[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100642802":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":25,"centralContacts":25,"locations":25,"responsibleParty":30,"collaborators":25,"id":34,"slug":35,"hasResults":36,"nctId":37,"briefTitle":38,"officialTitle":39,"acronym":25,"eligibilityCriteria":40,"healthyVolunteers":36,"sex":41,"minAge":42,"maxAge":43,"enrollmentInfo":44,"targetDuration":25,"studyType":47,"phases":48,"briefSummary":50,"conditions":51,"keywords":55,"overallStatus":60,"whyStopped":25,"lastUpdateSubmitDate":61,"lastUpdatePostDateStruct":62,"startDateStruct":65,"completionDateStruct":67,"leadSponsor":69,"locationsCount":25},{"fullName":5,"class":6},"Cairo University","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Hybrid ceramic group","EXPERIMENTAL","indirect restoration (inlay design) using CAD\u002FCAM Fabricated Hard Hybrid Ceramic blocks",[13],"Other: hybrid ceramics",{"label":15,"type":16,"description":17,"interventionNames":18},"Composite Resin group","ACTIVE_COMPARATOR","indirect restoration (inlay design) using CAD\u002FCAM Fabricated from Composite Resin Blocks",[19],"Other: Composite resin",[21,26],{"type":6,"name":22,"description":23,"armGroupLabels":24,"otherNames":25},"hybrid ceramics","after caries removal, inlay cavity preparation and immediate dentin sealing, the cavities were scanned using intraoral scanner and the restoration designed and milled using Hard Hybrid Ceramic Blocks. the intaglio surface was air-abraded with 50 μm Al2O3 for 10-15 seconds. SHOFU HC Primer will be applied to the hybrid-ceramic group.",[9],null,{"type":6,"name":27,"description":28,"armGroupLabels":29,"otherNames":25},"Composite resin","after caries removal, inlay cavity preparation and immediate dentin sealing, the cavities were scanned using intraoral scanner and the restoration designed and milled using Composite Resin Blocks. the intaglio surface was air-abraded with 50 μm Al2O3 for 10-15 seconds.",[15],{"type":31,"investigatorFullName":32,"investigatorTitle":33,"investigatorAffiliation":5,"oldNameTitle":25,"oldOrganization":25},"PRINCIPAL_INVESTIGATOR","Sayed Ahmed Sayed Karim","PhD Student at Department of Conservative Dentistry","100642802","clinical-performance-of-cadcam-hard-hybrid-ceramic-inlays-versus-resin-composite-inlays-in-vital-molars-with-extensive-occluso-proximal-cavities-100642802",false,"NCT07648485","Clinical Performance of CAD\u002FCAM Hard Hybrid Ceramic Inlays Versus Resin Composite Inlays in Vital Molars With Extensive Occluso-Proximal Cavities","Clinical Performance of CAD\u002FCAM Hard Hybrid Ceramic Inlays Versus Resin Composite Inlays in Vital Molars With Extensive Occluso-Proximal Cavities: Two-Year Randomized Clinical Trial","Inclusion Criteria:\n\n* Systematically healthy male or female subjects aged 16 to 50 years.\n* Patients with good oral hygiene.\n* Presence of a single vital molar with coronal destruction due to caries, defined as radiographic evidence of caries involving more than 50% of the total dentin thickness with loss of at least one proximal wall.\n* Cavitary preparation involving loss of at least one proximal walls (mesial and\u002For distal), with intact buccal and lingual walls, and all cavosurface margins located in enamel.\n* Presence of functional opposing teeth in stable occlusion\n\nExclusion Criteria:\n\n* Presence of systemic diseases (e.g., uncontrolled diabetes, immune disorders).\n* Current pregnancy or lactation.\n* Documented allergy to resin-based composites or adhesive systems.\n* Evidence of pulpal necrosis or previous endodontic treatment in the target tooth.\n* Presence of cracks or fractures involving the tooth structure.\n* Active localized or generalized periodontal disease.\n* Evidence of parafunctional habits, including bruxism or clenching.\n* High caries risk.","ALL","16 Years","50 Years",{"count":45,"type":46},50,"ESTIMATED","INTERVENTIONAL",[49],"NA","this study aims to compare the clinical performance of hard hybrid ceramics and composite resin indirect restorations fabricated by CAD\u002FCAM technology for the vital teeth with occluso-proximal cavities. the clinical performance assessed include marginal adaptation primarily and in addition to Color match, marginal discoloration, aesthetic anatomic form, recurrent caries and restoration fracture and post-operative hypersensitivity. the clinical performance will be assessed after the restoration cementation, after 6, 12, 18 and 24 months.",[52,53,54],"Dental Caries","Cavity, Dental","Proximal Dental Caries",[56,57,58,59,22],"indirect restoration","CAD\u002FCAM","clinical performance","inlay","NOT_YET_RECRUITING","2026-06-13",{"date":63,"type":64},"2026-06-16","ACTUAL",{"date":66,"type":46},"2026-08",{"date":68,"type":46},"2028-11",{"name":5,"class":6}]