[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100631380":3},{"organization":4,"armGroups":7,"interventions":16,"overallOfficials":11,"centralContacts":30,"locations":39,"responsibleParty":55,"collaborators":11,"id":57,"slug":58,"hasResults":59,"nctId":60,"briefTitle":61,"officialTitle":61,"acronym":62,"eligibilityCriteria":63,"healthyVolunteers":59,"sex":64,"minAge":65,"maxAge":11,"enrollmentInfo":66,"targetDuration":11,"studyType":69,"phases":70,"briefSummary":72,"conditions":73,"keywords":11,"overallStatus":75,"whyStopped":11,"lastUpdateSubmitDate":76,"lastUpdatePostDateStruct":77,"startDateStruct":80,"completionDateStruct":82,"leadSponsor":84,"locationsCount":85},{"fullName":5,"class":6},"Centre Leon Berard","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"Adult patient with rectal cancer undergoing surgery at Centre Léon Bérard from 2019","EXPERIMENTAL",null,[13,14,15],"Procedure: Blood sample collection","Procedure: Tumor Samples","Procedure: Healthy tissue sample",[17,22,26],{"type":18,"name":19,"description":20,"armGroupLabels":21,"otherNames":11},"PROCEDURE","Blood sample collection","Blood sample will be collected during a visit scheduled as part of the standard care for the patient",[9],{"type":18,"name":23,"description":24,"armGroupLabels":25,"otherNames":11},"Tumor Samples","Archival FFPE (Formalin-Fixed Paraffin-Embedded) or Fresh Frozen tumor samples from initial diagnosis, surgery, and metastases in case of relapse will be collected if available.",[9],{"type":18,"name":27,"description":28,"armGroupLabels":29,"otherNames":11},"Healthy tissue sample","A healthy tissue sample from the surgical site (excision margin) of the primary tumor or from an additionnal sample taken during preoperative rectosigmoidoscopy performed as part of the standard care will be collected.",[9],[31,36],{"name":32,"role":33,"phone":34,"phoneExt":11,"email":35},"Philippe CASSIER, MD","CONTACT","(+33)04 26 55 68 33","philippe.cassier@lyon.unicancer.fr",{"name":37,"role":33,"phone":11,"phoneExt":11,"email":38},"Lucas DE CRIGNIS, MD","lucas.decrignis@lyon.unicancer.fr",[40],{"facility":41,"status":11,"city":42,"state":11,"zip":11,"country":43,"countryCode":44,"cosmosGeoPoint":45,"geoPoint":50,"contacts":51},"Centre Léon Bérard","Lyon","France","FR",{"type":46,"coordinates":47},"Point",[48,49],4.84789,45.74906,{"lat":49,"lon":48},[52,54],{"name":32,"role":33,"phone":53,"phoneExt":11,"email":35},"(+33)4 26 55 68 33",{"name":37,"role":33,"phone":11,"phoneExt":11,"email":38},{"type":56,"investigatorFullName":11,"investigatorTitle":11,"investigatorAffiliation":11,"oldNameTitle":11,"oldOrganization":11},"SPONSOR","100631380","clinical-and-biogical-analyses-of-rectal-tumors-100631380",false,"NCT07499921","Clinical and BIOgical Analyses of RECtal Tumors","BIOREC","Inclusion Criteria:\n\n* Male or female aged 18 or over\n* Patients who have undergone surgery for rectal cancer since January 1st, 2019\n* Histological diagnosis of rectal adenocarcinoma confirmed on a surgical sample\n\nExclusion Criteria:\n\n* Not applicable","ALL","18 Years",{"count":67,"type":68},300,"ESTIMATED","INTERVENTIONAL",[71],"NA","Rectal cancer is a common cancer with an incidence of approximately 14,000 new cases per year in France. The survival rate is approximately 50% at 5 years, ranging from 90% for patients with localized rectal cancer to 18% for patients with metastases.\n\nSurgery with local or complete exicion is the standard treatment for early stages. The implementation of Total Neoadjuvant Therapy (TNT) for locally advanced stages has led to a significant improvement in the prognosis for rectal cancer. The complete pathological response rate of aproximately 20% after TNT has led to the \"Watch and Wait\" strategy, which aims to avoid surgery and preserve the rectum, but there is currently no reliable method for identifying responders. Rectal tumors with mismatch repair defiency (MMRd) and\u002For High microsatellite instability (MSI-H) are considered resistant to neoadjuvant chemotherapy, but those patients can benefit from immunotherapy treatment. Identifying patients who will respond to immunotherapy is crucial for this type of treatment. Pre-existing immune infiltration within the tumor microenvironnement prior to any treatment is an important prognostic factor and could help predict response to immunotherapy, as well as neoadjuvant treatment. Studying the immune microenvironnement and how it changes during different treatments could therefore help identify responders for whom treatment without surgery could be considered in order to avoid the deterioration in quality of life often associated with this procedure in this type of cancer. Finally, analysis of residual tumor cells after chemotherapy and\u002For chemoradiotherapy could help identify possible mechanisms of resistance to current treatments and develop strategies to counter them.",[74],"Rectal Cancer","NOT_YET_RECRUITING","2026-04-27",{"date":78,"type":79},"2026-04-30","ACTUAL",{"date":81,"type":68},"2026-05-01",{"date":83,"type":68},"2033-05-01",{"name":5,"class":6},1]