[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100645379":3},{"organization":4,"armGroups":7,"interventions":16,"overallOfficials":22,"centralContacts":23,"locations":29,"responsibleParty":106,"collaborators":22,"id":108,"slug":109,"hasResults":110,"nctId":111,"briefTitle":112,"officialTitle":112,"acronym":22,"eligibilityCriteria":113,"healthyVolunteers":114,"sex":115,"minAge":116,"maxAge":22,"enrollmentInfo":117,"targetDuration":22,"studyType":120,"phases":121,"briefSummary":123,"conditions":124,"keywords":22,"overallStatus":32,"whyStopped":22,"lastUpdateSubmitDate":135,"lastUpdatePostDateStruct":136,"startDateStruct":139,"completionDateStruct":141,"leadSponsor":143,"locationsCount":144},{"fullName":5,"class":6},"Carl Zeiss Meditec-Dublin CoCe","INDUSTRY",[8,13],{"label":9,"type":10,"description":9,"interventionNames":11},"Subjects with absence of macular abnormalities","OTHER",[12],"Device: PathFinder 1.0 on CIRRUS HD-OCT",{"label":14,"type":10,"description":14,"interventionNames":15},"Subjects with presence of macular abnormalities",[12],[17],{"type":18,"name":19,"description":20,"armGroupLabels":21,"otherNames":22},"DEVICE","PathFinder 1.0 on CIRRUS HD-OCT","Participants undergo standard OCT imaging on CIRRUS HD-OCT systems, and the investigational PathFinder software analyzes the images for macular abnormalities without influencing clinical care.",[9,14],null,[24],{"name":25,"role":26,"phone":27,"phoneExt":22,"email":28},"Patricia Sha, Optometrist","CONTACT","925-307-1588","patricia.sha@zeiss.com",[30,47,59,69,81,94],{"facility":31,"status":32,"city":33,"state":34,"zip":35,"country":36,"countryCode":37,"cosmosGeoPoint":38,"geoPoint":43,"contacts":44},"Retina Associates","RECRUITING","Tucson","Arizona","85704","United States","US",{"type":39,"coordinates":40},"Point",[41,42],-110.92648,32.22174,{"lat":42,"lon":41},[45],{"name":46,"role":26,"phone":22,"phoneExt":22,"email":22},"Study Coordinator",{"facility":48,"status":32,"city":49,"state":50,"zip":51,"country":36,"countryCode":37,"cosmosGeoPoint":52,"geoPoint":56,"contacts":57},"Northern California Retina Vitreous Associates","Mountain View","California","94040",{"type":39,"coordinates":53},[54,55],-122.08385,37.38605,{"lat":55,"lon":54},[58],{"name":46,"role":26,"phone":22,"phoneExt":22,"email":22},{"facility":60,"status":61,"city":62,"state":50,"zip":63,"country":36,"countryCode":37,"cosmosGeoPoint":64,"geoPoint":68,"contacts":22},"Premier Eyecare of San Francisco","COMPLETED","San Francisco","94110",{"type":39,"coordinates":65},[66,67],-122.41942,37.77493,{"lat":67,"lon":66},{"facility":70,"status":32,"city":71,"state":72,"zip":73,"country":36,"countryCode":37,"cosmosGeoPoint":74,"geoPoint":78,"contacts":79},"Nova Southeastern University College of Optometry","Fort Lauderdale","Florida","33328",{"type":39,"coordinates":75},[76,77],-80.14338,26.12231,{"lat":77,"lon":76},[80],{"name":46,"role":26,"phone":22,"phoneExt":22,"email":22},{"facility":82,"status":32,"city":83,"state":84,"zip":85,"country":36,"countryCode":37,"cosmosGeoPoint":86,"geoPoint":90,"contacts":91},"Eyecare Medical Group","Portland","Maine","04102",{"type":39,"coordinates":87},[88,89],-70.2589,43.65737,{"lat":89,"lon":88},[92],{"name":93,"role":26,"phone":22,"phoneExt":22,"email":22},"study coordinator",{"facility":95,"status":32,"city":96,"state":97,"zip":98,"country":36,"countryCode":37,"cosmosGeoPoint":99,"geoPoint":103,"contacts":104},"Moyes Eye Center","Kansas City","Missouri","64154",{"type":39,"coordinates":100},[101,102],-94.57857,39.09973,{"lat":102,"lon":101},[105],{"name":46,"role":26,"phone":22,"phoneExt":22,"email":22},{"type":107,"investigatorFullName":22,"investigatorTitle":22,"investigatorAffiliation":22,"oldNameTitle":22,"oldOrganization":22},"SPONSOR","100645379","cirrus-2023-1-clinical-clin-assessment-of-pathfinder-10-on-the-cirrus-6000-and-the-cirrus-5000-100645379",false,"NCT07680244","(CIRRUS-2023-1) CLINICAL CLIN Assessment of PathFinder 1.0 on the CIRRUS 6000 and the CIRRUS 5000","Inclusion Criteria:\n\n1. Able and willing to make the required study visits.\n2. Able and willing to give written informed consent and follow study instructions.\n3. Able and willing to complete ophthalmic imaging.\n4. Adults 18 years of age or older.\n\nThe subject population will be comprised of two groups (all categories below pertain to the central 6x6 mm macula area):\n\nGroup A\n\n1\\. Subjects with absence of macular abnormalities Group B\n\n1. Subjects with Disruption of the vitreoretinal interface (VRI)\n2. Subjects with Intraretinal hyporeflective space (IRHS)\n3. Subjects with Subretinal hyporeflective space (SRHS)\n4. Subjects with IS\u002FOS (Ellipsoid Zone) disruption\n5. Subjects with Retinal Pigment Epithelium (RPE) elevation\n6. Subjects with Retinal Pigment Epithelium (RPE) atrophy\n7. Other abnormalities\n\nExclusion Criteria:\n\n1. Inability to undergo the required tests.\n2. Unable to give consent or follow study instructions.\n3. Inability to fixate that precludes obtaining acceptable macula scans in the study eye.\n4. Visudyne (verteporfin) injection within the last 48 hours in the study eye.\n5. Pilocarpine or Vuity use within the last 24 hours in the study eye.\n6. Dense media opacity precluding adequate visualization of the retina in the study eye.\n7. Vitreous floaters that preclude obtaining acceptable scans in the study eye.",true,"ALL","18 Years",{"count":118,"type":119},400,"ESTIMATED","INTERVENTIONAL",[122],"NA","This study will measure how well PathFinder 1.0 detects retinal abnormalities on macular cube OCT B-scans by assessing its sensitivity and specificity.",[125,126,127,128,129,130,131,132,133,134],"Epiretinal Membrane","Dry Age Related Macular Degeneration","Macular Abnormalities","Retina Disease","Vitreoretinal Abnormality","Intraretinal Hyporeflective Space","Subretinal Hyporeflective Space","IS\u002FOS (Ellipsoid Zone) Disruption","Retinal Pigment Epithelium (RPE) Elevation","Retinal Pigment Epithelium (RPE) Atrophy","2026-06-29",{"date":137,"type":138},"2026-07-02","ACTUAL",{"date":140,"type":138},"2025-05-23",{"date":142,"type":119},"2026-08",{"name":5,"class":6},6]