[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100584542":3},{"organization":4,"armGroups":7,"interventions":18,"overallOfficials":24,"centralContacts":28,"locations":37,"responsibleParty":63,"collaborators":10,"id":65,"slug":66,"hasResults":67,"nctId":68,"briefTitle":69,"officialTitle":70,"acronym":10,"eligibilityCriteria":71,"healthyVolunteers":72,"sex":73,"minAge":74,"maxAge":75,"enrollmentInfo":76,"targetDuration":10,"studyType":79,"phases":10,"briefSummary":80,"conditions":81,"keywords":10,"overallStatus":57,"whyStopped":10,"lastUpdateSubmitDate":84,"lastUpdatePostDateStruct":85,"startDateStruct":88,"completionDateStruct":90,"leadSponsor":92,"locationsCount":93},{"fullName":5,"class":6},"Tongji Hospital","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"ischemic cerebrovascular disease",null,"clinical diagnosis with ischemic cerebrovascular disease",[13],"Diagnostic Test: biomaker levels",{"label":15,"type":10,"description":16,"interventionNames":17},"health control","age- and sex-matched control individuals",[13],[19],{"type":20,"name":21,"description":22,"armGroupLabels":23,"otherNames":10},"DIAGNOSTIC_TEST","biomaker levels","this study will discover and validate novel biomarkers (including urine, feces, cerebrospinal fluid, blood, plaques, emboli, drainage fluid, bone marrow, lymph nodes and brain tissue etc al) of ischemic cerebrovascular disease",[15,9],[25],{"name":26,"affiliation":5,"role":27},"Dai-Shi Tian","PRINCIPAL_INVESTIGATOR",[29,34],{"name":30,"role":31,"phone":32,"phoneExt":10,"email":33},"Luo-Qi Zhou","CONTACT","86-27-83663337","zhouluoqi@tjh.tjmu.edu.cn",{"name":35,"role":31,"phone":32,"phoneExt":10,"email":36},"Xiaowei Pang","pangxiaowei1998@163.com",[38,56],{"facility":39,"status":40,"city":41,"state":42,"zip":43,"country":44,"countryCode":45,"cosmosGeoPoint":46,"geoPoint":51,"contacts":52},"Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology,","NOT_YET_RECRUITING","Wuhan","Hubei","430030","China","CN",{"type":47,"coordinates":48},"Point",[49,50],114.26667,30.58333,{"lat":50,"lon":49},[53],{"name":54,"role":31,"phone":32,"phoneExt":10,"email":55},"Daishi Tian","tiands@tjh.tjmu.edu.cn",{"facility":39,"status":57,"city":41,"state":42,"zip":43,"country":44,"countryCode":45,"cosmosGeoPoint":58,"geoPoint":60,"contacts":61},"RECRUITING",{"type":47,"coordinates":59},[49,50],{"lat":50,"lon":49},[62],{"name":54,"role":31,"phone":32,"phoneExt":10,"email":55},{"type":27,"investigatorFullName":54,"investigatorTitle":64,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"Prof.","100584542","clinical-evaluation-of-new-biomarkers-for-ischemic-cerebrovascular-disease-100584542",false,"NCT06890702","Clinical Evaluation of New Biomarkers for Ischemic Cerebrovascular Disease","A Prospective Observational Cohort Study of Predictive Biomarkers Related With Ischemic Cerebrovascular Disease","Inclusion Criteria:\n\n* Ischemic cerebrovascular disease has been proved by clinical symptoms and imaging examinations,including transient ischemic attack, cerebral ischemic stroke, steal syndrome, chronic cerebral hypoperfusion, ect al.\n* sex and age-matched healthy individuals\n\nExclusion Criteria:\n\n* Brain CT or MRI showing cerebral hemorrhage (excluded ischemic stroke with hemorrhage transformation)\n* With severe systemic disease, are expected to survive \\\u003C 3 months\n* Patients will not able to provide continuous follow-up information",true,"ALL","18 Years","90 Years",{"count":77,"type":78},7000,"ESTIMATED","OBSERVATIONAL","The goal of this single-center prospective observational study is to identify and evaluate new biomarkers for ischemic cerebrovascular disease (ICVD) to aid in early diagnosis, individualized treatment planning, and prognosis prediction in affected patients. The main questions it aims to answer are:\n\nCan specific biomarkers help in identifying high-risk individuals before disease onset? Can these biomarkers predict disease progression and treatment response? Researchers will compare patients diagnosed with ICVD and healthy controls from a medical check-up center to assess differences in biomarker expression and their clinical significance.\n\nParticipants will:\n\nProvide blood, cerebrospinal fluid, urine, and stool samples for biomarker analysis.\n\nUndergo clinical imaging (CT, MRI, PET-CT) and functional assessments. Be followed up at 3, 6, 12, 24, 36, and 48 months for clinical outcomes and biomarker changes.\n\nThis study aims to develop a comprehensive biomarker-based prediction model to enhance the diagnosis and management of ischemic cerebrovascular disease.",[82,83],"Ischemic Stroke","Ischemic Cerebrovascular Disease","2025-12-02",{"date":86,"type":87},"2025-12-09","ACTUAL",{"date":89,"type":87},"2025-01-01",{"date":91,"type":78},"2038-01-01",{"name":5,"class":6},2]