[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100588949":3},{"organization":4,"armGroups":7,"interventions":24,"overallOfficials":23,"centralContacts":33,"locations":39,"responsibleParty":56,"collaborators":58,"id":62,"slug":63,"hasResults":64,"nctId":65,"briefTitle":66,"officialTitle":66,"acronym":67,"eligibilityCriteria":68,"healthyVolunteers":64,"sex":69,"minAge":70,"maxAge":23,"enrollmentInfo":71,"targetDuration":23,"studyType":74,"phases":75,"briefSummary":77,"conditions":78,"keywords":81,"overallStatus":41,"whyStopped":23,"lastUpdateSubmitDate":85,"lastUpdatePostDateStruct":86,"startDateStruct":89,"completionDateStruct":91,"leadSponsor":93,"locationsCount":94},{"fullName":5,"class":6},"Brown University","OTHER",[8,14,19],{"label":9,"type":10,"description":11,"interventionNames":12},"Electronic Cigarette (EC) Condition","EXPERIMENTAL","Participants in this condition will receive the EC intervention.",[13],"Other: Electronic Cigarettes (EC)",{"label":15,"type":10,"description":16,"interventionNames":17},"Nicotine Replacement Therapy Condition","Participants in this condition will receive the NRT intervention.",[18],"Other: Nicotine replacement therapy (NRT)",{"label":20,"type":21,"description":22,"interventionNames":23},"No-Product Control Condition (CON)","NO_INTERVENTION","Participants in this condition will not receive any alternate nicotine product.",null,[25,29],{"type":6,"name":26,"description":27,"armGroupLabels":28,"otherNames":23},"Electronic Cigarettes (EC)","Participants will receive information about the comparative risk of alternative nicotine products relative to smoking and will be asked to switch to EC for 8 weeks, with EC provided.",[9],{"type":6,"name":30,"description":31,"armGroupLabels":32,"otherNames":23},"Nicotine replacement therapy (NRT)","Participants will receive information about the comparative risk of alternative nicotine products relative to smoking and will be asked to switch to combination NRT (transdermal + oral) for 8 weeks, with NRT provided.",[15],[34],{"name":35,"role":36,"phone":37,"phoneExt":23,"email":38},"CRESCENT Study Research Staff","CONTACT","401-203-5339","CRESCENT@brown.edu",[40],{"facility":5,"status":41,"city":42,"state":43,"zip":44,"country":45,"countryCode":46,"cosmosGeoPoint":47,"geoPoint":52,"contacts":53},"RECRUITING","Providence","Rhode Island","02912","United States","US",{"type":48,"coordinates":49},"Point",[50,51],-71.41283,41.82399,{"lat":51,"lon":50},[54],{"name":55,"role":36,"phone":37,"phoneExt":23,"email":38},"CRESCENT Research Staff",{"type":57,"investigatorFullName":23,"investigatorTitle":23,"investigatorAffiliation":23,"oldNameTitle":23,"oldOrganization":23},"SPONSOR",[59],{"name":60,"class":61},"National Institute of General Medical Sciences (NIGMS)","NIH","100588949","clinical-research-evaluating-smoking-cessation-with-e-cigarettes-and-nicotine-therapy-100588949",false,"NCT06948058","Clinical Research Evaluating Smoking Cessation With E-Cigarettes and Nicotine Therapy","CRESCENT","Inclusion Criteria:\n\n* body mass index (BMI) ≥ 30 kg\u002Fm2 (i.e., obese)\n* smoked ≥ 5 cigarettes\u002Fday during the past year\n* 21 or older (due to minimum legal age EC restrictions)\n* exhaled breath carbon monoxide (CO) level \\> 6 ppm at Baseline (BL) (to confirm self-reported smoking)\n* willing to use EC or NRT for 8 weeks\n* access to a Bluetooth-enabled smartphone\u002Ftablet (to permit remote measurement of CO and other outcome variables)\n\nExclusion Criteria:\n\n* received smoking cessation treatment of any kind in the past 30 days (actively quitting smoking),\n* currently using EC or NRT more than 2 days\u002Fweek (this may affect responses to study-supplied products)\n* hospitalized for mental illness in past 30 days\n* heart-related event (e.g., heart attack, severe angina) in past 30 days\n* residing with another person currently enrolled in the study\n* pregnant, nursing, or planning to become pregnant in the next 6 months\n* medical contraindication for study or product use (e.g., allergy to adhesives)\n* taken prescription weight loss medication in the last 30 days","ALL","21 Years",{"count":72,"type":73},60,"ESTIMATED","INTERVENTIONAL",[76],"NA","This project will investigate the effects of alternative nicotine products on smoking, weight gain, and related outcomes.",[79,80],"Smoking Cessation","Obesity and Obesity-related Medical Conditions",[82,83,84],"obesity","electronic cigarettes","harm reduction","2026-05-14",{"date":87,"type":88},"2026-05-18","ACTUAL",{"date":90,"type":88},"2025-04-01",{"date":92,"type":73},"2027-08-31",{"name":5,"class":6},1]