[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100617411":3},{"organization":4,"armGroups":7,"interventions":10,"overallOfficials":17,"centralContacts":24,"locations":30,"responsibleParty":45,"collaborators":10,"id":48,"slug":49,"hasResults":50,"nctId":51,"briefTitle":52,"officialTitle":53,"acronym":10,"eligibilityCriteria":54,"healthyVolunteers":55,"sex":56,"minAge":57,"maxAge":58,"enrollmentInfo":59,"targetDuration":10,"studyType":62,"phases":10,"briefSummary":63,"conditions":64,"keywords":68,"overallStatus":76,"whyStopped":10,"lastUpdateSubmitDate":77,"lastUpdatePostDateStruct":78,"startDateStruct":81,"completionDateStruct":83,"leadSponsor":85,"locationsCount":86},{"fullName":5,"class":6},"Gazi University","OTHER",[8,12,14],{"label":9,"type":10,"description":11,"interventionNames":10},"ACL Reconstruction Group",null,"Demographic data, injury history, and surgical details will be recorded for all participants. The International Physical Activity Questionnaire, IKDC, and ACL-RSI scales will be administered. Assessments will be completed over two days. Isokinetic knee flexor\u002Fextensor strength, fatigue protocol, and H\u002FQ ratios will be measured using the Cybex Norm dynamometer. Quadriceps and hamstring muscle oxygenation will be assessed with Train.Red NIRS. Knee proprioception will be evaluated via active joint repositioning, and postural control and dynamic stability will be measured using the KFORCE force platform. Knee laxity will be assessed with the GNRB arthrometer.",{"label":13,"type":10,"description":11,"interventionNames":10},"Primary ACL Repair Group",{"label":15,"type":10,"description":16,"interventionNames":10},"Healthy Control Group","Demographic data and physical activity levels will be recorded for healthy participants. All individuals will complete the International Physical Activity Questionnaire, IKDC, and ACL-RSI scales. Assessments will be conducted over two days. Knee flexor\u002Fextensor strength and H\u002FQ ratios will be measured using the Cybex Norm isokinetic dynamometer. Quadriceps and hamstring muscle oxygenation will be assessed with the Train.Red NIRS device. Knee proprioception will be measured using an active joint repositioning test, while postural control and dynamic stability will be evaluated with the KFORCE force platform. Knee laxity will be assessed using the GNRB arthrometer.",[18,21],{"name":19,"affiliation":5,"role":20},"Nihan Karatas, Prof. Dr.","STUDY_DIRECTOR",{"name":22,"affiliation":5,"role":23},"Dudu Ozdemir Can, MSc","PRINCIPAL_INVESTIGATOR",[25],{"name":26,"role":27,"phone":28,"phoneExt":10,"email":29},"Dudu Ozdemir Can, Msc","CONTACT","90 5534448492","duduozdemir@gazi.edu.tr",[31],{"facility":32,"status":10,"city":33,"state":34,"zip":35,"country":36,"countryCode":10,"cosmosGeoPoint":37,"geoPoint":42,"contacts":43},"Gazi University Faculty of Health Sciences Department of Physiotherapy and Rehabilitation","Ankara","Çankaya","06490","Turkey (Türkiye)",{"type":38,"coordinates":39},"Point",[40,41],32.85427,39.91987,{"lat":41,"lon":40},[44],{"name":22,"role":27,"phone":28,"phoneExt":10,"email":29},{"type":23,"investigatorFullName":46,"investigatorTitle":47,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"Dudu Özdemir","MSc.","100617411","clinical-and-functional-outcomes-after-acl-reconstruction-versus-primary-repair-100617411",false,"NCT07318272","Clinical and Functional Outcomes After ACL Reconstruction Versus Primary Repair","Comparison of Clinical and Functional Outcomes After Anterior Cruciate Ligament Reconstruction and Primary Repair Surgery","Inclusion Criteria for the ACL Reconstruction Group\n\n* Age 18-40 years\n* History of complete ACL rupture treated with ACL reconstruction\n* Surgery performed at Gazi University Department of Orthopedics and Traumatology\n* At least 12 months postoperative at the time of evaluation\n* Ability to comply with all study procedures\n* Signed informed consent\n\nExclusion Criteria for the ACL Reconstruction Group\n\n* Previous surgery for partial or chronic ACL tear\n* Concomitant multi-ligament knee injuries\n* Prior surgery on the ipsilateral or contralateral knee\n* Lower extremity malalignment (e.g., significant varus\u002Fvalgus)\n* Tibial avulsion-type ACL injury\n* Neurological or musculoskeletal disorders affecting lower limb function\n* Any medical condition that may interfere with test performance or safety\n\nInclusion Criteria for the Primary ACL Repair Group\n\n* Age 18-40 years\n* Complete ACL rupture treated with arthroscopic primary ACL repair\n* Surgery performed at Gazi University Department of Orthopedics and Traumatology\n* Minimum 12 months postoperative at the time of assessment A-bility to follow and complete study procedures\n* Signed informed consent\n\nExclusion Criteria for the Primary ACL Repair Group\n\n* Previous surgery for partial or chronic ACL injury\n* Multi-ligament knee injuries\n* History of surgery on either knee\n* Lower extremity malalignment\n* Tibial avulsion-type ACL rupture\n* Neuromuscular or musculoskeletal diseases affecting lower limb function or balance\n* Any condition that may affect participation or compromise safety\n\nInclusion Criteria for the Healthy Control Group\n\n* Age 18-40 years\n* No significant lower-extremity malalignment (e.g., varus\u002Fvalgus deformity)\n* No history of lower-extremity injury within the past 12 months\n* No known chronic systemic disease\n* No history of knee surgery or diagnosed knee pathology\n* Ability to understand and comply with study procedures\n* Signed informed consent\n\nExclusion Criteria for the Healthy Control Group\n\n* Presence of clinically significant lower-extremity malalignment\n* Lower-extremity musculoskeletal injury within the last 12 months\n* Any chronic systemic or metabolic disease\n* History of knee injury, knee surgery, or diagnosed knee pathology\n* Neurological, vestibular, or musculoskeletal disorder affecting balance or gait\n* Inability to complete study procedures",true,"ALL","18 Years","40 Years",{"count":60,"type":61},45,"ESTIMATED","OBSERVATIONAL","The anterior cruciate ligament (ACL) is the primary structure responsible for controlling anterior-posterior translation and rotational stability of the knee joint. Although ACL reconstruction has long been considered the gold standard among surgical interventions following ACL injury, arthroscopic primary repair techniques have recently regained interest. With advances in minimally invasive surgical procedures, refined patient selection criteria, and improved rehabilitation strategies, the clinical effectiveness of primary repair is once again being re-evaluated. However, there remains a limited body of literature directly comparing the medium- to long-term effects of these two surgical techniques on neuromuscular performance, fatigue tolerance, and functional outcomes.\n\nThe aim of this study is to comparatively investigate postoperative muscle strength and endurance, isokinetic fatigue response, muscle oxygenation, proprioception, knee stability, postural control, and patient-reported outcome measures in individuals who have undergone ACL reconstruction or primary repair. Assessments will include low- and high-velocity tests performed on the Cybex Norm isokinetic dynamometer, a 33-repetition fatigue protocol at 300°\u002Fs, muscle oxygenation analysis using Train.Red NIRS, knee laxity measurement via the GNRB arthrometer, single-leg balance and landing evaluations using the KFORCE force platform, and subjective outcome measures (IKDC, ACL-RSI).\n\nThe findings of this study are expected to provide a more comprehensive understanding of how surgical technique influences physiological, biomechanical, and functional outcomes. This knowledge may contribute to the development of individualized rehabilitation approaches and evidence-based return-to-sport criteria.",[65,66,67],"Anterior Cruciate Ligament (ACL) Tear","Anterior Cruciate Ligament Reconstruction","Isokinetic Test",[69,70,71,72,73,74,75],"ACL Injury","Anterior Cruciate Ligament","ACL Reconstruction","ACL Primary Repair","Postoperative Outcomes","Muscle Oxygenation","Isokinetic Testing","NOT_YET_RECRUITING","2025-12-28",{"date":79,"type":80},"2026-01-05","ACTUAL",{"date":82,"type":61},"2026-01-01",{"date":84,"type":61},"2027-08-30",{"name":5,"class":6},1]