[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100583083":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":26,"centralContacts":31,"locations":37,"responsibleParty":48,"collaborators":52,"id":55,"slug":56,"hasResults":57,"nctId":58,"briefTitle":59,"officialTitle":60,"acronym":26,"eligibilityCriteria":61,"healthyVolunteers":62,"sex":63,"minAge":64,"maxAge":65,"enrollmentInfo":66,"targetDuration":26,"studyType":69,"phases":70,"briefSummary":72,"conditions":73,"keywords":79,"overallStatus":88,"whyStopped":26,"lastUpdateSubmitDate":89,"lastUpdatePostDateStruct":90,"startDateStruct":93,"completionDateStruct":95,"leadSponsor":97,"locationsCount":98},{"fullName":5,"class":6},"Cairo University","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Group 1 (Potassium Nitrate in Polycarboxylate cement)","EXPERIMENTAL","Potassium nitrate (KNO3) is a superior desensitizer for hypersensitive teeth. Used with polycarboxylate cement, it serves as an effective liner for deep carious lesions. Also when placed under deep restorations with less than 1 mm of protective dentin remaining, it was effective in preserving pulpal vitality and it diminished the incidence and severity of post-restoration pain. As temporary cement (Kno3\u002Fzinc oxide eugenol \\[ZOE\\]) It reduced pain following full crown preparation.",[13],"Combination Product: Potassium Nitrate in Polycarboxylate cement",{"label":15,"type":16,"description":17,"interventionNames":18},"Group 2 (Mineral Trioxide Aggregates \"MTA\")","ACTIVE_COMPARATOR","Mineral trioxide aggregate (MTA) has been recommended as the gold standard for vital pulp therapy as it showed a high success rate clinically and radiographically when compared to other materials due to its biocompatibility, antibacterial properties and excellent sealing ability",[19],"Other: MTA-Anglus",[21,27],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"COMBINATION_PRODUCT","Potassium Nitrate in Polycarboxylate cement","The application of polycarboxylate cement containing 5% KNO3 for direct capping of traumatically exposed pulp in animal models did not result in any degenerative changes in dental pulp, thought creating optimal conditions for preservation of pulp vitality.\n\nPolycarboxylate cement has very thin film thickness and bonds firmly to the tooth structure, is capable of withstanding the overlying pressure during restoration procedures. The good adhesive properties of polycarboxylate cement containing 5% KNO3 guaranteed the closure of cavity, good and lasting protection of traumatically exposed dental pulp and the formation of alkaline environment possessing a strong antiacidic, anti-inflammatory and antibacterial effect of this pulp capping material, creating optimal conditions for expression of its natural reparative potential. The increased release of potassium nitrate from polycarboxylate cement by time, might be the cause of decreasing the inflammatory intensity",[9],null,{"type":6,"name":28,"description":29,"armGroupLabels":30,"otherNames":26},"MTA-Anglus","Mineral Trioxide Aggregate (MTA) has been the gold standard material for primary tooth pulpotomy. MTA has antimicrobial properties, excellent sealing ability, is biocompatible and has a dentinogenic effect on pulp tissue by stimulating the release of cytokines from bone cells, which promotes hard tissue formation. Furthermore, MTA maintains pulp tissue integrity while having no cytotoxic effects. Nevertheless, the clinical application of MTA has been limited due to some properties such as its long setting time, difficulty in its handling, being washed out, discoloration, and increased cost. These urged the search for an alternative pulpotomy material to MTA",[15],[32],{"name":33,"role":34,"phone":35,"phoneExt":26,"email":36},"Mariam M El-Mosallamy, bachelor's degree in dentistry","CONTACT","+201066761063","mariamm.ahmoud@dentistry.cu.edu.eg",[38],{"facility":5,"status":26,"city":39,"state":26,"zip":26,"country":40,"countryCode":41,"cosmosGeoPoint":42,"geoPoint":47,"contacts":26},"Cairo","Egypt","EG",{"type":43,"coordinates":44},"Point",[45,46],31.24967,30.06263,{"lat":46,"lon":45},{"type":49,"investigatorFullName":50,"investigatorTitle":51,"investigatorAffiliation":5,"oldNameTitle":26,"oldOrganization":26},"PRINCIPAL_INVESTIGATOR","Mariam Mahmoud Salah El-Mosallamy","Dentist",[53],{"name":54,"class":6},"National Research Centre, Egypt","100583083","clinical-and-radiographic-evaluation-of-potassium-nitrate-in-polycarboxylate-versus-mineral-trioxide-aggregate-in-vital-pulpotomy-in-primary-molars-100583083",false,"NCT06871709","Clinical and Radiographic Evaluation of Potassium Nitrate in Polycarboxylate Versus Mineral Trioxide Aggregate in Vital Pulpotomy in Primary Molars","Clinical and Radiographic Evaluation of Potassium Nitrate in Polycarboxylate Versus Mineral Trioxide Aggregate in Vital Pulpotomy in Primary Molars: a Randomized Clinical Trial","❖ Inclusion Criteria:\n\n1. Children aged 4 to 7 years, in good general health.\n2. Children with vital, deeply carious primary molars.\n3. No history of spontaneous pain, pathological mobility, draining sinus tract, redness or swelling of the vestibule.\n4. Normal gingival and periodontal condition, with no sensitivity to vestibular palpation, and no pain on percussion test.\n5. No sign of radiolucency in periapical or furcation area.\n6. No widening of PDL space or loss of lamina dura continuity.\n7. No evidence of internal\u002Fexternal pathological root resorption.\n\nExclusion Criteria:\n\n1. Children with a physical disability or medical disability.\n2. Unrestorable molars.\n3. Uncooperative patient.\n4. Parent unable to attend Follow- up visits.\n5. Parents refuse to give written informed consent.\n6. If the access was opened and irreversible pulpitis was evident.",true,"ALL","4 Years","7 Years",{"count":67,"type":68},50,"ESTIMATED","INTERVENTIONAL",[71],"NA","The purpose of this RCT is to compare the clinical\u002Fradiographic outcomes of Potassium nitrate in polycarboxylate cement and MTA as pulpotomy biomaterials used for asymptomatic vital primary lower second molar and this will help to clinically evaluate the use of alternative material in vital pulpotomy in primary molars with deep carious cavities.\n\nEmphasis is set on avoiding total pupectomy and maintaining radicular pulp vitality therefore maintain the tooth in a viable condition till it's shedding and eruption of the permanent successor.",[74,75,76,77,78],"Vital Pulp Therapies","Pulpotomy","Pulp Disease, Dental","Pulpotomies Primary Teeth","Pulp Therapy",[80,81,82,75,83,84,85,86,87],"Mineral Trioxide Aggregate","Potassium Nitrate","MTA","Vital Pulpotomy","Vital Pulp therapy","Primary Molars","pulp therapy","Pulp disease","NOT_YET_RECRUITING","2025-03-06",{"date":91,"type":92},"2025-03-12","ACTUAL",{"date":94,"type":68},"2025-05-30",{"date":96,"type":68},"2026-12-30",{"name":5,"class":6},1]