[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100640692":3},{"organization":4,"armGroups":7,"interventions":24,"overallOfficials":29,"centralContacts":33,"locations":43,"responsibleParty":55,"collaborators":59,"id":66,"slug":67,"hasResults":68,"nctId":69,"briefTitle":70,"officialTitle":71,"acronym":72,"eligibilityCriteria":73,"healthyVolunteers":74,"sex":75,"minAge":76,"maxAge":77,"enrollmentInfo":78,"targetDuration":10,"studyType":81,"phases":10,"briefSummary":82,"conditions":83,"keywords":88,"overallStatus":98,"whyStopped":10,"lastUpdateSubmitDate":99,"lastUpdatePostDateStruct":100,"startDateStruct":103,"completionDateStruct":105,"leadSponsor":107,"locationsCount":108},{"fullName":5,"class":6},"Inonu University","OTHER",[8,12,17,20],{"label":9,"type":10,"description":11,"interventionNames":10},"Normal Circadian \u002F Periodontally Healthy",null,"Individuals with normal circadian rhythm and periodontal health (control group). Inclusion: PD \\\u003C=3 mm, BOP \\\u003C10%, CAL=0, no radiographic bone loss. n=29",{"label":13,"type":10,"description":14,"interventionNames":15},"Normal Circadian \u002F Gingivitis","Individuals with normal circadian rhythm and gingivitis. Inclusion: PD \\\u003C=3 mm, 10%\\\u003C=BOP\\\u003C=30%, CAL=0, no radiographic bone loss. These participants will receive standard periodontal treatment and be re-evaluated at 14 days post-treatment. n=29",[16],"Other: Standard Periodontal Treatment",{"label":18,"type":10,"description":19,"interventionNames":10},"Disrupted Circadian \u002F Periodontally Healthy","Night-shift workers with circadian rhythm disruption and periodontal health. Circadian rhythm status verified by MEQ and MCTQ questionnaires. Inclusion: PD \\\u003C=3 mm, BOP \\\u003C10%, CAL=0, no radiographic bone loss. n=29",{"label":21,"type":10,"description":22,"interventionNames":23},"Disrupted Circadian \u002F Gingivitis","Night-shift workers with circadian rhythm disruption and gingivitis. Circadian rhythm status verified by MEQ and MCTQ questionnaires. Inclusion: PD \\\u003C=3 mm, 10%\\\u003C=BOP\\\u003C=30%, CAL=0, no radiographic bone loss. These participants will receive standard periodontal treatment and be re-evaluated at 14 days post-treatment. n=29",[16],[25],{"type":6,"name":26,"description":27,"armGroupLabels":28,"otherNames":10},"Standard Periodontal Treatment","Standard periodontal treatment including detailed oral hygiene instruction and professional dental surface cleaning (scaling and polishing). Applied to gingivitis groups (Group 2 and Group 4) at baseline, with clinical and biochemical re-evaluation at 14 days post-treatment.",[21,13],[30],{"name":31,"affiliation":5,"role":32},"Cuneyt A Aral, Professor, DDS, PhD","STUDY_CHAIR",[34,39],{"name":35,"role":36,"phone":37,"phoneExt":10,"email":38},"Cüneyt A Aral, Chair, Professor Dr, DDS, PhD","CONTACT","+905424577657","cuneytasimaral@gmail.com",{"name":40,"role":36,"phone":41,"phoneExt":10,"email":42},"Kübra Aral, Assoc. Professor, DDS, PhD","+905330578801","drkubraaral@gmail.com",[44],{"facility":45,"status":10,"city":46,"state":46,"zip":47,"country":48,"countryCode":10,"cosmosGeoPoint":49,"geoPoint":54,"contacts":10},"Inönü University Faculty of Dentistry, Department of Periodontology","Malatya","44210","Turkey (Türkiye)",{"type":50,"coordinates":51},"Point",[52,53],38.31667,38.35018,{"lat":53,"lon":52},{"type":56,"investigatorFullName":57,"investigatorTitle":58,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"PRINCIPAL_INVESTIGATOR","Cuneyt Asim Aral","Professor of Periodontology, Inonu University Faculty of Dentistry",[60,62,64],{"name":61,"class":6},"University of Minnesota",{"name":63,"class":6},"Harvard University",{"name":65,"class":6},"University of Turku","100640692","circadian-clock-proteins-in-gingival-crevicular-fluid-of-individuals-with-and-without-circadian-rhythm-disruption-100640692",false,"NCT07592052","Circadian Clock Proteins in Gingival Crevicular Fluid of Individuals With and Without Circadian Rhythm Disruption","Investigation of Circadian Clock Gene\u002FProteins in Individuals With and Without Disrupted Circadian Rhythm: A Prospective Cross-Sectional Clinical Study","Nursma-CIRC-HG","Inclusion Criteria:\n\n* Aged between 20 and 50 years\n* Systemically healthy\n* Diagnosed as periodontally healthy or with gingivitis based on clinical periodontal examination\n* Having at least 20 natural teeth in the oral cavity\n* Willing to provide written informed consent\n* Agreeing to participate in circadian rhythm assessment and completing the Morningness-Eveningness Questionnaire (MEQ) and Munich Chronotype Questionnaire (MCTQ)\n* Sleep duration of 6-9 hours per day\n* For periodontally healthy: PD \\\u003C=3 mm, BOP \\\u003C10%, CAL=0, no radiographic bone loss\n* For gingivitis: PD \\\u003C=3 mm, 10%\\\u003C=BOP\\\u003C=30%, CAL=0, no radiographic bone loss\n* For circadian rhythm disruption group: being a night-shift worker\n\nExclusion Criteria:\n\n* Use of antioxidant or melatonin supplements\n* Presence of any systemic disease\n* Use of antibiotics, anti-inflammatory drugs, or immunosuppressants within the past 3 months\n* Having received periodontal treatment within the past 6 months\n* Pregnancy or lactation\n* Use of tobacco or tobacco products\n* Presence of acute oral infection, abscess, or advanced periodontal disease\n* Currently undergoing orthodontic treatment or having fixed orthodontic appliances\n* Inability to comply with study procedures or refusal to provide informed consent\n* Self-reported sleep duration less than 6 hours or greater than 9 hours per day",true,"ALL","20 Years","50 Years",{"count":79,"type":80},116,"ESTIMATED","OBSERVATIONAL","This prospective cross-sectional clinical study aims to investigate the relationship between circadian rhythm disruption and periodontal inflammation by evaluating circadian clock protein levels, inflammatory (IL-1beta) and anti-inflammatory (IL-10) cytokine levels in gingival crevicular fluid (GCF) of individuals with and without circadian rhythm disruption.\n\nParticipants aged 20-50 years will be classified into four groups based on their circadian rhythm status (disrupted\u002Fnormal) and gingival health status (gingivitis\u002Fhealthy). Clinical periodontal parameters including plaque index, gingival index, bleeding on probing, and probing depth will be assessed. Circadian rhythm status will be determined using validated questionnaires (Morningness-Eveningness Questionnaire and Munich Chronotype Questionnaire). Night-shift workers will represent the circadian rhythm disruption group.\n\nGCF samples will be analyzed for circadian clock proteins (BMAL-1, CLOCK, PER-1, PER-2, PER-3, CRY-1, CRY-2, REV-ERB-beta, MTNR1B) and cytokines (IL-1beta, IL-10) using ELISA. Serum cortisol and melatonin levels will be measured for biochemical verification of circadian rhythm status.\n\nGingivitis groups will receive standard periodontal treatment and be re-evaluated at 2 weeks post-treatment. A total of 116 participants (29 per group) are planned for enrollment.",[84,85,86,87],"Gingivitis","Circadian Rhythm Disruption","Periodontal Inflammation","Circadian Rhythm Sleep Disorder, Shift Work Type",[89,90,84,91,92,93,94,95,96,97],"Circadian rhythm","Periodontal health","Gingival crevicular fluid","Clock genes","BMAL1","Night shift work","IL-1beta","IL-10","Chronotype","NOT_YET_RECRUITING","2026-05-11",{"date":101,"type":102},"2026-05-18","ACTUAL",{"date":104,"type":80},"2026-08-01",{"date":106,"type":80},"2027-03-01",{"name":5,"class":6},1]