Volatile Sulfur Compounds (VSCs), and the effect on plaque and gingival indices in adolescents undergoing orthodontic treatment with fixed conventional labial appliances.",[83,84],"Halitosis","Orthodontic Appliance Complication",[83,86,87],"Mastic","Orthodontic appliance","NOT_YET_RECRUITING","2025-01-03",{"date":91,"type":92},"2025-01-09","ACTUAL",{"date":94,"type":77},"2025-01-07",{"date":96,"type":77},"2025-02-28",{"name":5,"class":6},1]