[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100268233":3},{"organization":4,"armGroups":7,"interventions":10,"overallOfficials":21,"centralContacts":26,"locations":31,"responsibleParty":158,"collaborators":10,"id":160,"slug":161,"hasResults":162,"nctId":163,"briefTitle":164,"officialTitle":164,"acronym":10,"eligibilityCriteria":165,"healthyVolunteers":162,"sex":166,"minAge":167,"maxAge":168,"enrollmentInfo":169,"targetDuration":10,"studyType":172,"phases":10,"briefSummary":173,"conditions":174,"keywords":176,"overallStatus":34,"whyStopped":10,"lastUpdateSubmitDate":179,"lastUpdatePostDateStruct":180,"startDateStruct":183,"completionDateStruct":185,"leadSponsor":187,"locationsCount":188},{"fullName":5,"class":6},"National Institutes of Health Clinical Center (CC)","NIH",[8,11,13,16,19],{"label":9,"type":10,"description":9,"interventionNames":10},"Participants with cataracts",null,{"label":12,"type":10,"description":12,"interventionNames":10},"Participants with corneal dystrophies",{"label":14,"type":10,"description":15,"interventionNames":10},"Participants with glaucoma","Participants with glaucoma or other anterior chamber anomalies",{"label":17,"type":10,"description":18,"interventionNames":10},"Participants with lens refractive errors","Participants with lens refractive errors including myopia and hyperopia",{"label":20,"type":10,"description":20,"interventionNames":10},"Participants with retinal degenerations",[22],{"name":23,"affiliation":24,"role":25},"James F Hejtmancik, M.D.","National Eye Institute (NEI)","PRINCIPAL_INVESTIGATOR",[27],{"name":23,"role":28,"phone":29,"phoneExt":10,"email":30},"CONTACT","(301) 435-1598","f3h@helix.nih.gov",[32,51,67,78,88,98,109,121,137,148],{"facility":33,"status":34,"city":35,"state":36,"zip":37,"country":38,"countryCode":39,"cosmosGeoPoint":40,"geoPoint":45,"contacts":46},"University of California, San Diego","RECRUITING","La Jolla","California","92093-0603","United States","US",{"type":41,"coordinates":42},"Point",[43,44],-117.2742,32.84727,{"lat":44,"lon":43},[47],{"name":48,"role":28,"phone":49,"phoneExt":10,"email":50},"Radha Ayyagari, Ph.D.","858-534-9029","rayyagari@ucsd.edu",{"facility":52,"status":34,"city":53,"state":54,"zip":55,"country":38,"countryCode":39,"cosmosGeoPoint":56,"geoPoint":60,"contacts":61},"National Institutes of Health Clinical Center","Bethesda","Maryland","20892",{"type":41,"coordinates":57},[58,59],-77.10026,38.98067,{"lat":59,"lon":58},[62],{"name":63,"role":28,"phone":64,"phoneExt":65,"email":66},"For more information at the NIH Clinical Center contact Office of Patient Recruitment (OPR)","800-411-1222","TTY8664111010","prpl@cc.nih.gov",{"facility":68,"status":69,"city":70,"state":71,"zip":72,"country":38,"countryCode":39,"cosmosGeoPoint":73,"geoPoint":77,"contacts":10},"Duke University Eye Center","WITHDRAWN","Durham","North Carolina","27708",{"type":41,"coordinates":74},[75,76],-78.89862,35.99403,{"lat":76,"lon":75},{"facility":79,"status":34,"city":80,"state":10,"zip":10,"country":81,"countryCode":82,"cosmosGeoPoint":83,"geoPoint":87,"contacts":10},"Eye Research Institute, Zhongshan Ophthalmic Center, Sun Yat Sen University","Guangzhou","China","CN",{"type":41,"coordinates":84},[85,86],113.25,23.11667,{"lat":86,"lon":85},{"facility":89,"status":69,"city":90,"state":10,"zip":10,"country":91,"countryCode":92,"cosmosGeoPoint":93,"geoPoint":97,"contacts":10},"Aravind Medical Research Foundation","Madurai","India","IN",{"type":41,"coordinates":94},[95,96],78.11953,9.919,{"lat":96,"lon":95},{"facility":99,"status":69,"city":100,"state":10,"zip":101,"country":102,"countryCode":103,"cosmosGeoPoint":104,"geoPoint":108,"contacts":10},"Seconda Universita di Napoli","Naples","80014","Italy","IT",{"type":41,"coordinates":105},[106,107],14.26811,40.85216,{"lat":107,"lon":106},{"facility":110,"status":111,"city":112,"state":10,"zip":113,"country":114,"countryCode":115,"cosmosGeoPoint":116,"geoPoint":120,"contacts":10},"National Centre of Excellence in Molecular Biology, University of the Punjab","SUSPENDED","Lahore","53700","Pakistan","PK",{"type":41,"coordinates":117},[118,119],74.35071,31.558,{"lat":119,"lon":118},{"facility":122,"status":34,"city":123,"state":10,"zip":124,"country":125,"countryCode":126,"cosmosGeoPoint":127,"geoPoint":131,"contacts":132},"University of the Philippines","Manila","4031","Philippines","PH",{"type":41,"coordinates":128},[129,130],120.9822,14.6042,{"lat":130,"lon":129},[133],{"name":134,"role":28,"phone":135,"phoneExt":10,"email":136},"Leo Cubillan, M.D.","63-2-5247119","lcubillan@upm.edu.ph",{"facility":138,"status":34,"city":139,"state":10,"zip":140,"country":141,"countryCode":142,"cosmosGeoPoint":143,"geoPoint":147,"contacts":10},"The Filatov Institute of Eye Disease and Tissue Therapy of the National Academy","Odesa","6500","Ukraine","UA",{"type":41,"coordinates":144},[145,146],30.74383,46.48572,{"lat":146,"lon":145},{"facility":149,"status":111,"city":150,"state":10,"zip":10,"country":151,"countryCode":152,"cosmosGeoPoint":153,"geoPoint":157,"contacts":10},"University of Exeter","Exeter","United Kingdom","UK",{"type":41,"coordinates":154},[155,156],-3.52751,50.7236,{"lat":156,"lon":155},{"type":159,"investigatorFullName":10,"investigatorTitle":10,"investigatorAffiliation":10,"oldNameTitle":10,"oldOrganization":10},"SPONSOR","100268233","clinical-and-molecular-studies-in-families-with-inherited-eye-disease-100268233",false,"NCT02771236","Clinical and Molecular Studies in Families With Inherited Eye Disease","* INCLUSION CRITERIA:\n\nTo be eligible, the following inclusion criteria must be met, where applicable;\n\n1. Participant must be four years of age or older.\n2. Participant must understand and sign the protocol s informed consent document.\n3. Individuals or family members of individuals with inherited eye diseases, either congenital, childhood, or age related.\n4. All participants must be able to cooperate with study examination and phlebotomy.\n\nEXCLUSION CRITERIA:\n\nA participant is not eligible if any of the following exclusion criteria are present:\n\n1. Participant has a disease, infection, or trauma that mimics inherited cataracts, retinal degenerations, glaucoma, etc.\n2. Participant has a significant active infection (an infection requiring treatment as determined by the investigator) or a history of chronic or recurrent infections.\n3. Participant requires sedation for study purposes.","ALL","4 Years","120 Years",{"count":170,"type":171},5000,"ESTIMATED","OBSERVATIONAL","Background:\n\nGenes are the basic units of heredity. When genes are changed, certain cells don t work like they should. Researchers want to try to better understand the genetic conditions that are linked with inherited eye diseases.\n\nObjective:\n\nTo try to identify the genes linked to the development of inherited eye diseases.\n\nEligibility:\n\nPeople ages 4 and older who have or have a family member with an inherited eye disease\n\nDesign:\n\nParticipants will be screened with medical history and medical records.\n\nParticipants will have one visit that will take 3-4 hours. This will include:\n\nMedical and family history\n\nEye exam: This includes the pupil being dilated.\n\nElectroretinography: A small electrode is taped to the forehead. Participants sit in the\n\ndark with their eyes patched for 30 minutes. Then numbing drops and contact lenses are put in\n\nthe eyes. They will watch flashing lights.\n\nBlood tests\n\nSaliva sample: They will spit into a container or have the inside of their cheek swabbed.\n\nGenetic testing will be done on participants blood or saliva.\n\nParticipants may meet with the researchers to discuss their genetic tests.\n\n...",[175],"Inherited Eye Disease",[177,178],"Genetics","Natural History","2026-07-01",{"date":181,"type":182},"2026-07-02","ACTUAL",{"date":184,"type":182},"2016-10-04",{"date":186,"type":171},"2032-01-01",{"name":24,"class":6},10]