[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100621847":3},{"organization":4,"armGroups":7,"interventions":22,"overallOfficials":28,"centralContacts":35,"locations":41,"responsibleParty":73,"collaborators":28,"id":76,"slug":77,"hasResults":78,"nctId":79,"briefTitle":80,"officialTitle":81,"acronym":82,"eligibilityCriteria":83,"healthyVolunteers":78,"sex":84,"minAge":85,"maxAge":86,"enrollmentInfo":87,"targetDuration":28,"studyType":90,"phases":91,"briefSummary":93,"conditions":94,"keywords":28,"overallStatus":44,"whyStopped":28,"lastUpdateSubmitDate":96,"lastUpdatePostDateStruct":97,"startDateStruct":100,"completionDateStruct":102,"leadSponsor":104,"locationsCount":105},{"fullName":5,"class":6},"Meyer Children's Hospital IRCCS","OTHER",[8,13,18],{"label":9,"type":6,"description":10,"interventionNames":11},"Pediatric Behçet Disease Patients","Pediatric patients (\\\u003C18 years) with a diagnosis of Behçet disease. Blood samples collected during routine clinical visits will be analyzed for research purposes, including cytokine profiling, circulating microRNA analysis, DNA methylation profiling, and genetic sequencing. These analyses are not used for clinical decision-making.",[12],"Diagnostic Test: Biomarker analysis of blood samples",{"label":14,"type":15,"description":16,"interventionNames":17},"Adult Behçet Disease Patients","EXPERIMENTAL","Adult patients (≥18 years) with a diagnosis of Behçet disease. Blood samples collected during routine clinical visits will be analyzed for research purposes, including cytokine profiling, circulating microRNA analysis, DNA methylation profiling, and genetic sequencing. These analyses are not used for clinical decision-making",[12],{"label":19,"type":15,"description":20,"interventionNames":21},"Healthy Pediatric Controls","Healthy pediatric subjects (\\\u003C18 years) undergoing routine blood testing for non-inflammatory conditions. Blood samples will be analyzed for research purposes, including circulating microRNA analysis and DNA methylation profiling, and used as reference controls for comparative analyses.",[12],[23,29,32],{"type":24,"name":25,"description":26,"armGroupLabels":27,"otherNames":28},"DIAGNOSTIC_TEST","Biomarker analysis of blood samples","Research laboratory analyses will be performed on blood samples collected during routine clinical care.\n\nFor pediatric Behçet disease patients, analyses include cytokine profiling (IL-6, IL-10, IL-17, TNF-α), circulating microRNA profiling, DNA methylation profiling, and targeted genetic sequencing for genes associated with monogenic Behçet-like phenotypes.",[19],null,{"type":24,"name":25,"description":30,"armGroupLabels":31,"otherNames":28},"Research laboratory analyses will be performed on blood samples collected during routine clinical care.\n\nFor Adult Behçet disease patients, analyses include cytokine profiling (IL-6, IL-10, IL-17, TNF-α), circulating microRNA profiling, DNA methylation profiling, and targeted genetic sequencing for genes associated with monogenic Behçet-like phenotypes.",[14],{"type":24,"name":25,"description":33,"armGroupLabels":34,"otherNames":28},"Research laboratory analyses will be performed on blood samples collected during routine clinical care.\n\nFor healthy pediatric controls, analyses are limited to circulating microRNA profiling and DNA methylation profiling only; no genetic testing\u002FDNA sequencing will be performed in this group.",[9],[36],{"name":37,"role":38,"phone":39,"phoneExt":28,"email":40},"Gabriele Simonini","CONTACT","+390555662545","gabriele.simonini@unifi.it",[42,57],{"facility":43,"status":44,"city":45,"state":45,"zip":46,"country":47,"countryCode":48,"cosmosGeoPoint":49,"geoPoint":54,"contacts":55},"Aou Meyer IRCSS","RECRUITING","Florence","50139","Italy","IT",{"type":50,"coordinates":51},"Point",[52,53],11.24626,43.77925,{"lat":53,"lon":52},[56],{"name":37,"role":38,"phone":39,"phoneExt":28,"email":28},{"facility":58,"status":59,"city":60,"state":60,"zip":28,"country":61,"countryCode":62,"cosmosGeoPoint":63,"geoPoint":67,"contacts":68},"Alder Hey Children's Hospital,","NOT_YET_RECRUITING","Liverpool","United Kingdom","UK",{"type":50,"coordinates":64},[65,66],-2.97794,53.41058,{"lat":66,"lon":65},[69],{"name":70,"role":38,"phone":71,"phoneExt":28,"email":72},"Christian Hedrich","+44 (0) 151 794 2000","chedrich@liverpool.ac.uk",{"type":74,"investigatorFullName":37,"investigatorTitle":75,"investigatorAffiliation":5,"oldNameTitle":28,"oldOrganization":28},"PRINCIPAL_INVESTIGATOR","MD","100621847","clinical-biochemical-and-epigenetic-profile-of-pediatric-behet-disease-100621847",false,"NCT07375940","Clinical, Biochemical and Epigenetic Profile of Pediatric Behçet Disease","Clinical, Biochemical and Epigenetic Profile of Pediatric Behçet Disease: Similarities and Differences From Adult Patients and Looking for Potential Biomarkers.","PED-BD","Cases Inclusion Criteria :\n\n* BD diagnosis according to at least one of the three sets of classification criteria \\[International Criteria for Behçet's Disease (ICBD), International Study Group (ISG) and Pediatric Behçet's disease criteria PEDBD)\\];\n* Age 6 months to 70 years old.\n* Written informed consent from appropriate legal representative(s), and assent from patients who have not reached the age of consent.\n\nCases Exclusion Criteria:\n\n* Patients who do not meet the BD criteria OR\n* Patients for whom an alternative diagnosis was not investigated and\u002For excluded OR\n* Absence of a written informed consent.\n\nHealthy pediatric controls:\n\n* Patients evaluated at the Meyer Children's Hospital IRCCS Rheumatology Outpatient Clinic who are scheduled to undergo routine hematochemical tests, not for suspected inflammatory or autoimmune conditions.\n* Age \\\u003C 18 years, matched 1:1 by age and sex with the pediatric Behçet disease (BD) cohort.\n* Absence of recent or ongoing inflammatory conditions, verified through structured medical history and physical examination.\n* No clinical signs suggestive of chronic autoinflammatory or autoimmune diseases at physical examination .\n* No recent prolonged use (more than 7 consecutive days within the past 4 weeks) of anti-inflammatory, glucocorticoids, immunomodulatory, therapies or antibiotics.\n* Written informed consent from the legal guardian(s) and assent from minors when appropriate.\n\nHealthy Controls Exclusion Criteria\n\n* Diagnosis of acute or chronic inflammatory, autoimmune, or autoinflammatory conditions after the collection of structured medical history and physical examination\n* Current or recent prolonged use (more than 7 consecutive days within the past 4 weeks) of anti-inflammatory drugs, gluccocorticoids, immunomodulatory agents, or antibiotics.\n* Routine blood tests not performed during the visit.\n* Absence of written informed consent.","ALL","6 Months","70 Years",{"count":88,"type":89},90,"ESTIMATED","INTERVENTIONAL",[92],"NA","Behçet disease (BD) is a chronic multisystem inflammatory disorder with a relapsing-remitting course. Pediatric-onset BD is rare and characterized by marked clinical heterogeneity, frequent incomplete presentation at disease onset, and limited availability of pediatric-specific outcome measures and biomarkers.\n\nThis prospective multicenter study aims to comprehensively characterize the clinical, biochemical, genetic, and epigenetic profiles of pediatric patients with Behçet disease and to compare them with adult BD patients and healthy pediatric controls.\n\nThe study focuses on the identification of disease-associated cytokine patterns, circulating microRNA profiles, DNA methylation signatures, and genetic variants associated with monogenic autoinflammatory diseases presenting with a Behçet-like phenotype.\n\nBy integrating clinical data with multi-omic analyses, this study seeks to identify biologically and clinically meaningful patient subgroups, improve disease stratification, and explore potential biomarkers of disease activity and remission in pediatric Behçet disease.",[95],"Behcet Disease and Vascular Involvement","2026-01-22",{"date":98,"type":99},"2026-01-29","ACTUAL",{"date":101,"type":99},"2026-01-12",{"date":103,"type":89},"2036-01",{"name":5,"class":6},2]