[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100602640":3},{"organization":4,"armGroups":7,"interventions":14,"overallOfficials":10,"centralContacts":10,"locations":10,"responsibleParty":19,"collaborators":10,"id":23,"slug":24,"hasResults":25,"nctId":26,"briefTitle":27,"officialTitle":27,"acronym":28,"eligibilityCriteria":29,"healthyVolunteers":25,"sex":30,"minAge":31,"maxAge":32,"enrollmentInfo":33,"targetDuration":36,"studyType":37,"phases":10,"briefSummary":38,"conditions":39,"keywords":10,"overallStatus":42,"whyStopped":10,"lastUpdateSubmitDate":43,"lastUpdatePostDateStruct":44,"startDateStruct":47,"completionDateStruct":49,"leadSponsor":51,"locationsCount":10},{"fullName":5,"class":6},"RenJi Hospital","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"AIDs patients",null,"Patients with Still's disease must meet the 1992 Yamaguchi diagnostic criteria; patients with monogenic autoinflammatory diseases must meet the confirmed diagnostic criteria for the respective conditions; all patients must provide written informed consent.；Age range: 18-75 years old patients with autoinflammatory diseases.",[13],"Other: Not applicable- observational study",[15],{"type":6,"name":16,"description":17,"armGroupLabels":18,"otherNames":10},"Not applicable- observational study","no interventions were involved",[9],{"type":20,"investigatorFullName":21,"investigatorTitle":22,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"PRINCIPAL_INVESTIGATOR","Qiong Fu","Director","100602640","clinical-autoinflammatory-disease-cohort-100602640",false,"NCT07126145","Clinical Autoinflammatory Disease Cohort","CAID","Inclusion Criteria:\n\n* Diagnosis of adult-onset Still's disease (AOSD) according to the Yamaguchi criteria (as described above) or other established autoinflammatory disease diagnostic criteria.\n* Age between 18 and 75 years, inclusive.\n* Willingness and ability to comply with scheduled follow-up visits, examinations, and treatments.\n* Voluntary provision of written informed consent.\n\nExclusion Criteria:\n\n* Refusal or inability to provide informed consent; age under 18 or over 75 years; inability to provide at least 80% of the required core data for Still's disease or other autoinflammatory diseases.\n* Presence of other connective tissue diseases.\n* Positive detection of autoantibodies.\n* Current acute infection or history of active tuberculosis.\n* History of allergic constitution or multiple drug allergies.\n* Psychiatric disorders or other conditions preventing compliance with examinations, follow-up, or treatment.\n* Women who are currently pregnant or planning to become pregnant.\n* Presence of malignant tumors.\n* Participation in other clinical trials currently or within a specified washout period.","ALL","18 Years","75 Years",{"count":34,"type":35},1000,"ESTIMATED","12 Months","OBSERVATIONAL","Autoinflammatory diseases (AIDs) are a group of rare disorders caused by dysregulation of the innate immune system, characterized by recurrent fever, systemic inflammation, and involvement of specific organs. Diagnosis relies on a combination of clinical features, laboratory tests, genetic findings, and response to treatment. Still's disease is a representative type of AID, marked by high spiking fevers, polyarthritis, evanescent rash, and markedly elevated inflammatory markers. Among its complications, macrophage activation syndrome (MAS) is the most life-threatening, affecting approximately 10-15% of patients. MAS involves uncontrolled immune activation and systemic inflammation, and if left untreated, may result in a mortality rate exceeding 50%. This study aims to develop a standardized clinical dataset and diagnostic-treatment framework for AIDs based on their disease characteristics. After establishing a data collection template, eligible patients aged 18-75 years with AIDs will be enrolled. Clinical data will be collected to build a prospective follow-up cohort, focusing particularly on adult-onset Still's disease (AOSD), to explore the clinical features and pathogenesis of AIDs.",[40,41],"Still Disease","Autoinflammatory Disease","NOT_YET_RECRUITING","2025-08-10",{"date":45,"type":46},"2025-08-17","ACTUAL",{"date":48,"type":35},"2025-08",{"date":50,"type":35},"2035-08",{"name":5,"class":6}]