[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100584291":3},{"organization":4,"armGroups":7,"interventions":15,"overallOfficials":10,"centralContacts":10,"locations":21,"responsibleParty":42,"collaborators":10,"id":44,"slug":45,"hasResults":46,"nctId":47,"briefTitle":48,"officialTitle":49,"acronym":50,"eligibilityCriteria":51,"healthyVolunteers":46,"sex":52,"minAge":53,"maxAge":10,"enrollmentInfo":54,"targetDuration":10,"studyType":57,"phases":10,"briefSummary":58,"conditions":59,"keywords":10,"overallStatus":63,"whyStopped":10,"lastUpdateSubmitDate":64,"lastUpdatePostDateStruct":65,"startDateStruct":68,"completionDateStruct":70,"leadSponsor":72,"locationsCount":73},{"fullName":5,"class":6},"University Hospital, Strasbourg, France","OTHER",[8,13],{"label":9,"type":10,"description":10,"interventionNames":11},"Cladribine group",null,[12],"Drug: Cladribine",{"label":14,"type":10,"description":10,"interventionNames":10},"Continuing treatment group",[16],{"type":17,"name":18,"description":19,"armGroupLabels":20,"otherNames":10},"DRUG","Cladribine","To evaluate the clinical activity during the 2 years of follow-up in patients switching to cladribine and continuing current DMT",[9],[22],{"facility":23,"status":10,"city":24,"state":10,"zip":25,"country":26,"countryCode":27,"cosmosGeoPoint":28,"geoPoint":33,"contacts":34},"Service de neurologie - Hôpitaux Universitaires de Strasbourg","Strasbourg","67000","France","FR",{"type":29,"coordinates":30},"Point",[31,32],7.74553,48.58392,{"lat":32,"lon":31},[35,39],{"name":36,"role":37,"phone":38,"phoneExt":10,"email":10},"Jérôme DE SEZE","CONTACT","+ 33 3 88 12 85 43",{"name":40,"role":41,"phone":10,"phoneExt":10,"email":10},"Kévin BIGAUT","PRINCIPAL_INVESTIGATOR",{"type":43,"investigatorFullName":10,"investigatorTitle":10,"investigatorAffiliation":10,"oldNameTitle":10,"oldOrganization":10},"SPONSOR","100584291","cladribine-tablets-as-an-exit-therapy-strategy-100584291",false,"NCT06887426","Cladribine Tablets as an Exit Therapy Strategy","Cladribine Tablets as an Exit Therapy Strategy: Alternative to Continuing Treatment and Plain Treatment Discontinuation in Ageing Stable RMS Patients","CLADREXIT","Inclusion Criteria:\n\n* Patient ≥45-year-old with RRMS\n* Disease duration ≥10 years\n* No evidence of disease activity ≥5 years under DMT\n* EDSS score between 0 and 6.0 included\n\nExclusion Criteria:\n\n* Progressive form of MS\n* Patients without DMT\n* EDSS score ≥6.5","ALL","45 Years",{"count":55,"type":56},450,"ESTIMATED","OBSERVATIONAL","The objective of the study is to evaluate the effectiveness of CladT, in terms of disease stability and safety, as the last treatment option in ageing MS patients vs treatment continuation and discontinuation This observational study will use database from local cohorts (from France, Belgium, Switzerland). Patients included must meet the inclusion criteria: RRMS diagnosis for more than 10 years without secondary progression, no evidence of disease activity (no relapse, no new MRI lesion, no EDSS progression) for more than 5 years under a DMT, age≥ 45-year-old.\n\nAnalyses will be using dynamic propensity score to match patients who stopped treatment with patients who had the same probability of continuing \u002F stopping current treatments but took CladT as exit therapy. Patients with a minimum of 24 months follow up will be included.\n\nThe investigators will ensure that CladT provide disease stability compared to treatment continuation \u002F discontinuation in ageing MS patients by measuring:\n\n* the percentage of patients free of relapse, and time to first relapse, defined as the appearance, recurrence, or aggravation of neurological symptoms for a period of at least 24 hours without fever.\n* the percentage of patients free of EDSS progression confirmed for at least 6 months and until the end of patient follow up.\n* the percentage of patients free of MRI activity, defined as new or enlarged T2 lesions compared with the previous brain MRI scan or gadolinium enhancing T1 lesions.",[60,61,62],"Multiple Sclerosis","Relapsing Remitting Multiple Sclerosis","Secondary Progressive Multiple Sclerosis","NOT_YET_RECRUITING","2025-05-27",{"date":66,"type":67},"2025-06-02","ACTUAL",{"date":69,"type":56},"2025-06",{"date":71,"type":56},"2025-12",{"name":5,"class":6},1]