[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100637686":3},{"organization":4,"armGroups":7,"interventions":13,"overallOfficials":18,"centralContacts":22,"locations":10,"responsibleParty":27,"collaborators":10,"id":29,"slug":30,"hasResults":31,"nctId":32,"briefTitle":33,"officialTitle":34,"acronym":10,"eligibilityCriteria":35,"healthyVolunteers":31,"sex":36,"minAge":37,"maxAge":38,"enrollmentInfo":39,"targetDuration":10,"studyType":42,"phases":43,"briefSummary":45,"conditions":46,"keywords":49,"overallStatus":53,"whyStopped":10,"lastUpdateSubmitDate":54,"lastUpdatePostDateStruct":55,"startDateStruct":58,"completionDateStruct":60,"leadSponsor":62,"locationsCount":10},{"fullName":5,"class":6},"The First Affiliated Hospital of Xinxiang Medical College","OTHER",[8],{"label":9,"type":6,"description":10,"interventionNames":11},"subgingival scaling",null,[12],"Other: treatment group",[14],{"type":6,"name":15,"description":16,"armGroupLabels":17,"otherNames":10},"treatment group","subgingival scaling + BMP-2 hydrogel",[9],[19],{"name":20,"affiliation":5,"role":21},"Wenjie Ren","PRINCIPAL_INVESTIGATOR",[23],{"name":20,"role":24,"phone":25,"phoneExt":10,"email":26},"CONTACT","8613937354075","13937354075@163.com",{"type":28,"investigatorFullName":10,"investigatorTitle":10,"investigatorAffiliation":10,"oldNameTitle":10,"oldOrganization":10},"SPONSOR","100637686","clinical-study-of-bmp-2-injectable-hydrogel-for-promoting-alveolar-bone-regeneration-100637686",false,"NCT07611617","Clinical Study of BMP-2 Injectable Hydrogel for Promoting Alveolar Bone Regeneration","Study on Injectable Hydrogel Loaded With BMP-2 for Promoting Alveolar Bone Regeneration Induced by Periodontitis","Inclusion Criteria:\n\n* Clinical Diagnosis: Meets the 2018 International Classification of Periodontal Diseases, diagnosed with Stage III or IV periodontitis.\n* Bone Defect Characteristics: At least one affected tooth presents with a deep periodontal pocket (PPD ≥5 mm), and CBCT imaging confirms the presence of significant vertical bone resorption or angular bone defects (these defect types are most suitable for in-situ hydrogel filling and guided regeneration).\n* Age and General Condition: Aged between 18 and 70 years, any gender, generally in good systemic health.\n* Compliance and Consent: The subject is able to understand the study procedures, voluntarily sign the informed consent form, and commit to returning for follow-up visits as required (1, 3, 6, 12 months).\n\nExclusion Criteria:\n\n* Systemic Interference with Bone Metabolism: Presence of poorly controlled diabetes (HbA1c \\> 7%), osteoporosis, or long-term use of medications affecting bone metabolism such as bisphosphonates or glucocorticoids within the past six months.\n* Local Anatomical Limitations: The affected tooth has a vertical root fracture, severe periapical pathology, or a residual root that is deemed non-restorable and without preservation value.\n* Factors Interfering with Healing: Heavy smokers (average \\> 10 cigarettes per day), as impaired microcirculation can significantly compromise the biological effects of the hydrogel.\n* Special Physiological Periods: Pregnant or breastfeeding women.","ALL","18 Years","70 Years",{"count":40,"type":41},80,"ESTIMATED","INTERVENTIONAL",[44],"NA","This project aims to construct an injectable self-healing hydrogel loaded with BMP-2, with optimized gelation time and mechanical strength to meet the requirements for periodontal pocket filling, for the treatment of periodontitis and acceleration of tissue repair, achieving a \"bactericidal-anti-inflammatory-regenerative\" trinity function. This project will provide a novel intelligent material for promoting alveolar bone regeneration in periodontitis and establish a theoretical paradigm for the precise intervention of oral infectious diseases.",[47,48],"Periodontitis","Alveolar Bone Loss* \u002F Therapy",[47,50,51,52],"Alveolar Bone Loss* \u002F therapy","BMP-2","Hydrogel","NOT_YET_RECRUITING","2026-05-20",{"date":56,"type":57},"2026-05-28","ACTUAL",{"date":59,"type":41},"2026-05-01",{"date":61,"type":41},"2028-12-31",{"name":5,"class":6}]