[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100455231":3},{"organization":4,"armGroups":7,"interventions":10,"overallOfficials":33,"centralContacts":38,"locations":48,"responsibleParty":63,"collaborators":10,"id":66,"slug":67,"hasResults":68,"nctId":69,"briefTitle":70,"officialTitle":70,"acronym":10,"eligibilityCriteria":71,"healthyVolunteers":68,"sex":72,"minAge":73,"maxAge":74,"enrollmentInfo":75,"targetDuration":10,"studyType":78,"phases":10,"briefSummary":79,"conditions":80,"keywords":83,"overallStatus":50,"whyStopped":10,"lastUpdateSubmitDate":89,"lastUpdatePostDateStruct":90,"startDateStruct":93,"completionDateStruct":95,"leadSponsor":97,"locationsCount":98},{"fullName":5,"class":6},"Peking University Third Hospital","OTHER",[8,12,15,18,21,24,27,30],{"label":9,"type":10,"description":11,"interventionNames":10},"0.5 h group",null,"Blood samples were taken 0.5 h after dexamethasone administration",{"label":13,"type":10,"description":14,"interventionNames":10},"2 h group","Blood samples were taken 2 h after dexamethasone administration",{"label":16,"type":10,"description":17,"interventionNames":10},"4 h group","Blood samples were taken 4 h after dexamethasone administration",{"label":19,"type":10,"description":20,"interventionNames":10},"6 h group","Blood samples were taken 6 h after dexamethasone administration",{"label":22,"type":10,"description":23,"interventionNames":10},"12 h group","Blood samples were taken 12 h after dexamethasone administration",{"label":25,"type":10,"description":26,"interventionNames":10},"24 h group","Blood samples were taken 24 h after dexamethasone administration",{"label":28,"type":10,"description":29,"interventionNames":10},"36 h group","Blood samples were taken 36 h after dexamethasone administration",{"label":31,"type":10,"description":32,"interventionNames":10},"48 h group","Blood samples were taken 48 h after dexamethasone administration",[34],{"name":35,"affiliation":36,"role":37},"Liu Dongyang","Drug Clinical Trial Center","PRINCIPAL_INVESTIGATOR",[39,44],{"name":40,"role":41,"phone":42,"phoneExt":10,"email":43},"Dongyang Liu","CONTACT","（86）010-82266658","liudongyang@vip.sina.com",{"name":45,"role":41,"phone":46,"phoneExt":10,"email":47},"Song Jie","86-17302556737","fssongjie@163.com",[49],{"facility":40,"status":50,"city":51,"state":10,"zip":52,"country":53,"countryCode":54,"cosmosGeoPoint":55,"geoPoint":60,"contacts":61},"RECRUITING","Beijing","100191","China","CN",{"type":56,"coordinates":57},"Point",[58,59],116.39723,39.9075,{"lat":59,"lon":58},[62],{"name":40,"role":41,"phone":10,"phoneExt":10,"email":43},{"type":64,"investigatorFullName":40,"investigatorTitle":65,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"SPONSOR_INVESTIGATOR","Vice director of Drug Clinical Trial Center","100455231","clinical-pharmacology-of-dexamethasone-in-pregnant-women-with-preterm-labor-100455231",false,"NCT05207852","Clinical Pharmacology of Dexamethasone in Pregnant Women With Preterm Labor","Inclusion Criteria:\n\n* Aged 20-40 (inclusive);\n* Body mass Index (BMI) 18.5-27.9kg \u002Fm2 (inclusive)\n* Single and twin pregnancy;\n* Premature delivery at 24-36 weeks;\n* No antibiotics, prebiotics or probiotics were used one month before feces collection (such as Bifidobacterium triplex live powder, Lactobacillus acidophilus tablet, compound Lactobacillus acidophilus tablet, Bacillus subtilis diplex live intestinal capsule, etc.);\n* Preeclampsia patients accounted for about 1\u002F10 of each group;\n* Use dexamethasone I.M. 5mg Q12h regimen (or other dexamethasone administration regimen) to promote fetal lung maturation.\n\nExclusion Criteria:\n\n* Ectopic pregnancy;\n* Suffering from diabetes, fetal distress, serious infectious diseases (such as sepsis, septic shock), fever;\n* Those who have taken glucocorticoid drugs within 2 weeks before joining the clinical trial;\n* Those who took clindamycin during the study period;\n* Congenital fetal malformation or fetal hypoxia in early pregnancy;\n* Convulsive patients;\n* HIV\u002FHCV\u002F HEPATITIS A, drug abuse history;\n* Suffering from chorioamnitis, endometritis;\n* Placental abruption, severe intrauterine bleeding;\n* Pregnant women whose cervical dilation is greater than or equal to 4 cm or whose cervical length is less than or equal to 20 mm by ultrasound examination;\n* Pregnant women who took food or drugs during the study that might affect the safety of the fetus;\n* Pregnant women participating in other clinical trials.","FEMALE","20 Years","40 Years",{"count":76,"type":77},288,"ESTIMATED","OBSERVATIONAL","This study through to the pregnant woman blood concentrations of dexamethasone therapy after research, explore the pharmacokinetic data of dexamethasone in pregnant women, Chinese pregnant women dexamethasone pharmacokinetic model, provide a reference for the clinical use of dexamethasone dose, through the biomarkers of dexamethasone to promote fetal lung maturity and other metabolomics, It provides the basis for the effectiveness and safety study of dexamethasone.",[81,82],"Respiratory Distress Syndrome of Newborn","Threatened Premature Labor, Antepartum",[84,85,86,87,88],"Dexamethasone","Pregnancy","Preterm","Quantitative pharmacology","P-glycoprotein","2022-01-24",{"date":91,"type":92},"2022-01-26","ACTUAL",{"date":94,"type":92},"2021-12-01",{"date":96,"type":77},"2027-12-31",{"name":40,"class":6},1]