[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100461174":3},{"organization":4,"armGroups":7,"interventions":22,"overallOfficials":27,"centralContacts":31,"locations":40,"responsibleParty":60,"collaborators":62,"id":67,"slug":68,"hasResults":69,"nctId":70,"briefTitle":71,"officialTitle":72,"acronym":73,"eligibilityCriteria":74,"healthyVolunteers":75,"sex":76,"minAge":77,"maxAge":21,"enrollmentInfo":78,"targetDuration":21,"studyType":81,"phases":82,"briefSummary":84,"conditions":85,"keywords":21,"overallStatus":43,"whyStopped":21,"lastUpdateSubmitDate":88,"lastUpdatePostDateStruct":89,"startDateStruct":92,"completionDateStruct":94,"leadSponsor":96,"locationsCount":97},{"fullName":5,"class":6},"Johns Hopkins University","OTHER",[8,14,18],{"label":9,"type":10,"description":11,"interventionNames":12},"Hotspot-focused ACF\u002FTPT","EXPERIMENTAL","ACF\u002FTPT intervention will be delivered in a community setting, in geographic areas judged likely to have a high burden of undiagnosed TB",[13],"Other: Active TB case finding with linkage to preventive therapy (ACF\u002FTPT)",{"label":15,"type":10,"description":16,"interventionNames":17},"Facility-based ACF\u002FTPT","ACF\u002FTPT intervention will be delivered on the grounds of a health facility (hospital or large public health center)",[13],{"label":19,"type":20,"description":21,"interventionNames":21},"No intervention","NO_INTERVENTION",null,[23],{"type":6,"name":24,"description":25,"armGroupLabels":26,"otherNames":21},"Active TB case finding with linkage to preventive therapy (ACF\u002FTPT)","ACF\u002FTPT in both intervention arms will consist of TB screening by mobile chest X-ray (with artificial intelligence-based reading, followed by confirmatory sputum testing with Xpert MTB\u002FRIF Ultra for participants with abnormal x-rays), and linkage to preventive therapy for those who are TB-negative and eligible for TPT (limited in April 2024 to those with close TB contact or known HIV infection).",[15,9],[28],{"name":29,"affiliation":5,"role":30},"Emily Kendall, MD PhD","PRINCIPAL_INVESTIGATOR",[32,37],{"name":33,"role":34,"phone":35,"phoneExt":21,"email":36},"Emily A Kendall, MD PhD","CONTACT","410-502-8234","ekendall@jhmi.edu",{"name":38,"role":34,"phone":21,"phoneExt":21,"email":39},"David W Dowdy, MD PhD","ddowdy1@jhmi.edu",[41],{"facility":42,"status":43,"city":44,"state":21,"zip":21,"country":45,"countryCode":46,"cosmosGeoPoint":47,"geoPoint":52,"contacts":53},"Walimu","RECRUITING","Kampala","Uganda","UG",{"type":48,"coordinates":49},"Point",[50,51],32.58219,0.31628,{"lat":51,"lon":50},[54,58],{"name":55,"role":34,"phone":56,"phoneExt":21,"email":57},"Achilles Katamba","256-414-530-021,","amkatamba@gmail.com",{"name":59,"role":30,"phone":21,"phoneExt":21,"email":21},"Achilles Katamba, MBChB PhD",{"type":61,"investigatorFullName":21,"investigatorTitle":21,"investigatorAffiliation":21,"oldNameTitle":21,"oldOrganization":21},"SPONSOR",[63,66],{"name":64,"class":65},"National Heart, Lung, and Blood Institute (NHLBI)","NIH",{"name":42,"class":6},"100461174","clinic-based-versus-hotspot-focused-active-tb-case-finding-100461174",false,"NCT05285202","Clinic-based Versus Hotspot-focused Active TB Case Finding","Clinic Versus Hotspot Active Case Finding and Linkage to Preventive Therapy (ACF\u002FTPT) Strategy Evaluation for TB: A Cluster-Randomized Crossover Trial","CHASE-TB","Inclusion Criteria:\n\n* Age ≥15 years, OR age 5-14 and a close contact of someone diagnosed with TB,\n* Provision of oral informed consent, or, if age \\\u003C18 years and not legally emancipated, oral informed assent (if ages 8-17) and parental informed consent (ages 5-17) to participate in the study\n* Ability to communicate with study staff in English or Luganda, or availability of a capable interpreter who is acceptable to the participant\n\nExclusion Criteria:\n\n* On treatment for, or diagnosed with but not yet treated for, active TB",true,"ALL","5 Years",{"count":79,"type":80},150000,"ESTIMATED","INTERVENTIONAL",[83],"NA","This five-year study will evaluate two strategies for conducting tuberculosis (TB) active case finding (ACF) and linkage to TB treatment or TB preventive therapy (TPT) in peri-urban Uganda. The two strategies differ in the location where ACF activities are performed: A \"facility-based\" ACF\u002FTPT strategy will perform ACF, plus linkage to TPT, in the immediate vicinity of a large public health facility and will primarily recruit individuals who are attending the health facility, irrespective of TB suspicion or symptoms. Alternatively, a \"hotspot-based\" strategy will use routine notification data and local expertise to identify local TB hotspots - defined as the geographic areas though to have the highest burden of undiagnosed TB per estimated population. The same infrastructure (personnel, equipment, supplies, etc.) for ACF\u002FTPT will then be placed in those zones for a period of four months at a time, and the general population will be recruited for screening and linkage to TPT.\n\nThe two interventions will be compared in a Type 1 hybrid effectiveness-implementation trial with a cluster-randomized, multiple-period crossover design. The study will evaluate whether hotspot-focused ACF\u002FTPT results in a greater number of TB patients diagnosed and linked to care, and a greater number of individuals started on preventive therapy, than facility-based ACF\u002FTPT. Secondarily, it will also compare the two interventions in terms of number of people initiated on TPT, and it will compare TB cases detected in regions performing ACF\u002FTPT (either approach) against cases detected in regions that continue to perform the standard of care.",[86,87],"Tuberculosis, Pulmonary","Mycobacterium Tuberculosis Infection","2026-05-27",{"date":90,"type":91},"2026-06-01","ACTUAL",{"date":93,"type":91},"2022-06-01",{"date":95,"type":80},"2026-11",{"name":5,"class":6},1]