[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100608665":3},{"organization":4,"armGroups":7,"interventions":14,"overallOfficials":10,"centralContacts":20,"locations":10,"responsibleParty":26,"collaborators":10,"id":30,"slug":31,"hasResults":32,"nctId":33,"briefTitle":34,"officialTitle":35,"acronym":10,"eligibilityCriteria":36,"healthyVolunteers":32,"sex":37,"minAge":38,"maxAge":39,"enrollmentInfo":40,"targetDuration":10,"studyType":43,"phases":10,"briefSummary":44,"conditions":45,"keywords":48,"overallStatus":51,"whyStopped":10,"lastUpdateSubmitDate":52,"lastUpdatePostDateStruct":53,"startDateStruct":56,"completionDateStruct":58,"leadSponsor":60,"locationsCount":10},{"fullName":5,"class":6},"Assiut University","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"Children with Congenital Heart Disease",null,"This cohort includes pediatric patients with a confirmed diagnosis of congenital heart disease (CHD) attending Assiut University Children's Hospital and Elmabara Insurance Hospital. All participants underwent clinical evaluation, dysmorphic feature assessment, and cytogenetic testing (karyotyping) to detect chromosomal abnormalities. No therapeutic interventions were applied as part of this study; data were collected for observational and genetic analysis purposes only.",[13],"Diagnostic Test: Conventional Karyotyping",[15],{"type":16,"name":17,"description":18,"armGroupLabels":19,"otherNames":10},"DIAGNOSTIC_TEST","Conventional Karyotyping","Conventional chromosomal analysis was performed using karyotyping of peripheral blood lymphocytes. Standard cytogenetic techniques were applied to identify chromosomal abnormalities in pediatric patients with congenital heart disease. This diagnostic test was used solely for observational and genetic correlation purposes.",[9],[21],{"name":22,"role":23,"phone":24,"phoneExt":10,"email":25},"Alyaa Ramadan Ibrahim, resident","CONTACT","01004231328","ramadanalyaa58@gmail.com",{"type":27,"investigatorFullName":28,"investigatorTitle":29,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"PRINCIPAL_INVESTIGATOR","Alyaa Ramadan Ibrahim","Resident, pediatrics Department","100608665","chromosomal-abnormalities-in-patients-with-congenital-heart-disease-at-assiut-university-childrens-hospital-100608665",false,"NCT07204509","Chromosomal Abnormalities in Patients With Congenital Heart Disease at Assiut University Children's Hospital","Incidence of Chromosomal Abnormalities in Patients With Congenital Heart Diseases Attending Assiut University Children's Hospital","Inclusion Criteria:\n\n* Children with a confirmed diagnosis of congenital heart disease (by echocardiography and\u002For cardiology evaluation).\n* Age between 1 month and 18 years.\n* Patients attending Assiut University Children's Hospital or Elmabara Insurance Hospital during the study period.\n* Informed consent obtained from parents or legal guardians.\n\nExclusion Criteria:\n\n* Patients with acquired (non-congenital) heart disease.\n* Critically ill patients in unstable condition not suitable for blood sampling.\n* Incomplete clinical data or refusal of parents\u002Fguardians to participate.","ALL","1 Month","18 Years",{"count":41,"type":42},138,"ESTIMATED","OBSERVATIONAL","Congenital heart disease (CHD) is one of the most common birth defects and an important cause of infant morbidity and mortality. Many children with CHD also have underlying genetic abnormalities, particularly chromosomal abnormalities, which may affect their prognosis, management, and counseling. This study aims to determine the incidence and pattern of chromosomal abnormalities among children with CHD attending Assiut University Children's Hospital and Elmabara Insurance Hospital.\n\nChildren with a confirmed diagnosis of CHD will undergo a detailed clinical assessment, including dysmorphic evaluation, followed by chromosomal analysis (karyotyping). The study will help identify the frequency and type of chromosomal abnormalities associated with CHD and their correlation with specific cardiac defects and phenotypic features.\n\nUnderstanding these genetic associations may improve diagnosis, early intervention, and family counseling, and provide useful information for risk stratification and prevention strategies in the Egyptian population.",[46,47],"Congenital Heart Disease (CHD)","Chromosomal Abnormalities",[49,50],"Karyotyping","gentic disease","NOT_YET_RECRUITING","2025-09-25",{"date":54,"type":55},"2025-10-02","ACTUAL",{"date":57,"type":42},"2025-10-01",{"date":59,"type":42},"2026-12-01",{"name":5,"class":6}]