[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100484013":3},{"organization":4,"armGroups":7,"interventions":30,"overallOfficials":35,"centralContacts":39,"locations":46,"responsibleParty":63,"collaborators":10,"id":65,"slug":66,"hasResults":67,"nctId":68,"briefTitle":69,"officialTitle":69,"acronym":10,"eligibilityCriteria":70,"healthyVolunteers":71,"sex":72,"minAge":10,"maxAge":73,"enrollmentInfo":74,"targetDuration":77,"studyType":78,"phases":10,"briefSummary":79,"conditions":80,"keywords":84,"overallStatus":48,"whyStopped":10,"lastUpdateSubmitDate":88,"lastUpdatePostDateStruct":89,"startDateStruct":92,"completionDateStruct":94,"leadSponsor":96,"locationsCount":97},{"fullName":5,"class":6},"National Taiwan University Hospital","OTHER",[8,14,18,22,26],{"label":9,"type":10,"description":11,"interventionNames":12},"Clinical Characteristics of pediatric COVID-19 by the retrospective research group",null,"Analyze all clinically visible data of hospitalized children with COVID-19 infection (different virus strains), and then find the cause of severe disease and related risk factors for disease",[13],"Other: sequelae tracking",{"label":15,"type":10,"description":16,"interventionNames":17},"acute case receiving group (including children with multisystem inflammatory syndrome)","1. The correlation between the microbial flora of the respiratory tract and the central nervous system and the severity of SARS-CoV2 pneumonia and host immunity (host inflammatory biomarkers, antibody library\u002Fcell receptor library, chemokines, cytokines, cell-regulated immune responses, table Epitope mapping, host transcriptome studies)\n2. To explore the correlation between the clinical manifestations of gastrointestinal tract and liver and SARS-CoV-2 infection and the analysis of gut microbiota\n3. To analyze the host gene factors of COVID-19 patients.\n4. To explore the changes of brain injury biomarkers (Biomarker) in acute and chronic phases, and to analyze the correlation with changes in brain structure and other clinical factors (e.g. severity of neurological symptoms)",[13],{"label":19,"type":10,"description":20,"interventionNames":21},"children's long COVID-19 tracking group","1. Clarify the incidence and persistent impact of COVID-19 symptoms in children through outpatient assessment, and further analyze the factors related to preventing the development of COVID-19. \u002F Conduct long-term follow-up through brain MRI and neurophysiological examinations to explore the effects of COVID-19 infection on children brain structure and peripheral nerve function, and analyze the association of risk factors and other clinical symptoms. A psychiatric clinical diagnostic interview was also conducted to establish a psychiatric diagnosis. The emotional and behavioral assessment scale was used to fully evaluate the mental state and family social function.\n2. To analyze the correlation between host genes and antibody repertoire\u002Freceptor repertoire, epitope mapping, microbial phase, and prognosis of severe COVID-19 patients",[13],{"label":23,"type":10,"description":24,"interventionNames":25},"seroepidemiological research group","Through the antibody test and the content of the questionnaire, we can better understand the epidemiology of the COVID-19. Including the proportion of asymptomatic infections, the scale of infection, the speed of transmission, etc. Vaccinated people can also learn about the speed of antibody decline",[13],{"label":27,"type":10,"description":28,"interventionNames":29},"healthy control group","Provide a sample of the normal population of the \"Acute Reception Unit\". To carry out respiratory microbial flora, host inflammatory biomarkers, antibody library\u002Freceptor library, chemokines, cytokines, cell-mediated immune responses, epitope mapping, brain MRI, neurophysiological examinations (neurophysiological examinations) Conduction, brain waves, sleep watch checks, etc.), brain injury biomarkers (Biomarker), healthy control group studies of host transcriptome",[13],[31],{"type":6,"name":32,"description":33,"armGroupLabels":34,"otherNames":10},"sequelae tracking","An integrated outpatient clinic for \"Long COVID-19 Syndrome in Children\" will be established to conduct systematic tracking of body, lung function, nerves and psychology. Children with neurological complications or other confirmed diagnoses will undergo physical, neurological, pulmonary function and brain MRI and neurophysiological examinations, sleep examinations, and conduct psychiatric clinical diagnostic interviews to establish a psychiatric diagnosis. Status and family social function, the intelligence development status was examined by intelligence test, and cognitive function was measured by neuropsychological test. Understand the microbial flora, immune function and incidence of allergic diseases after long-term COVID-19 infection",[9,15,19,27,23],[36],{"name":37,"affiliation":5,"role":38},"Luna-Yin Chang, professor","STUDY_CHAIR",[40],{"name":41,"role":42,"phone":43,"phoneExt":44,"email":45},"Tsui-Yien Fan, RA","CONTACT","+886 2312 3456","71730","twffccy@gmail.com",[47],{"facility":5,"status":48,"city":49,"state":50,"zip":51,"country":52,"countryCode":53,"cosmosGeoPoint":54,"geoPoint":59,"contacts":60},"RECRUITING","Taipei","Chung Cheng District","100","Taiwan","TW",{"type":55,"coordinates":56},"Point",[57,58],121.52639,25.05306,{"lat":58,"lon":57},[61],{"name":41,"role":42,"phone":43,"phoneExt":62,"email":45},"711730",{"type":64,"investigatorFullName":10,"investigatorTitle":10,"investigatorAffiliation":10,"oldNameTitle":10,"oldOrganization":10},"SPONSOR","100484013","clinical-characteristics-and-long-term-impact-on-pediatric-covid-19-in-taiwan-100484013",false,"NCT05582512","Clinical Characteristics and Long Term Impact on Pediatric COVID-19 in Taiwan","Inclusion Criteria:\n\n* COVID-19 positive cases\n\nExclusion Criteria:\n\n1. You have metal substances that cannot be removed or implanted, such as: braces, metal nails, artificial electronic ears, heartbeat pacemakers, etc. Because of the inability to perform brain MRI, it is not suitable to participate in this trial.\n2. Have major physical diseases.\n3. Sensory impairment, such as deafness.\n4. Movement disorders, such as cerebral palsy.\n5. Uncontrolled and stable epilepsy.\n6. Pregnant women are not suitable to participate in this test. (If you are pregnant or not sure if you are pregnant, please let the researcher know in advance so that a pregnancy test can be performed).\n7. Those who have suffered from hypoxia due to encephalitis or other reasons not caused by enterovirus infection are not suitable to participate in this test.",true,"ALL","18 Years",{"count":75,"type":76},3000,"ESTIMATED","1 Year","OBSERVATIONAL","This project will study severe COVID-19 related factors, host genes, biomarkers, and prognosis of severe encephalitis in children, and conduct:\n\n1. Retrospective clinical analysis of children with COVID-19, to analyze the clinical manifestations of children with new crown infection, and to find the relevant factors of severe disease.\n2. Prospective acceptance in the acute phase: mainly to understand the correlation between the interaction of host factors, viruses and microorganisms and the severity.\n3. Children's long COVID-19 Tracking Team An integrated outpatient clinic for \"Long COVID-19 Syndrome in Children\" will be established to conduct systematic tracking of body, lung function, nerves and psychology. Children with neurological complications or other confirmed diagnoses will undergo physical, neurological, pulmonary function and brain MRI and neurophysiological examinations, sleep examinations, and conduct psychiatric clinical diagnostic interviews to establish a psychiatric diagnosis. Status and family social function, the intelligence development status was examined by intelligence test, and cognitive function was measured by neuropsychological test. Understand the microbial phase, immune function and incidence of allergic diseases after long-term new coronavirus infection.\n4. Seroepidemiological Study Group Exploring the seroepidemiology of different groups of health care workers and non-health care workers will allow us to better understand the magnitude of natural infection among children and age groups in the community and the infection profile of health care workers during this period.\n\nThis trial includes multiple groups of prospective cases to explore the impact of the new coronavirus on children and the mechanism of severe illness, and integrates various specialties and branches of the Children's Hospital to conduct a summary trial, which is expected to understand children's new crown and community epidemiology, children infected with new crown Clinical manifestations of the virus, risk factors and effects on various systems, combined with host microbiome, immune function analysis and whole-exome sequencing, to improve the detection of new coronavirus (including long-term new coronary syndrome and pediatric multisystem inflammatory syndrome). Mechanisms of host factors and interactions with microbes to improve outcomes and severe incidence in children.",[81,82,83],"Long Covid19","COVID-19 Pneumonia","Multisystem Inflammatory Syndrome in Children",[85,86,87],"COVID-19","long COVID","MIS-C","2023-11-15",{"date":90,"type":91},"2023-11-18","ACTUAL",{"date":93,"type":91},"2022-07-01",{"date":95,"type":76},"2027-12",{"name":5,"class":6},1]