[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100629046":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":30,"centralContacts":34,"locations":25,"responsibleParty":40,"collaborators":43,"id":46,"slug":47,"hasResults":48,"nctId":49,"briefTitle":50,"officialTitle":51,"acronym":25,"eligibilityCriteria":52,"healthyVolunteers":48,"sex":53,"minAge":54,"maxAge":55,"enrollmentInfo":56,"targetDuration":25,"studyType":59,"phases":60,"briefSummary":62,"conditions":63,"keywords":65,"overallStatus":71,"whyStopped":25,"lastUpdateSubmitDate":72,"lastUpdatePostDateStruct":73,"startDateStruct":76,"completionDateStruct":78,"leadSponsor":80,"locationsCount":25},{"fullName":5,"class":6},"Brigham and Women's Hospital","OTHER",[8,15],{"label":9,"type":10,"description":11,"interventionNames":12},"Multimodal chiropractic care","EXPERIMENTAL","10 visits over 16 weeks including spinal manipulation\u002Fmobilization, soft tissue therapy, exercise, and education.\n\nParticipants receive 10 visits of multimodal chiropractic care over 16 weeks in addition to enhanced usual care. Care may include spinal manipulation or mobilization, soft tissue therapy, therapeutic exercise, and education delivered by licensed chiropractors.",[13,14],"Procedure: Multimodal chiroprctic care","Behavioral: Enahnced usual care",{"label":16,"type":17,"description":18,"interventionNames":19},"Enhanced usual care","ACTIVE_COMPARATOR","Educational materials, usual medical care, biweekly check-in calls.\n\nParticipants continue their usual medical care and receive educational materials for neck pain self-management and biweekly check-in calls from study staff.",[14],[21,26],{"type":22,"name":23,"description":11,"armGroupLabels":24,"otherNames":25},"PROCEDURE","Multimodal chiroprctic care",[9],null,{"type":27,"name":28,"description":18,"armGroupLabels":29,"otherNames":25},"BEHAVIORAL","Enahnced usual care",[16,9],[31],{"name":32,"affiliation":5,"role":33},"Peter Wayne, PhD","PRINCIPAL_INVESTIGATOR",[35],{"name":36,"role":37,"phone":38,"phoneExt":25,"email":39},"Macy Randolph, DC","CONTACT","617-732-6271","pwayne@bwh.harvard.edu",{"type":33,"investigatorFullName":41,"investigatorTitle":42,"investigatorAffiliation":5,"oldNameTitle":25,"oldOrganization":25},"Peter M. Wayne, Ph.D.","Director, Osher Center for Integrative Health",[44],{"name":45,"class":6},"Palmer College of Chiropractic","100629046","chiropractic-care-for-chronic-neck-pain-a-pilot-study-100629046",false,"NCT07469553","Chiropractic Care for Chronic Neck Pain: A Pilot Study","Chiropractic Care for Chronic Neck Pain: A Pilot Randomized Controlled Trial Evaluating Feasibility, Clinical Outcomes, and EEG\u002FGait Biomarkers","Inclusion Criteria:\n\nAdults aged 18-65 years Diagnosis of CNP (e.g., nociceptive, neuropathic, or nociplastic origin) occurring ≥5 days per week for ≥3 consecutive months.\n\nAverage neck pain intensity ≥3 on a 0-10 Numerical Rating Scale (NRS) during the past week (0 = no pain at all; 10 = worst neck pain imaginable).\n\nNeck Disability Index (NDI) score ≥5 \\[37\\] 10-item instrument with scores ranging from 0 (no disability) to 50 (complete disability).\n\nWillingness to complete all study procedures. Willingness to be randomized to either of the two intervention groups. Fluent in English.\n\nExclusion Criteria:\n\n* Currently receiving chiropractic care or have received chiropractic care within the past 12 months.\n\nParticipation in ≥1 session per week of mind-body or rehabilitation therapies (e.g., physical therapy, yoga, tai chi, Qigong) within the past 12 months.\n\nAny disability precluding exercise participation. Pregnancy. Pregnancy status will be assessed by self-report only. No pregnancy testing will be conducted for the purposes of this study.\n\nPrior cervical spine surgery or any spinal surgery within the past year. Active disability or accident-related compensation claim. Signs or symptoms of major systemic illness or unstable medical conditions (e.g., Parkinson's disease, cancer).\n\nPsychiatric conditions requiring immediate treatment or likely to impair protocol compliance.\n\nCNP attributable to on-neuromusculoskeletal source. Inflammatory arthritis. History of stroke, carotid dissection, or vertebral artery dissection. Presence of a neurological disorder. Suspected or confirmed pathological hypermobility. Receipt of interventional pain management to the cervical spine within 4 weeks prior to enrollment or planned during the study period.\n\nAvailable diagnostic imaging demonstrating contraindications to study treatments (e.g., cervical myelopathy, substantial disc derangement).\n\nClinical screening findings indicating a need for diagnostic imaging. High risk for adverse events (AEs) related to any study treatment. Inadequate transportation to attend scheduled study visits. Contraindications to standard, non-invasive scalp EEG procedures (e.g., open scalp wounds, active skin infections, or unhealed surgical sites at electrode placement locations; recent craniotomy or skull defect that would interfere with safe electrode placement, Implanted neurostimulation devices; known seizure disorders or epilepsy; medical conditions for which EEG activation procedures are contraindicated (stroke, hyperventilation).","ALL","18 Years","65 Years",{"count":57,"type":58},60,"ESTIMATED","INTERVENTIONAL",[61],"NA","This pilot randomized controlled trial will evaluate the feasibility and preliminary clinical effects of multimodal chiropractic care for adults with chronic neck pain. Forty participants will be randomized to receive either multimodal chiropractic care plus enhanced usual care or enhanced usual care alone. Feasibility outcomes include recruitment, retention, adherence, and safety. Clinical outcomes include pain intensity, neck-related disability, physical and psychological function, and quality of life. Exploratory electroencephalography (EEG) and gait assessments will examine potential neurophysiological and biomechanical biomarkers associated with treatment response.",[64],"Neck Pain",[66,67,68,69,70],"neck pain","chiropractic care","EEG","gait","randomized trial","NOT_YET_RECRUITING","2026-06-24",{"date":74,"type":75},"2026-06-26","ACTUAL",{"date":77,"type":58},"2026-08-01",{"date":79,"type":58},"2027-09-30",{"name":5,"class":6}]