[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100567446":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":31,"centralContacts":36,"locations":26,"responsibleParty":45,"collaborators":26,"id":47,"slug":48,"hasResults":49,"nctId":50,"briefTitle":51,"officialTitle":51,"acronym":26,"eligibilityCriteria":52,"healthyVolunteers":53,"sex":54,"minAge":55,"maxAge":26,"enrollmentInfo":56,"targetDuration":26,"studyType":59,"phases":60,"briefSummary":62,"conditions":63,"keywords":65,"overallStatus":69,"whyStopped":26,"lastUpdateSubmitDate":70,"lastUpdatePostDateStruct":71,"startDateStruct":74,"completionDateStruct":76,"leadSponsor":78,"locationsCount":26},{"fullName":5,"class":6},"Henan Provincial People's Hospital","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Oliceridine group","EXPERIMENTAL","Oliceridine 0.4mg · kg-1+tropisetron 10mg, mixed with physiological saline to 100ml. PCIA is set to continuous infusion of 2ml\u002Fh, with a single dose of 2ml and a locking time of 15 minutes.",[13],"Drug: Oliceridine",{"label":15,"type":16,"description":17,"interventionNames":18},"Sufentanil group","ACTIVE_COMPARATOR","Sufentanil 2 µ g · kg-1+tropisetron 10mg, mixed with physiological saline to 100ml. PCIA is set to continuous infusion of 2ml\u002Fh, with a single dose of 2ml and a locking time of 15 minutes.",[19],"Drug: Sulfentanil",[21,27],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"DRUG","Oliceridine","The formula for postoperative analgesia pump is oliceridine 0.4mg · kg-1+tropisetron 10mg, mixed with physiological saline to 100ml.",[9],null,{"type":22,"name":28,"description":29,"armGroupLabels":30,"otherNames":26},"Sulfentanil","The analgesic regimen for the sufentanil group is sufentanil 2 µ g · kg-1+tropisetron 10mg, mixed with physiological saline to 100ml.",[15],[32],{"name":33,"affiliation":34,"role":35},"Jiaqiang Zhang","Chief physician","STUDY_DIRECTOR",[37,42],{"name":38,"role":39,"phone":40,"phoneExt":26,"email":41},"Ningning Fu","CONTACT","8618790658707","736508728@qq.com",{"name":33,"role":39,"phone":43,"phoneExt":26,"email":44},"8613937121360","Jiaqiang197628@163.com",{"type":46,"investigatorFullName":26,"investigatorTitle":26,"investigatorAffiliation":26,"oldNameTitle":26,"oldOrganization":26},"SPONSOR","100567446","clinical-study-of-g-protein-biased----opioid-receptor-agonist-oliceridine-for-optimizing-postoperative-analgesia-under-general-anesthesia-100567446",false,"NCT06668298","Clinical Study of G Protein Biased Μ - Opioid Receptor Agonist Oliceridine for Optimizing Postoperative Analgesia Under General Anesthesia","Inclusion Criteria:\n\n1. Age\\>65 years old\n2. ASA Level I-III\n3. BMI 18.5-29.9\n4. Patients undergoing knee joint surface replacement surgery under general anesthesia\n5. Postoperative Patient Controlled Intravenous Analgesia Pump (PCIA) Treatment\n6. Possess reading and writing abilities\n7. You can sign an informed consent form\n\nExclusion Criteria:\n\n1. Suffering from chronic pain or mental illness before surgery\n2. Unable to communicate due to cognitive impairment or language barriers before surgery\n3. Patients who have used opioid drugs three days before surgery\n4. Patients with long-term alcohol consumption\n5. Abnormal liver and kidney function or dialysis patients\n6. Concurrent severe cardiovascular, respiratory, and autonomic neuropathy\n7. Participated in clinical studies of other drugs or medical devices in the past 3 months",true,"ALL","65 Years",{"count":57,"type":58},150,"ESTIMATED","INTERVENTIONAL",[61],"NA","Traditional opioid analgesia is a treatment method for moderate to severe pain. However, the use of opioid drugs is not without risks. When treating acute pain, patients may experience hypotension, respiratory depression, hypoxia, nausea and vomiting, irritability, and itching. The purpose of this study is to evaluate the comparison of G protein biased μ - opioid receptor agonist oliceridine and traditional μ - opioid receptor agonist sufentanil in terms of analgesia in patients under general anesthesia.",[64],"Old Age",[66,67,68],"old age","knee arthroplasty","pain","NOT_YET_RECRUITING","2024-10-30",{"date":72,"type":73},"2024-10-31","ACTUAL",{"date":75,"type":58},"2024-11",{"date":77,"type":58},"2025-06",{"name":5,"class":6}]