[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100553890":3},{"organization":4,"armGroups":7,"interventions":18,"overallOfficials":23,"centralContacts":28,"locations":33,"responsibleParty":55,"collaborators":10,"id":57,"slug":58,"hasResults":59,"nctId":60,"briefTitle":61,"officialTitle":62,"acronym":10,"eligibilityCriteria":63,"healthyVolunteers":59,"sex":64,"minAge":65,"maxAge":66,"enrollmentInfo":67,"targetDuration":10,"studyType":70,"phases":10,"briefSummary":71,"conditions":72,"keywords":10,"overallStatus":35,"whyStopped":10,"lastUpdateSubmitDate":80,"lastUpdatePostDateStruct":81,"startDateStruct":84,"completionDateStruct":86,"leadSponsor":88,"locationsCount":89},{"fullName":5,"class":6},"Sichuan Provincial People's Hospital","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"viral sepsis group",null,"The viral sepsis group comprises patients with sepsis secondary to viral infections, specifically COVID-19. Patients in this group were admitted to the ICU of Sichuan Provincial People's Hospital between July 2021 and December 2023 and diagnosed with viral sepsis based on positive RT-PCR results for SARS-CoV-2.",[13],"Other: observation",{"label":15,"type":10,"description":16,"interventionNames":17},"bacterial sepsis group","The bacterial sepsis group includes patients with sepsis resulting from bacterial infections. These patients were admitted to the ICU of Sichuan Provincial People's Hospital during the same period and diagnosed with bacterial sepsis based on positive bacterial cultures.",[13],[19],{"type":6,"name":20,"description":21,"armGroupLabels":22,"otherNames":10},"observation","data collected includes demographic information, clinical outcomes (mortality rate, ICU stay length), inflammatory markers (e.g., IL-2, IL-10, TNF-α), and treatment details (mechanical ventilation, CRRT, ECMO, antibiotics). Culture results, NGS findings, and imaging reports were also documented.",[15,9],[24],{"name":25,"affiliation":26,"role":27},"Lin Chen, doctor","Sichuan Provincial People's Hospita","PRINCIPAL_INVESTIGATOR",[29],{"name":25,"role":30,"phone":31,"phoneExt":10,"email":32},"CONTACT","8618111585286","chenlinhx@med.uestc.edu.cn",[34],{"facility":5,"status":35,"city":36,"state":37,"zip":38,"country":39,"countryCode":40,"cosmosGeoPoint":41,"geoPoint":46,"contacts":47},"RECRUITING","Chengdu","Sichuan","610091","China","CN",{"type":42,"coordinates":43},"Point",[44,45],104.06667,30.66667,{"lat":45,"lon":44},[48,51],{"name":49,"role":30,"phone":50,"phoneExt":10,"email":32},"Lin Chen","+8618111585286",{"name":52,"role":30,"phone":53,"phoneExt":10,"email":54},"Da Jing","+8613547136509","jingda1989@163.com",{"type":27,"investigatorFullName":49,"investigatorTitle":56,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"chief physician","100553890","clinical-outcomes-and-inflammatory-responses-in-viral-vs-bacterial-sepsis-100553890",false,"NCT06491966","Clinical Outcomes and Inflammatory Responses in Viral vs. Bacterial Sepsis","Comparative Analysis of Clinical Outcomes and Inflammatory Responses in Viral Versus Bacterial Sepsis: A Retrospective Cohort Study in ICU Patients","Inclusion Criteria:\n\n1. Patients diagnosed with sepsis according to Sepsis 3.0 criteria.\n2. Patients with confirmed bacterial sepsis based on positive bacterial cultures.\n3. Patients with confirmed viral sepsis, specifically COVID-19, diagnosed via RT-PCR for SARS-CoV-2 for viral group and negative for bacterial group.\n4. Patients aged 18 years and older.\n5. Patients admitted to the ICU during the study period.\n\nExclusion Criteria:\n\n1. Patients with mixed bacterial and viral infections.\n2. Patients with sepsis not meeting the Sepsis 3.0 criteria.\n3. Patients who received immunomodulatory therapies other than standard treatments (e.g., investigational drugs).\n4. Pregnant or breastfeeding women.","ALL","18 Years","90 Years",{"count":68,"type":69},300,"ESTIMATED","OBSERVATIONAL","This observational cohort study aims to compare clinical outcomes and inflammatory responses between patients with viral sepsis, specifically COVID-19-associated sepsis, and those with bacterial sepsis. Conducted at Sichuan Provincial People's Hospital, the study will retrospectively analyze data from ICU patients admitted between July 2021 and December 2023. The primary objective is to identify reliable biomarkers and diagnostic methods to improve patient outcomes through personalized diagnostic and therapeutic strategies.",[73,74,75,76,77,78,79],"Sepsis","Sepsis Bacterial","Viral Sepsis","Inflammatory Response","Cytokine Storm","COVID-19","MODS","2024-07-08",{"date":82,"type":83},"2024-07-09","ACTUAL",{"date":85,"type":83},"2024-04-02",{"date":87,"type":69},"2024-07-10",{"name":5,"class":6},1]