[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100567680":3},{"organization":4,"armGroups":7,"interventions":14,"overallOfficials":21,"centralContacts":25,"locations":33,"responsibleParty":48,"collaborators":20,"id":51,"slug":52,"hasResults":53,"nctId":54,"briefTitle":55,"officialTitle":56,"acronym":20,"eligibilityCriteria":57,"healthyVolunteers":53,"sex":58,"minAge":59,"maxAge":60,"enrollmentInfo":61,"targetDuration":20,"studyType":64,"phases":65,"briefSummary":67,"conditions":68,"keywords":71,"overallStatus":75,"whyStopped":20,"lastUpdateSubmitDate":76,"lastUpdatePostDateStruct":77,"startDateStruct":80,"completionDateStruct":82,"leadSponsor":84,"locationsCount":85},{"fullName":5,"class":6},"Chinese University of Hong Kong","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"IH\u002FT2D","EXPERIMENTAL","partipiants with intermediate hyperglycemia (IH) n=15 or T2D (n=15)",[13],"Drug: Dorzagliatin",[15],{"type":16,"name":17,"description":18,"armGroupLabels":19,"otherNames":20},"DRUG","Dorzagliatin","chronic treatment with dorzagliatin for 4 weeks (50mg twice daily or 75mg twice daily, oral)",[9],null,[22],{"name":23,"affiliation":5,"role":24},"Elaine Chow, MBChB, PhD, FRCP","PRINCIPAL_INVESTIGATOR",[26,31],{"name":27,"role":28,"phone":29,"phoneExt":20,"email":30},"Elaine Chow","CONTACT","+852 35051641","e.chow@cuhk.edu.hk",{"name":27,"role":28,"phone":32,"phoneExt":20,"email":20},"+852 35051642",[34],{"facility":35,"status":20,"city":36,"state":20,"zip":20,"country":36,"countryCode":37,"cosmosGeoPoint":38,"geoPoint":43,"contacts":44},"Phase 1 Clinical Trial Centre","Hong Kong","HK",{"type":39,"coordinates":40},"Point",[41,42],114.17469,22.27832,{"lat":42,"lon":41},[45],{"name":46,"role":28,"phone":29,"phoneExt":20,"email":47},"Michelle Wong","michellewong27@cuhk.edu.hk",{"type":49,"investigatorFullName":27,"investigatorTitle":50,"investigatorAffiliation":5,"oldNameTitle":20,"oldOrganization":20},"SPONSOR_INVESTIGATOR","Clinical Associate Professor","100567680","chronic-dorzagliatin-on-insulin-and-incretin-function-in-intermediate-hyperglycemia-and-type-2-diabetes-100567680",false,"NCT06671340","Chronic Dorzagliatin on Insulin and Incretin Function in Intermediate Hyperglycemia and Type 2 Diabetes","Effects of Repeated Dose of Dorzagliatin on Insulin Secretion, Glucagon Release and Incretin Function in Intermediate Hyperglycemia and Type 2 Diabetes","Inclusion Criteria:\n\n1. Individuals aged ≥ 18 years but \\\u003C 70 years\n2. Male or female\n3. Body mass index of over 18 kg\u002Fm2 and \\\u003C 35 kg\u002Fm2\n\nAdditional inclusion criteria for IH group\n\n* Fasting plasma glucose \\\u003C7.0 mmol\u002FL and HbA1c \\\u003C 6.5%\n* 1 hour plasma glucose ≥8.6 and \\\u003C11.6 mmol\u002FL on 75g oral glucose tolerance test (OGTT)\n* No use of glucose lowering drugs in past 6 months\n\nAdditional inclusion criteria for T2D group\n\n* HbA1c 6.5 to 10% at screening\n* On diet control, or stable dose of oral glucose lowering drugs metformin for at least 8 weeks\n\nExclusion Criteria:\n\n* 1\\. Subjects who do not agree to participate in this study. 2. Country of birth is unknown. 3. Body weight less than 45kg. 4. Acute phase of cerebrovascular and cardiovascular diseases (within 6 months of recruitment).\n\n  5\\. Subjects with severe renal dysfunction as defined by eGFR \\\u003C30 ml\u002Fmin\u002F1.73m2 or patients receiving renal dialysis (such as haemodialysis or continuous ambulatory peritoneal dialysis).\n\n  6\\. Severe hepatic dysfunction as defined by aspartate aminotransferase (AST) and\u002For alanine aminotransferase (ALT) \\> 3 times upper limit of normal.\n\n  7\\. Severe cardiovascular disease, history of stroke, heart failure (NYHA III or IV) or history of myocardial infarction within last 12 months.\n\n  8\\. History of drug abuse or excessive alcohol intake based on investigator judgment.\n\n  9\\. Dehydration, diarrhoea or vomiting at the time of recruitment. 10. Subjects with severe infection, in perioperative period or with serious injury at the time of recruitment.\n\n  11\\. Subjects with anaemia (Haemoglobin \\\u003C9.0mg\u002FdL). 12. Pregnant or lactating or intending to become pregnant within 30 days after last dose of study drug.\n\n  13\\. Participation in a clinical trial with investigational product within 30 days before enrolment.\n\n  14\\. Donation or loss of blood (excluding the volume of blood that will be drawn during screening procedures) as follows: ≥300 mL of blood within 30 days prior to study drug administration.\n\n  15\\. Subjects judged unsuitable for the study based on investigator judgment. 16. Use of strong or moderate CYP3A4 inhibitors or inducers and cannot be discontinued.\n\n  17\\. Unwilling or unable to follow protocol requirements.","ALL","18 Years","70 Years",{"count":62,"type":63},30,"ESTIMATED","INTERVENTIONAL",[66],"NA","A total of 30 subjects will be recruited 15 with intermediate hyperglycemia and 15 in the tyep 2 diabetes group respectively. Eligible participants will undergo hyperglycemic-clamp\u002Foral glucose tolerance at baseline and after 4 weeks of dorzagliatin treatment.",[69,70],"Diabetes Mellitus","Prediabetes \u002F Type 2 Diabetes",[72,73,74],"clamp","diabetes","glucokinase activator","NOT_YET_RECRUITING","2025-03-01",{"date":78,"type":79},"2025-03-04","ACTUAL",{"date":81,"type":63},"2025-04-02",{"date":83,"type":63},"2026-01-31",{"name":27,"class":6},1]