[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100643642":3},{"organization":4,"armGroups":7,"interventions":24,"overallOfficials":42,"centralContacts":42,"locations":43,"responsibleParty":63,"collaborators":42,"id":67,"slug":68,"hasResults":69,"nctId":70,"briefTitle":71,"officialTitle":72,"acronym":42,"eligibilityCriteria":73,"healthyVolunteers":69,"sex":74,"minAge":75,"maxAge":42,"enrollmentInfo":76,"targetDuration":42,"studyType":79,"phases":80,"briefSummary":82,"conditions":83,"keywords":89,"overallStatus":45,"whyStopped":42,"lastUpdateSubmitDate":91,"lastUpdatePostDateStruct":92,"startDateStruct":95,"completionDateStruct":97,"leadSponsor":99,"locationsCount":100},{"fullName":5,"class":6},"Peking University People's Hospital","OTHER",[8,14,19],{"label":9,"type":10,"description":11,"interventionNames":12},"Lobectomy Group","EXPERIMENTAL","Patients receive standard lobectomy plus mediastinal lymph node sampling for early-stage non-small cell lung cancer, for elderly patients ≥65 years with T1N0M0 tumor. Postoperative standard perioperative management and regular follow-up are conducted.",[13],"Procedure: Pulmonary Lobectomy plus Mediastinal Lymph Node Sampling",{"label":15,"type":10,"description":16,"interventionNames":17},"Segmentectomy Group","Patients receive anatomic segmentectomy plus mediastinal lymph node sampling. All enrolled elderly patients are stratified by tumor size and preoperative geriatric risk score before randomization, followed by unified postoperative monitoring and adaptive perioperative treatment based on MRD and biomarker results.",[18],"Procedure: Pulmonary Segmentectomy plus Mediastinal Lymph Node Sampling",{"label":20,"type":10,"description":21,"interventionNames":22},"Wedge Resection Group","Patients receive pulmonary wedge resection plus mediastinal lymph node sampling. After surgery, low-risk patients get de-escalated adaptive perioperative treatment guided by postoperative MRD surveillance, while high-risk patients receive individualized intensive comprehensive therapy.",[23],"Procedure: Pulmonary Wedge Resection plus Mediastinal Lymph Node Sampling",[25,32,38],{"type":26,"name":27,"description":28,"armGroupLabels":29,"otherNames":30},"PROCEDURE","Pulmonary Lobectomy plus Mediastinal Lymph Node Sampling","Standard anatomical lobectomy combined with systematic mediastinal lymph node sampling for early-stage T1N0M0 non-small cell lung cancer in patients aged ≥65 years; postoperative stratified adaptive perioperative management guided by MRD and tumor biomarkers.",[9],[31],"Standard Radical Lung Resection",{"type":26,"name":33,"description":34,"armGroupLabels":35,"otherNames":36},"Pulmonary Segmentectomy plus Mediastinal Lymph Node Sampling","Curative segmentectomy with mediastinal lymph node sampling after preoperative comprehensive geriatric risk assessment (CGA, VES-13, ASA grading); postoperative personalized perioperative treatment stratified by postoperative minimal residual disease status.",[15],[37],"Anatomic Sublobar Resection",{"type":26,"name":39,"description":40,"armGroupLabels":41,"otherNames":42},"Pulmonary Wedge Resection plus Mediastinal Lymph Node Sampling","Wedge resection plus mediastinal lymph node sampling for eligible elderly early lung cancer patients; low-risk subjects receive de-escalated adaptive perioperative treatment, while high-risk patients receive intensified comprehensive therapy based on postoperative risk stratification.",[20],null,[44],{"facility":5,"status":45,"city":46,"state":47,"zip":48,"country":49,"countryCode":50,"cosmosGeoPoint":51,"geoPoint":56,"contacts":57},"RECRUITING","Beijing","Beijing Municipality","100044","China","CN",{"type":52,"coordinates":53},"Point",[54,55],116.39723,39.9075,{"lat":55,"lon":54},[58],{"name":59,"role":60,"phone":61,"phoneExt":42,"email":62},"Fan Yang, MD","CONTACT","010-88326650","2311210336@pku.edu.cn",{"type":64,"investigatorFullName":65,"investigatorTitle":66,"investigatorAffiliation":5,"oldNameTitle":42,"oldOrganization":42},"PRINCIPAL_INVESTIGATOR","Yang Fan, MD","Professor, Chief Physician","100643642","clinical-study-of-a-new-treatment-model-for-elderly-lung-cancer-patients-100643642",false,"NCT07632664","Clinical Study of a New Treatment Model for Elderly Lung Cancer Patients","A Multicenter Clinical Study on a New Treatment Model Combining New Surgical Techniques, Perioperative Comprehensive Treatment, and Postoperative Rehabilitation for Elderly Patients With Lung Cancer","Inclusion Criteria:\n\n1. Aged ≥65 years old\n2. Pathologically confirmed non-small cell lung cancer with clinical stage eligible for curative surgical resection\n3. Complete preoperative geriatric comprehensive assessment data available\n4. Capable of finishing planned surgery and long-term follow-up\n5. Voluntarily sign informed consent form\n\nExclusion Criteria:\n\n1. History of other malignant tumors within recent 5 years\n2. Severe organic dysfunction of heart, liver, renal or respiratory system that cannot tolerate thoracic surgery\n3. Preoperative confirmed distant metastasis preventing radical resection\n4. Uncontrolled active severe infection or obvious coagulation disorders\n5. Severe psychiatric disorder or cognitive dysfunction failing to cooperate with treatment and follow-up\n6. Refuse random grouping and postoperative regular monitoring","ALL","65 Years",{"count":77,"type":78},1000,"ESTIMATED","INTERVENTIONAL",[81],"NA","This multicenter prospective clinical study focuses on elderly patients with lung cancer. We will build a standardized clinical registry database, develop perioperative risk stratification and surgical early-warning models, optimize individualized surgical regimens, construct multidisciplinary perioperative comprehensive therapy, integrated Chinese-Western medicine full-cycle management and personalized postoperative rehabilitation systems, so as to form a whole-process optimized treatment model for elderly lung cancer.",[84,85,86,87,88],"Lung Neoplasm","Thoracic Surgical Procedures","Perioperative Care","Postoperative Rehabilitation","Aged",[90],"Elderly lung cancer, Risk stratification, Multimodality therapy, Integrated Chinese and Western Medicine, Enhanced recovery after surgery","2026-06-02",{"date":93,"type":94},"2026-06-08","ACTUAL",{"date":96,"type":94},"2024-08-01",{"date":98,"type":78},"2028-08-31",{"name":5,"class":6},1]