[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100504902":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":30,"centralContacts":35,"locations":44,"responsibleParty":126,"collaborators":128,"id":131,"slug":132,"hasResults":133,"nctId":134,"briefTitle":135,"officialTitle":135,"acronym":136,"eligibilityCriteria":137,"healthyVolunteers":138,"sex":139,"minAge":140,"maxAge":25,"enrollmentInfo":141,"targetDuration":25,"studyType":144,"phases":145,"briefSummary":147,"conditions":148,"keywords":152,"overallStatus":58,"whyStopped":25,"lastUpdateSubmitDate":154,"lastUpdatePostDateStruct":155,"startDateStruct":158,"completionDateStruct":160,"leadSponsor":162,"locationsCount":163},{"fullName":5,"class":6},"Institut Pasteur","INDUSTRY",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Patients with gastric lesion","OTHER","Patients with:\n\n* Gastric epithelial dysplasia\n* Glandular atrophy of the gastric mucosa\n* Intestinal metaplasia of the gastric mucosa\n* Proximal gastric adenocarcinoma\n* Distal gastric adenocarcinoma",[13],"Procedure: Additional blood collection as part of a blood sampling performed during routine care or specific for the research if not part of routine care.",{"label":15,"type":10,"description":16,"interventionNames":17},"Control","Healthy Volunteers",[18],"Procedure: Blood collection",[20,26],{"type":21,"name":22,"description":23,"armGroupLabels":24,"otherNames":25},"PROCEDURE","Additional blood collection as part of a blood sampling performed during routine care or specific for the research if not part of routine care.","Collection of an additional blood volume (9 mL) as part of a blood sampling performed during routine care or specific for the research if not part of routine care.",[9],null,{"type":21,"name":27,"description":28,"armGroupLabels":29,"otherNames":25},"Blood collection","Blood sample collection (10 mL)",[15],[31],{"name":32,"affiliation":33,"role":34},"Dominique LAMARQUE, MD, PhD","Ambroise Paré Teaching Hospital (AP-HP)","PRINCIPAL_INVESTIGATOR",[36,41],{"name":37,"role":38,"phone":39,"phoneExt":25,"email":40},"Eliette TOUATI, PhD","CONTACT","+33140613785","eliette.touati@pasteur.fr",{"name":42,"role":38,"phone":25,"phoneExt":25,"email":43},"Olivia CHENY, PhD","olivia.cheny@pasteur.fr",[45,56,68,79,90,98,106,116],{"facility":33,"status":46,"city":47,"state":25,"zip":25,"country":48,"countryCode":49,"cosmosGeoPoint":50,"geoPoint":55,"contacts":25},"COMPLETED","Boulogne-Billancourt","France","FR",{"type":51,"coordinates":52},"Point",[53,54],2.24128,48.83545,{"lat":54,"lon":53},{"facility":57,"status":58,"city":59,"state":25,"zip":25,"country":48,"countryCode":49,"cosmosGeoPoint":60,"geoPoint":64,"contacts":65},"Beaujon Teaching Hospital (AP-HP)","RECRUITING","Clichy",{"type":51,"coordinates":61},[62,63],2.30952,48.90018,{"lat":63,"lon":62},[66],{"name":67,"role":38,"phone":25,"phoneExt":25,"email":25},"Frédéric PRAT, MD, PhD",{"facility":69,"status":58,"city":70,"state":25,"zip":25,"country":48,"countryCode":49,"cosmosGeoPoint":71,"geoPoint":75,"contacts":76},"Kremlin Bicêtre Teaching Hospital (AP-HP)","Le Kremlin-Bicêtre",{"type":51,"coordinates":72},[73,74],2.36073,48.81471,{"lat":74,"lon":73},[77],{"name":78,"role":38,"phone":25,"phoneExt":25,"email":25},"Aurélien AMIOT, MD, PhD",{"facility":80,"status":58,"city":81,"state":25,"zip":25,"country":48,"countryCode":49,"cosmosGeoPoint":82,"geoPoint":86,"contacts":87},"Cochin Teaching Hospital (AP-HP)","Paris",{"type":51,"coordinates":83},[84,85],2.3488,48.85341,{"lat":85,"lon":84},[88],{"name":89,"role":38,"phone":25,"phoneExt":25,"email":25},"Romain CORIAT, MD, PhD",{"facility":91,"status":58,"city":81,"state":25,"zip":25,"country":48,"countryCode":49,"cosmosGeoPoint":92,"geoPoint":94,"contacts":95},"INVOLvE - Investigation et volontaires en santé humaine (Institut Pasteur)",{"type":51,"coordinates":93},[84,85],{"lat":85,"lon":84},[96],{"name":97,"role":38,"phone":25,"phoneExt":25,"email":25},"Hélène LAUDE, MD",{"facility":99,"status":58,"city":81,"state":25,"zip":25,"country":48,"countryCode":49,"cosmosGeoPoint":100,"geoPoint":102,"contacts":103},"Saint Antoine Teaching Hospital (AP-HP)",{"type":51,"coordinates":101},[84,85],{"lat":85,"lon":84},[104],{"name":105,"role":38,"phone":25,"phoneExt":25,"email":25},"Xavier DRAY, MD, PhD",{"facility":99,"status":107,"city":81,"state":25,"zip":25,"country":48,"countryCode":49,"cosmosGeoPoint":108,"geoPoint":110,"contacts":111},"NOT_YET_RECRUITING",{"type":51,"coordinates":109},[84,85],{"lat":85,"lon":84},[112],{"name":113,"role":38,"phone":114,"phoneExt":25,"email":115},"Thibault VORON, MD, MCU-PH","+33 1 49 28 25 47","thibault.voron@aphp.fr",{"facility":117,"status":107,"city":81,"state":25,"zip":25,"country":48,"countryCode":49,"cosmosGeoPoint":118,"geoPoint":120,"contacts":121},"Saint Louis Teaching Hospital (AP-HP)",{"type":51,"coordinates":119},[84,85],{"lat":85,"lon":84},[122],{"name":123,"role":38,"phone":124,"phoneExt":25,"email":125},"Pierre CATTAN, Pr","+33 1 42 49 93 81","pierre.cattan@aphp.fr",{"type":127,"investigatorFullName":25,"investigatorTitle":25,"investigatorAffiliation":25,"oldNameTitle":25,"oldOrganization":25},"SPONSOR",[129],{"name":130,"class":10},"Assistance Publique - Hôpitaux de Paris","100504902","circulating-biomarker-signatures-for-the-detection-of-gastric-preneoplasia-and-cancer-100504902",false,"NCT05854368","Circulating Biomarker Signatures for the Detection of Gastric Preneoplasia and Cancer","PREGASIGN#1","Inclusion Criteria:\n\nCommon\n\n* 18 years old or highter\n* written informed consent prior to any study procedure\n* Affiliated to a social insurance system\n\nSpecific to patients with gastric lesions\n\n* Untreated glandular atrophy (with or without intestinal metaplasia and\u002For dysplasia) and histologically diagnosed as of 2014\n* Treatment naïve Gastric cancer (distal or proximal adenocarcinoma)\n\nExclusion Criteria:\n\nCommon\n\n* Autoimmune disease or disease that impacts the immune system (e.g: HIV)\n* Chronic inflammatory disease\n* Known evolutive cancer (excluding gastric cancer)\n* Treated in the last 3 months or currently treated with therapy that interferes with the immune system (e.g. immunosuppressive therapy)\n* Current treatment with long-term corticosteroid therapy\n* Current treatment with long-term nonsteroidal anti-inflammatory drugs\n* Pregnant woman or breastfeeding\n* Patient or healthy volunteer under legal protection (e.g. guardianship)\n* Patient or healthy volunteer currently participating to a clinical trial evaluating either an experimental medical product or a medical device\n* Patient or healthy volunteer currently in custody\n\nSpecific to Healthy Volunteer\n\n* Known history of Helicobacter pylori infection\n* Known history of gastric lesions (i.e. chronic gastritis, gastric atrophy, intestinal metaplasia, dysplasia and cancer)",true,"ALL","18 Years",{"count":142,"type":143},2500,"ESTIMATED","INTERVENTIONAL",[146],"NA","The goal of this study is to characterize and validate a signature of circulating biomarkers in plasma, associated with the presence of gastric preneoplasia in patients with preexisting gastric lesion compared with a control group.\n\nFor this purpose:\n\n* Patients with pre-existing gastric lesions will be invited to participate to this study. If they are willing to participate an additional blood sample (9 mL) will be collected at the time of the blood collection performed during their routine care\n* Healthy subjects will be invited to participate to constitute the control group. If they are willing to participate a blood sample (9 ml) will be drawn specifically for this study",[149,150,151],"Gastric Lesion","Gastric Precancerous Condition","Gastric Cancer",[153],"Gastric Cancer, biomarkers,","2025-05-13",{"date":156,"type":157},"2025-05-16","ACTUAL",{"date":159,"type":157},"2023-07-03",{"date":161,"type":143},"2025-12",{"name":5,"class":6},8]