[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100604759":3},{"organization":4,"armGroups":7,"interventions":21,"overallOfficials":37,"centralContacts":42,"locations":51,"responsibleParty":69,"collaborators":27,"id":73,"slug":74,"hasResults":75,"nctId":76,"briefTitle":77,"officialTitle":78,"acronym":27,"eligibilityCriteria":79,"healthyVolunteers":75,"sex":80,"minAge":81,"maxAge":82,"enrollmentInfo":83,"targetDuration":27,"studyType":86,"phases":87,"briefSummary":89,"conditions":90,"keywords":93,"overallStatus":53,"whyStopped":27,"lastUpdateSubmitDate":98,"lastUpdatePostDateStruct":99,"startDateStruct":102,"completionDateStruct":104,"leadSponsor":106,"locationsCount":107},{"fullName":5,"class":6},"Second Affiliated Hospital, School of Medicine, Zhejiang University","OTHER",[8,15],{"label":9,"type":10,"description":11,"interventionNames":12},"real tDCS group","EXPERIMENTAL","tDCS Treatment Protocol The anode of the electrode pad will be placed on the swallowing sensorimotor cortex (S1\u002FM1). The cathode will be placed on the contralateral supraorbital margin. The S1\u002FM1 areas of the left and right hemispheres will be stimulated alternately, with a current intensity of 1.6mA. The treatment will be given once daily, 20 minutes per session, 5 times a week, for 2 consecutive weeks, totaling 10 sessions (5 sessions for each hemisphere).\n\nConventional Dysphagia Treatment\n\n1. Training for perioral muscles, tongue sensory and motor functions, including ice cotton swab stimulation, gustatory stimulation, tongue muscle movement training, etc.;\n2. Airway protection training, including Mendelsohn maneuver, supraglottic swallow training, etc.;",[13,14],"Device: tDCS","Behavioral: Conventional Dysphagia Treatment",{"label":16,"type":17,"description":18,"interventionNames":19},"sham tDCS group","SHAM_COMPARATOR","Sham tDCS Treatment Protocol The electrode positions and treatment frequency of sham tDCS will be the same as those of real tDCS. The current is 0.05 mA. The treatment will be given once daily, 20 minutes per session, 5 times a week, for 2 consecutive weeks, totaling 10 sessions (5 sessions for each hemisphere).\n\nConventional Dysphagia Treatment\n\n1. Training for perioral muscles, tongue sensory and motor functions, including ice cotton swab stimulation, gustatory stimulation, tongue muscle movement training, etc.;\n2. Airway protection training, including Mendelsohn maneuver, supraglottic swallow training, etc.;",[14,20],"Device: sham tDCS",[22,28,33],{"type":23,"name":24,"description":25,"armGroupLabels":26,"otherNames":27},"DEVICE","tDCS","The IS200 intelligent electrical stimulator, manufactured in Chengdu, Sichuan, will be used. The electrode pads are 4cm × 6cm in size. The anode of the electrode pad will be placed on the swallowing sensorimotor cortex (S1\u002FM1). The specific positioning will follow the international 10-20 electroencephalographic system: the left S1\u002FM1 area is located at the midpoint of the line connecting C3 and T3 in the left hemisphere; the right S1\u002FM1 area is located at the midpoint of the line connecting C4 and T4 in the right hemisphere. The cathode will be placed on the contralateral supraorbital margin. The S1\u002FM1 areas of the left and right hemispheres will be stimulated alternately, with a current intensity of 1.6mA. The treatment will be given once daily, 20 minutes per session, 5 times a week, for 2 consecutive weeks, totaling 10 sessions (5 sessions for each hemisphere).",[9],null,{"type":29,"name":30,"description":31,"armGroupLabels":32,"otherNames":27},"BEHAVIORAL","Conventional Dysphagia Treatment","1. Training for perioral muscles, tongue sensory and motor functions, including ice cotton swab stimulation, gustatory stimulation, tongue muscle movement training, etc.;\n2. Airway protection training, including Mendelsohn maneuver, supraglottic swallow training, etc.;",[9,16],{"type":23,"name":34,"description":35,"armGroupLabels":36,"otherNames":27},"sham tDCS","According to previous literature, the electrode positions and treatment frequency of sham tDCS will be the same as those of real tDCS. The current will be adjusted to 0.05mA.",[16],[38],{"name":39,"affiliation":40,"role":41},"Ping Wang","Second Affiliated Hospital of Zhejiang University School of Medicine","PRINCIPAL_INVESTIGATOR",[43,48],{"name":44,"role":45,"phone":46,"phoneExt":27,"email":47},"Ping Wang, MS","CONTACT","15158113194","wangping6288@zju.edu.cn",{"name":49,"role":45,"phone":27,"phoneExt":27,"email":50},"Bo Wang, MD","wangke1121@zju.edu.cn",[52],{"facility":40,"status":53,"city":54,"state":55,"zip":56,"country":57,"countryCode":58,"cosmosGeoPoint":59,"geoPoint":64,"contacts":65},"RECRUITING","Hangzhou","Zhejiang","310000","China","CN",{"type":60,"coordinates":61},"Point",[62,63],120.16142,30.29365,{"lat":63,"lon":62},[66,68],{"name":44,"role":45,"phone":46,"phoneExt":27,"email":67},"441350830@qq.com",{"name":49,"role":45,"phone":27,"phoneExt":27,"email":50},{"type":70,"investigatorFullName":71,"investigatorTitle":72,"investigatorAffiliation":5,"oldNameTitle":27,"oldOrganization":27},"SPONSOR_INVESTIGATOR","Wang Ping","senior therapist","100604759","clinical-efficacy-and-mechanism-of-tdcs-for-dysphagia-in-pd-100604759",false,"NCT07153692","Clinical Efficacy and Mechanism of tDCS for Dysphagia in PD","Clinical Efficacy and Mechanism of tDCS for Dysphagia in Patients With Parkinson's Disease","Inclusion Criteria:\n\n* Meet the Chinese Diagnostic Criteria for Parkinson's Disease (2016) or MDS Diagnostic Criteria for Multiple System Atrophy or Progressive Supranuclear Palsy;\n* VFSS examination indicates dysphagia;\n* Mini-Mental State Examination (MMSE) score \\>23;\n* Willing to cooperate with the study and sign the informed consent form;\n\nExclusion Criteria:\n\n* Comorbid with other diseases that cause dysphagia;\n* Comorbid with pneumonia, or severe cardiac\u002Frenal insufficiency;\n* Having metal implants in the body\n* With cognitive impairment or inability to cooperate.","ALL","18 Years","100 Years",{"count":84,"type":85},58,"ESTIMATED","INTERVENTIONAL",[88],"NA","This study aims to verify transcranial direct current stimulation(tDCS) efficacy for Parkinson's disease (PD)-related dysphagia and its mechanism. Subjects are randomly split into two groups: control (sham tDCS + conventional dysphagia treatment) and experimental (real tDCS + conventional treatment).\n\nAssessments will be conducted at baseline, after the completion of intervention, and at the 3-month follow-up. Swallowing function will be evaluated via gold-standard videofluoroscopic swallowing study (VFSS) and scales. Resting-state functional magnetic resonance imaging (rs-fMRI) or functional near-infrared spectroscopy (fNIRS) will be measures for tracking changes in abnormal brain regions\u002Fnetworks.\n\nCorrelations between swallowing recovery and brain function changes, plus group imaging differences, will reveal tDCS's neurophysiological mechanism.",[91,92],"Parkinson's Disease and Parkinsonism","Dysphagia",[94,95,96,24,97],"Parkinson's disease","Atypical Parkinsonian Syndromes","dysphagia","VFSS","2025-08-30",{"date":100,"type":101},"2025-09-04","ACTUAL",{"date":103,"type":101},"2025-07-17",{"date":105,"type":85},"2030-03-31",{"name":71,"class":6},1]