[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100375990":3},{"organization":4,"armGroups":7,"interventions":18,"overallOfficials":26,"centralContacts":31,"locations":40,"responsibleParty":58,"collaborators":10,"id":60,"slug":61,"hasResults":62,"nctId":63,"briefTitle":64,"officialTitle":65,"acronym":66,"eligibilityCriteria":67,"healthyVolunteers":68,"sex":69,"minAge":70,"maxAge":10,"enrollmentInfo":71,"targetDuration":74,"studyType":75,"phases":10,"briefSummary":76,"conditions":77,"keywords":80,"overallStatus":42,"whyStopped":10,"lastUpdateSubmitDate":85,"lastUpdatePostDateStruct":86,"startDateStruct":89,"completionDateStruct":91,"leadSponsor":93,"locationsCount":94},{"fullName":5,"class":6},"Nanjing First Hospital, Nanjing Medical University","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"AIS group",null,"This group includes patients with acute ischemic stroke (AIS).",[13],"Genetic: Sequencing of circRNA\u002FmiRNA\u002FlncRNA",{"label":15,"type":10,"description":16,"interventionNames":17},"HC group","This group includes healthy controls (HC).",[13],[19],{"type":20,"name":21,"description":22,"armGroupLabels":23,"otherNames":24},"GENETIC","Sequencing of circRNA\u002FmiRNA\u002FlncRNA","Next generation sequencing of circular RNA (circRNA), micro-RNA (miRNA) and long non-coding RNA (lncRNA)",[9,15],[25],"Quantitative Real-time polymerase chain reaction",[27],{"name":28,"affiliation":29,"role":30},"Junshan Zhou, Professor","Nanjing Medical University","STUDY_CHAIR",[32,37],{"name":33,"role":34,"phone":35,"phoneExt":10,"email":36},"Junshan Zhou, M.D.","CONTACT","+8602587726218","zhjsh333@126.com",{"name":38,"role":34,"phone":35,"phoneExt":10,"email":39},"Qiwen Deng, M.D.","qiw_deng@163.com",[41],{"facility":5,"status":42,"city":43,"state":44,"zip":45,"country":46,"countryCode":47,"cosmosGeoPoint":48,"geoPoint":53,"contacts":54},"RECRUITING","Nanjing","Jiangsu","210006","China","CN",{"type":49,"coordinates":50},"Point",[51,52],118.77778,32.06167,{"lat":52,"lon":51},[55,57],{"name":33,"role":34,"phone":56,"phoneExt":10,"email":36},"+86025-87726218",{"name":38,"role":34,"phone":56,"phoneExt":10,"email":39},{"type":59,"investigatorFullName":10,"investigatorTitle":10,"investigatorAffiliation":10,"oldNameTitle":10,"oldOrganization":10},"SPONSOR","100375990","circulating-non-coding-rna-in-acute-ischemic-stroke-aisrna-100375990",false,"NCT04175691","Circulating Non-coding RNA in Acute Ischemic Stroke (AISRNA)","Clinical Significance of Circulating Non-coding RNA in Acute Ischemic Stroke (AISRNA)","AISRNA","Inclusion Criteria:\n\n* Aged 18 years or older\n* Confirmed acute ischemic stroke by a diffusion-weighted imaging-position lesion on magnetic resonance imaging (MRI) and a new lesion on a brain computed tomography (CT) scan\n* Within 72 hours of symptom onset\n* Good performance status\n* Signed an approved informed consents\n\nExclusion Criteria:\n\n-a history of hemorrhagic infarction, chronic kidney\u002Fliver diseases, peripheral arterial occlusive disease, active malignant disease, and inflammatory or infectious diseases",true,"ALL","18 Years",{"count":72,"type":73},500,"ESTIMATED","90 Days","OBSERVATIONAL","AISRNA is to analyze the expression pattern of circular RNA (circRNA), micro-RNA (miRNA) and long non-coding RNA (lncRNA) by next-generation sequencing in patients with acute ischemic stroke and healthy control. The candidate circRNA\u002FmiRNA\u002FlncRNA will be verified as biomarkers for the detection and prognosis of acute ischemic stroke.",[78,79],"Acute Stroke","Ischemic Stroke",[81,82,83,84],"acute ischemic stroke","noncoding RNA","clinical significance","outcome","2026-04-10",{"date":87,"type":88},"2026-04-15","ACTUAL",{"date":90,"type":88},"2019-11-24",{"date":92,"type":73},"2026-12-31",{"name":5,"class":6},1]