[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100537116":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":25,"centralContacts":35,"locations":44,"responsibleParty":150,"collaborators":152,"id":167,"slug":168,"hasResults":169,"nctId":170,"briefTitle":171,"officialTitle":171,"acronym":24,"eligibilityCriteria":172,"healthyVolunteers":169,"sex":173,"minAge":174,"maxAge":24,"enrollmentInfo":175,"targetDuration":24,"studyType":178,"phases":179,"briefSummary":181,"conditions":182,"keywords":24,"overallStatus":47,"whyStopped":24,"lastUpdateSubmitDate":184,"lastUpdatePostDateStruct":185,"startDateStruct":188,"completionDateStruct":190,"leadSponsor":192,"locationsCount":193},{"fullName":5,"class":6},"Nordlandssykehuset HF","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"60-65 E% Carbohydrates","EXPERIMENTAL","Diet plan A with 60-65 E% Carbohydrates in 4 weeks",[13],"Other: Carbohydrates",{"label":15,"type":16,"description":17,"interventionNames":18},"40-45% Carbohydrates","ACTIVE_COMPARATOR","Diet plan B with 40-45 E% Carbohydrates in 4 weeks",[13],[20],{"type":6,"name":21,"description":22,"armGroupLabels":23,"otherNames":24},"Carbohydrates","Half of the patients will initially follow Diet Plan A with 60-65 E% carbohydrates for 4 weeks, followed by a 4-week washout period, and then Diet Plan B with 40-45 E% carbohydrates for 4 weeks. The other half will start with Diet Plan B for 4 weeks, followed by a 4-week washout period, and then Diet Plan A for 4 weeks . Diet Plans A and B contain recommended and adequate nutrients according to the Nordic Nutrition Recommendations 2023 (NNR2023) for maintaining a stable weight.",[15,9],null,[26,29,32],{"name":27,"affiliation":5,"role":28},"Elin Storjord, MD PhD","PRINCIPAL_INVESTIGATOR",{"name":30,"affiliation":31,"role":28},"Per Dahlqvist, MD PhD","Norrland University Hospital, Umeå",{"name":33,"affiliation":34,"role":28},"Eliane Sardh, MD PhD","Studieenheten, Akademiskt Specialistcentrum, Stockholm Läns Sjukvårdsområde, Region Stockholm",[36,40],{"name":27,"role":37,"phone":38,"phoneExt":24,"email":39},"CONTACT","97072484","elin.storjord@nordlandssykehuset.no",{"name":41,"role":37,"phone":42,"phoneExt":24,"email":43},"Hilde Thunhaug, Nurse","95057864","hilde.thunhaug@nordlandssykehuset.no",[45,113,133],{"facility":46,"status":47,"city":48,"state":49,"zip":50,"country":51,"countryCode":52,"cosmosGeoPoint":53,"geoPoint":58,"contacts":59},"Nordland Hospital Trust","RECRUITING","Bodø","Nordland","8092","Norway","NO",{"type":54,"coordinates":55},"Point",[56,57],14.37513,67.28267,{"lat":57,"lon":56},[60,62,65,66,69,71,73,75,77,79,81,83,85,87,89,91,93,95,97,99,101,103,105,107,109,111],{"name":27,"role":37,"phone":61,"phoneExt":24,"email":39},"+4797072484",{"name":63,"role":37,"phone":64,"phoneExt":24,"email":43},"Hilde Thunhaug, IC nurse","+47 95057864",{"name":27,"role":28,"phone":24,"phoneExt":24,"email":24},{"name":67,"role":68,"phone":24,"phoneExt":24,"email":24},"Amy Dickey, MD","SUB_INVESTIGATOR",{"name":70,"role":68,"phone":24,"phoneExt":24,"email":24},"Bjørn Steen Skålhegg, PhD, Prof.",{"name":72,"role":68,"phone":24,"phoneExt":24,"email":24},"Bård O. Karlsen, PhD",{"name":74,"role":68,"phone":24,"phoneExt":24,"email":24},"Elin Røst, Master",{"name":76,"role":68,"phone":24,"phoneExt":24,"email":24},"Erik Knutsen, PhD",{"name":78,"role":68,"phone":24,"phoneExt":24,"email":24},"Hilde Thunhaug, Bachelor",{"name":80,"role":68,"phone":24,"phoneExt":24,"email":24},"Jonas Aakre Wik, PhD",{"name":82,"role":68,"phone":24,"phoneExt":24,"email":24},"Andersen Karl, MD, Prof.",{"name":84,"role":68,"phone":24,"phoneExt":24,"email":24},"Pettersen Kristin, Bachelor",{"name":86,"role":68,"phone":24,"phoneExt":24,"email":24},"Marlene B. Karlsen, Master",{"name":88,"role":68,"phone":24,"phoneExt":24,"email":24},"Nina Lorentsen, Master",{"name":90,"role":68,"phone":24,"phoneExt":24,"email":24},"Ole-Lars Brekke, MD,PhD,Prof",{"name":92,"role":68,"phone":24,"phoneExt":24,"email":24},"Randolf Hardersen, MD, PhD",{"name":94,"role":68,"phone":24,"phoneExt":24,"email":24},"Rita Laastad, Bachelor",{"name":96,"role":68,"phone":24,"phoneExt":24,"email":24},"Steinar Daae Johansen, PhD, Dean",{"name":98,"role":68,"phone":24,"phoneExt":24,"email":24},"Tor Erik Jørgensen, PhD",{"name":100,"role":68,"phone":24,"phoneExt":24,"email":24},"Vegar Rangul, PhD",{"name":102,"role":68,"phone":24,"phoneExt":24,"email":24},"Åse Emblem, PhD",{"name":104,"role":68,"phone":24,"phoneExt":24,"email":24},"Fredrik Ellefsrud, MD",{"name":106,"role":68,"phone":24,"phoneExt":24,"email":24},"Tor Claudi, MD",{"name":108,"role":68,"phone":24,"phoneExt":24,"email":24},"Ingrid Joakimsen, Master",{"name":110,"role":68,"phone":24,"phoneExt":24,"email":24},"Trine Hauglid Aardalsbakke, Master",{"name":112,"role":68,"phone":24,"phoneExt":24,"email":24},"Guillaume Lemetais, PhD",{"facility":114,"status":47,"city":115,"state":24,"zip":24,"country":116,"countryCode":117,"cosmosGeoPoint":118,"geoPoint":122,"contacts":123},"Studieenheten, Akademiskt Specialistcentrum, Stockholm läns sjukvårdsområde, Region Stockholm","Stockholm","Sweden","SE",{"type":54,"coordinates":119},[120,121],18.06871,59.32938,{"lat":121,"lon":120},[124,128,132],{"name":33,"role":37,"phone":125,"phoneExt":126,"email":127},"(0)70 003 98 78","+46","eliane.sardh@regionstockholm.se",{"name":129,"role":37,"phone":130,"phoneExt":126,"email":131},"Lina Lundén-Bengtsberg, Master","(0)8-123 498 48","lina.lunden-bengtsberg@regionstockholm.se",{"name":33,"role":28,"phone":24,"phoneExt":24,"email":24},{"facility":134,"status":47,"city":135,"state":24,"zip":24,"country":116,"countryCode":117,"cosmosGeoPoint":136,"geoPoint":140,"contacts":141},"Norrland University Hospital","Umeå",{"type":54,"coordinates":137},[138,139],20.25972,63.82842,{"lat":139,"lon":138},[142,145,149],{"name":30,"role":37,"phone":143,"phoneExt":126,"email":144},"90-785 3390","per.dahlqvist@umu.se",{"name":146,"role":37,"phone":147,"phoneExt":126,"email":148},"Inger Arnesjø, Bachelor","907854391","inger.arnesjo@umu.se",{"name":30,"role":28,"phone":24,"phoneExt":24,"email":24},{"type":151,"investigatorFullName":24,"investigatorTitle":24,"investigatorAffiliation":24,"oldNameTitle":24,"oldOrganization":24},"SPONSOR",[153,155,157,159,161,163,165],{"name":154,"class":6},"University of Oslo",{"name":156,"class":6},"Nord University",{"name":158,"class":6},"UiT The Arctic University of Norway",{"name":160,"class":6},"Norwegian University of Science and Technology",{"name":162,"class":6},"The University of Texas Medical Branch, Galveston",{"name":164,"class":6},"Karolinska University Hospital",{"name":166,"class":6},"University Hospital, Umeå","100537116","clinical-research-on-acute-intermittent-porphyria-and-the-use-of-carbohydrate-rich-diet-as-a-treatment-100537116",false,"NCT06273644","Clinical Research on Acute Intermittent Porphyria and the Use of Carbohydrate-Rich Diet as a Treatment","Inclusion Criteria:\n\n* Diagnosis of AIP\n\nExclusion Criteria:\n\n* Not having diagnosis of AIP\n* Undergoing treatment as part of other clinical research on AIP\n* Pregnancy\n* Diabetes\n* Below 18 years of age","ALL","18 Years",{"count":176,"type":177},50,"ESTIMATED","INTERVENTIONAL",[180],"NA","The main aim of this clinical trial is to learn about the effect of carbohydrate-rich diet as a treatment for AIP (acute intermittent porphyria).\n\nAim: Investigate the diet's impact on tissue and serum glucose, plasma insulin, cytokine levels, amino acids, and gut microbiota in AIP, and their correlation with PBG (Porphobilinogen).\n\nAim: Assess the diet's effect on AIP symptoms and health status in AIP. Aim: Measure the effect of a high-carbohydrate diet on mitochondrial activity in AIP Aim: Map and detect potential mutations in mitochondrial genomic DNA in AIP Aim: Discover new markers in AIP through RNA sequencing and machine learning.\n\nParticipants will follow two diet plans, a 4-week intervention with 60-65 E% carbohydrates and a 4 week intervention with 40-45 E% carbohydrates.",[183],"Porphyria, Acute Intermittent","2026-03-25",{"date":186,"type":187},"2026-03-27","ACTUAL",{"date":189,"type":187},"2024-01-27",{"date":191,"type":177},"2037-12-31",{"name":5,"class":6},3]