[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100598718":3},{"organization":4,"armGroups":7,"interventions":25,"overallOfficials":43,"centralContacts":47,"locations":57,"responsibleParty":74,"collaborators":30,"id":76,"slug":77,"hasResults":78,"nctId":79,"briefTitle":80,"officialTitle":80,"acronym":81,"eligibilityCriteria":82,"healthyVolunteers":83,"sex":84,"minAge":85,"maxAge":86,"enrollmentInfo":87,"targetDuration":30,"studyType":90,"phases":91,"briefSummary":93,"conditions":94,"keywords":100,"overallStatus":107,"whyStopped":30,"lastUpdateSubmitDate":108,"lastUpdatePostDateStruct":109,"startDateStruct":112,"completionDateStruct":114,"leadSponsor":116,"locationsCount":117},{"fullName":5,"class":6},"University Hospital, Toulouse","OTHER",[8,15,20],{"label":9,"type":10,"description":11,"interventionNames":12},"Diet control (no chrono restriction) + exercise performed in the morning","EXPERIMENTAL","Patients following a standard antidiabetic diet combined with morning exercise",[13,14],"Other: Antidiabetic diet (control)","Other: Physical activity in the morning",{"label":16,"type":10,"description":17,"interventionNames":18},"eTRE (chrono restriction) + exercise performed in the morning","Patients following the eTRE program combined with physical exercise performed in the morning",[19,14],"Other: eTRE diet",{"label":21,"type":10,"description":22,"interventionNames":23},"eTRE (chrono restriction) + exercise performed in the afternoon","Patients following the eTRE program combined with physical exercise performed in the afternoon",[19,24],"Other: Physical activity in the afternoon",[26,31,35,39],{"type":6,"name":27,"description":28,"armGroupLabels":29,"otherNames":30},"Antidiabetic diet (control)","Standard antidiabetic diet",[9],null,{"type":6,"name":32,"description":33,"armGroupLabels":34,"otherNames":30},"eTRE diet","eTRE for a total duration of 12 weeks. During the eTRE, volunteers will have to eat and drink (meals + snacks, medication) exclusively during an 8-hour period which will extend between 6 a.m. (flexible: or 7 a.m. or 8 a.m.) in the morning and 2 p.m. (depending on the chosen start time: or 3 p.m. or 4 p.m.), which corresponds to a fasting period of 16 hours per day",[21,16],{"type":6,"name":36,"description":37,"armGroupLabels":38,"otherNames":30},"Physical activity in the morning","Physical exercise will consist of 3 weekly morning sessions that will combine aerobic and resistance exercises",[9,16],{"type":6,"name":40,"description":41,"armGroupLabels":42,"otherNames":30},"Physical activity in the afternoon","The physical exercise will consist of 3 weekly afternoon sessions that will combine aerobic and resistance exercises.",[21],[44],{"name":45,"affiliation":5,"role":46},"MONTASTIER Emilie, MD","PRINCIPAL_INVESTIGATOR",[48,53],{"name":45,"role":49,"phone":50,"phoneExt":51,"email":52},"CONTACT","5 61 32 30 41","+33","montastier.e@chu-toulouse.fr",{"name":54,"role":49,"phone":55,"phoneExt":51,"email":56},"TOMASIK Audrey","5 61 77 85 97","tomasik.a@chu-toulouse.fr",[58],{"facility":59,"status":30,"city":60,"state":61,"zip":62,"country":61,"countryCode":63,"cosmosGeoPoint":64,"geoPoint":69,"contacts":70},"Rangueil Hospital","Toulouse","France","31000","FR",{"type":65,"coordinates":66},"Point",[67,68],1.44367,43.60426,{"lat":68,"lon":67},[71,72,73],{"name":45,"role":49,"phone":50,"phoneExt":51,"email":52},{"name":54,"role":49,"phone":55,"phoneExt":51,"email":56},{"name":45,"role":46,"phone":30,"phoneExt":30,"email":30},{"type":75,"investigatorFullName":30,"investigatorTitle":30,"investigatorAffiliation":30,"oldNameTitle":30,"oldOrganization":30},"SPONSOR","100598718","chrono-restricted-diet-and-physical-activity-as-a-new-preventive-strategy-for-sarcopenia-in-postmenopausal-women-with-obesity-and-type-2-diabetes-100598718",false,"NCT07075133","Chrono-restricted Diet and Physical Activity as a New Preventive Strategy for Sarcopenia in Postmenopausal Women With Obesity and Type 2 Diabetes","TIMEDIAB","Inclusion Criteria:\n\n* Post-menopausal women (amenorrhea for at least 12 months, confirmed by gonadotrophins measures)\n* Age range 45-70 years\n* T2DM diagnosed for more than 1 year\n* Subjects with T2DM treated with lifestyle control alone or associated with metformine ± DPP4 inhibitors\n* Ability to sign written informed consent before any study-specific procedure\n* Subject considered as reliable and capable of adhering to protocol\n* Subjects with Body Mass Index (BMI)≥ 30 kg\u002Fm²\n* Baseline eating period ≥ 14 h per day (as estimated by 95% eating interval)\n\nExclusion Criteria:\n\n* Subjects on T2DM injectable medication or drugs able to induce hypoglycemia (glinides, sulfonylurea)\n* Subjects with HbA1c \\> 8%\n* Subjects with any of the following medical conditions:\n\n  * Congestive cardiac failure\n  * Stage 4 chronic kidney disease (i.e. eGFR \\\u003C 30 ml\u002Fmin\u002F1.73 m2)\n  * Liver cirrhosis or chronic liver disease\n  * Any medical condition that in the opinion of the investigator could jeopardize or compromise the subject's ability to participate in the study\n* Subjects with previous or present history of serious eating disorder\n* Subjects not able to understand the informed consent form or fasting diary instructions\n* Subjects currently participating or has participated in another study of an investigational medication or an investigational medical device within the last 30 days\n* Women with menopause hormone replacement therapy",true,"ALL","45 Years","70 Years",{"count":88,"type":89},45,"ESTIMATED","INTERVENTIONAL",[92],"NA","The aim of TIMEDIAB is to demonstrate that early TRE (eTRE) combined to late (afternoon) exercise will outperform eTRE combined to morning exercise on muscle function as primary endpoint, and glucose homeostasis as secondary endpoint",[95,96,97,98,99],"Obesity","Sarcopenia","Post Menopause","Type 2 Diabetes","Circadian Clock",[101,102,103,104,95,105,106],"Timing of eating","Timing of exercise","Muscle Function","Metabolic Health","Menopause","women","NOT_YET_RECRUITING","2026-05-28",{"date":110,"type":111},"2026-06-01","ACTUAL",{"date":113,"type":89},"2026-09-15",{"date":115,"type":89},"2029-07-15",{"name":5,"class":6},1]