[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100621995":3},{"organization":4,"armGroups":7,"interventions":14,"overallOfficials":19,"centralContacts":24,"locations":10,"responsibleParty":33,"collaborators":10,"id":35,"slug":36,"hasResults":37,"nctId":38,"briefTitle":39,"officialTitle":39,"acronym":40,"eligibilityCriteria":41,"healthyVolunteers":37,"sex":42,"minAge":43,"maxAge":44,"enrollmentInfo":45,"targetDuration":48,"studyType":49,"phases":10,"briefSummary":50,"conditions":51,"keywords":54,"overallStatus":59,"whyStopped":10,"lastUpdateSubmitDate":60,"lastUpdatePostDateStruct":61,"startDateStruct":64,"completionDateStruct":66,"leadSponsor":68,"locationsCount":10},{"fullName":5,"class":6},"Eighth Affiliated Hospital, Sun Yat-sen University","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"Retrospective NTM Cohort",null,"This cohort consists of approximately 1,500 patients diagnosed with nontuberculous mycobacterial (NTM) across multiple hospitals in South China. Data, including demographics, clinical symptoms, imaging findings, microbiology results, and treatment outcomes, will be extracted retrospectively from electronic medical records for the period from January 2015 to May 2025.",[13],"Other: Prospective Biospecimen Sub-cohort",[15],{"type":6,"name":16,"description":17,"armGroupLabels":18,"otherNames":10},"Prospective Biospecimen Sub-cohort","Observational",[9],[20],{"name":21,"affiliation":22,"role":23},"Jianquan Zhang","The Eighth Affiliated Hospital of Sun Yat-sen University","STUDY_CHAIR",[25,30],{"name":26,"role":27,"phone":28,"phoneExt":10,"email":29},"Jianquan Zhang, Dr","CONTACT","0755-83982222","jqzhang2002@126.com",{"name":31,"role":27,"phone":10,"phoneExt":10,"email":32},"Mianluan Dr Pan, Dr","2693754132@qq.com",{"type":34,"investigatorFullName":10,"investigatorTitle":10,"investigatorAffiliation":10,"oldNameTitle":10,"oldOrganization":10},"SPONSOR","100621995","clinical-characteristics-and-immune-escape-mechanism-of-nontuberculous-mycobacterial-lung-disease-in-south-china-100621995",false,"NCT07377864","Clinical Characteristics and Immune Escape Mechanism of Nontuberculous Mycobacterial Lung Disease in South China","NTM-LD","Inclusion Criteria:1. (Both Cohorts):\n\n* Patients diagnosed with nontuberculous mycobacterial according to standard guidelines.\n* Aged 18 years or older.\n* Available medical records covering the period from 2015 to 2025 (for the retrospective cohort).\n\n  2\\. (Prospective Sub-cohort Additional):\n* Willing and able to provide written informed consent for biospecimen collection.\n* Clinically stable and suitable for undergoing research bronchoalveolar lavage (BAL) procedure, as judged by the investigator.\n\nExclusion Criteria: 1. (Both Cohorts):\n\n* Active tuberculosis or other dominant pulmonary infections.\n* Incomplete medical records that preclude adequate data extraction (for retrospective analysis).\n\n  2\\. (Prospective Sub-cohort Additional):\n* Contraindications to bronchoscopy or BAL procedure.\n* Pregnancy or lactation.\n* Any condition that, in the opinion of the investigator, would compromise patient safety or data integrity.","ALL","18 Years","80 Years",{"count":46,"type":47},1500,"ESTIMATED","12 Months","OBSERVATIONAL","Nontuberculous Mycobacterial lung disease (NTM-LD) is a significant infectious challenge. The precise causes remain unclear, diagnosis can be complex, treatment outcomes are often unsatisfactory, and the disease can severely affect a patient's quality of life. Environmental factors, such as the warm and humid climate in South China, may contribute to unique characteristics of NTM in this region, but systematic research is currently lacking.\n\nThis study aims to improve the understanding of NTM-LD in South China. It consists of two complementary parts:\n\n1. The first part is a retrospective review of medical records from approximately 1,500 NTM patients across multiple hospitals in South China. This analysis seeks to identify common patterns in symptoms, diagnostic findings, and treatment responses within this population.\n2. The second part is a prospective study involving about 106 current NTM-LD patients. Blood and lung fluid samples will be collected to analyze, using advanced laboratory techniques, how the patient's immune system responds to the infection. This investigation aims to uncover clues about why some cases are difficult to treat.\n\nThe overall goal of this research is to generate evidence that can aid healthcare providers in South China in diagnosing and managing NTM-LD more effectively. Please note that this is an observational study; no new drugs or experimental treatments are being tested.",[52,53],"Nontuberculous Mycobacterial Lung Disease","Mycobacterium Avium Complex (MAC)",[55,56,57,58],"Nontuberculous Mycobacterial","South China","Immune Escape","Outcome","NOT_YET_RECRUITING","2026-01-28",{"date":62,"type":63},"2026-01-30","ACTUAL",{"date":65,"type":47},"2026-01-01",{"date":67,"type":47},"2028-12-31",{"name":5,"class":6}]