[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100082288":3},{"organization":4,"armGroups":7,"interventions":10,"overallOfficials":21,"centralContacts":34,"locations":42,"responsibleParty":80,"collaborators":82,"id":90,"slug":91,"hasResults":92,"nctId":93,"briefTitle":94,"officialTitle":94,"acronym":95,"eligibilityCriteria":96,"healthyVolunteers":92,"sex":97,"minAge":98,"maxAge":99,"enrollmentInfo":100,"targetDuration":10,"studyType":103,"phases":10,"briefSummary":104,"conditions":105,"keywords":10,"overallStatus":44,"whyStopped":10,"lastUpdateSubmitDate":107,"lastUpdatePostDateStruct":108,"startDateStruct":111,"completionDateStruct":113,"leadSponsor":115,"locationsCount":116},{"fullName":5,"class":6},"Johns Hopkins Bloomberg School of Public Health","OTHER",[8,12,15,18],{"label":9,"type":10,"description":11,"interventionNames":10},"Cohort 1",null,"Age between 1 and 16 years (before 17th birthday) and estimated (based on SCr) Schwartz GFR between 30 and 90 ml\u002Fmin\\|1.73m2",{"label":13,"type":10,"description":14,"interventionNames":10},"Cohort 2","Age between 1 and 16 years (before 17th birthday), estimated GFR between 45 and 90 ml\u002Fmin\\|1.73m2 based on the updated Schwartz formula, and an equal distribution of children with glomerular and non-glomerular causes of disease were enrolled (i.e., 150 within each) and the study placed an upper limit of 60% for the percent of enrolled with non-glomerular disease.",{"label":16,"type":10,"description":17,"interventionNames":10},"Cohort 3","Age between 6 months and 16 years (before 17th birthday) with non-glomerular diagnosis and duration of kidney disease less than 5 years will be enrolled.",{"label":19,"type":10,"description":20,"interventionNames":10},"Cohort 4","Age between 16 and 22 years (before 23rd birthday) with moderately impaired kidney function as defined by estimated GFR less than 60 ml\u002Fmin\\|1.73m2 based on U25eGFR OR individuals who have initiated kidney replacement therapy (dialysis or transplant).",[22,26,29,31],{"name":23,"affiliation":24,"role":25},"Susan Furth, MD, PhD","Children's Hospital of Philadelphia","PRINCIPAL_INVESTIGATOR",{"name":27,"affiliation":28,"role":25},"Bradley Warady, MD","Children's Mercy Kansas City",{"name":30,"affiliation":5,"role":25},"Derek Ng, PhD",{"name":32,"affiliation":33,"role":25},"Jesse Seegmiller, PhD","University of Minnesota",[35,39],{"name":23,"role":36,"phone":37,"phoneExt":10,"email":38},"CONTACT","215-590-2449","FurthS@email.chop.edu",{"name":27,"role":36,"phone":40,"phoneExt":10,"email":41},"816-302-3010","bwarady@cmh.edu",[43,63],{"facility":28,"status":44,"city":45,"state":46,"zip":47,"country":48,"countryCode":49,"cosmosGeoPoint":50,"geoPoint":55,"contacts":56},"RECRUITING","Kansas City","Missouri","64108","United States","US",{"type":51,"coordinates":52},"Point",[53,54],-94.57857,39.09973,{"lat":54,"lon":53},[57,58,62],{"name":27,"role":36,"phone":40,"phoneExt":10,"email":41},{"name":59,"role":36,"phone":60,"phoneExt":10,"email":61},"Christine Smith, BSN, RN, CCRC","816-302-3278","casmith@cmh.edu",{"name":27,"role":25,"phone":10,"phoneExt":10,"email":10},{"facility":64,"status":44,"city":65,"state":66,"zip":67,"country":48,"countryCode":49,"cosmosGeoPoint":68,"geoPoint":72,"contacts":73},"The Children's Hospital of Philadelphia","Philadelphia","Pennsylvania","19146",{"type":51,"coordinates":69},[70,71],-75.16362,39.95238,{"lat":71,"lon":70},[74,75,79],{"name":23,"role":36,"phone":37,"phoneExt":10,"email":38},{"name":76,"role":36,"phone":77,"phoneExt":10,"email":78},"Hannah Derwick, MPH","267-425-1394","DERWICKH@chop.edu",{"name":23,"role":25,"phone":10,"phoneExt":10,"email":10},{"type":81,"investigatorFullName":10,"investigatorTitle":10,"investigatorAffiliation":10,"oldNameTitle":10,"oldOrganization":10},"SPONSOR",[83,86,88],{"name":84,"class":85},"National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)","NIH",{"name":87,"class":85},"Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)",{"name":89,"class":85},"National Heart, Lung, and Blood Institute (NHLBI)","100082288","chronic-kidney-disease-in-children-prospective-cohort-study-ckid-100082288",false,"NCT00327860","Chronic Kidney Disease in Children Prospective Cohort Study (CKiD)","CKiD","Inclusion Criteria:\n\n* Age between 1 and 16 years (before 17th birthday) for Cohorts 1 and 2; age between 6 months and 16 years (before 17th birthday) for Cohort 3; age between 16 to 22 years (before 23rd birthday) for Cohort 4\n* Estimated (based on SCr) Schwartz GFR between 30 and 90 ml\u002Fmin\\|1.73m2 for Cohort 1 OR an estimated GFR between 45 and 90 ml\u002Fmin\\|1.73m2 based on the updated Schwartz formula for Cohort 2; an estimated GFR ≤60 based on the CKiD Under 25 estimating equation (U25eGFR) OR KRT experience (dialysis or transplant) for Cohort 4\n* Willingness and ability to provide informed consent and assent\n* For Cohort 3, children with non-glomerular diagnosis and duration of kidney disease less than 5 years will be enrolled.\n\nExclusion Criteria:\n\n* Solid organ (other than kidney), bone marrow or stem cell transplantation\n* Cancer diagnosis and receiving treatment or within 12 months post completion of treatment\n* Ongoing monitoring for cardiotoxic effects of prior chemotherapy or targeted cancer therapies (e.g., anthracyclines, trastuzumab)\n* HIV infection with detectable viral load despite current antiretroviral therapy\n* Current pregnancy or pregnancy within past twelve months\n* Inability to complete major data collection procedures\n* Not fluent in English or Spanish\n* Plans to move out of area of any participating CKiD site (families can be transferred to another CKiD site if the family moves)\n* Existing moderate to severe congenital structural heart disease\n* Genetic syndromes involving the central nervous system (e.g., Downs syndrome)\n* History of severe to profound intellectual disability (i.e., Intelligence Quotient (IQ)\\\u003C40, significant impairment in adaptive function and\u002For inability to independently execute self-care skills)\n* For cohort 3, children who are expected to receive renal replacement therapy within 6 months of date of enrollment will not be recruited","ALL","6 Months","22 Years",{"count":101,"type":102},1300,"ESTIMATED","OBSERVATIONAL","The Division of Kidney, Urologic, and Hematologic Diseases (DKUHD) of the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), in collaboration with the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) and the National Heart, Lung and Blood Institute (NHLBI) funded a cooperative agreement including two Clinical Coordinating Centers (at Children's Hospital of Philadelphia and at Children's Mercy Hospital in Kansas City), a central biochemistry laboratory (at the University of Minnesota) and a Data Coordinating Center (at Johns Hopkins School of Public Health) to conduct a prospective epidemiological study of children with chronic kidney disease (CKD).",[106],"Chronic Kidney Disease","2026-04-14",{"date":109,"type":110},"2026-04-17","ACTUAL",{"date":112,"type":110},"2003-10",{"date":114,"type":102},"2028-07",{"name":5,"class":6},2]