[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100629696":3},{"organization":4,"armGroups":7,"interventions":18,"overallOfficials":24,"centralContacts":29,"locations":35,"responsibleParty":52,"collaborators":10,"id":56,"slug":57,"hasResults":58,"nctId":59,"briefTitle":60,"officialTitle":61,"acronym":10,"eligibilityCriteria":62,"healthyVolunteers":63,"sex":64,"minAge":65,"maxAge":66,"enrollmentInfo":67,"targetDuration":10,"studyType":70,"phases":10,"briefSummary":71,"conditions":72,"keywords":75,"overallStatus":38,"whyStopped":10,"lastUpdateSubmitDate":77,"lastUpdatePostDateStruct":78,"startDateStruct":81,"completionDateStruct":83,"leadSponsor":85,"locationsCount":86},{"fullName":5,"class":6},"Tongji Hospital","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Appendectomy Group",null,"Patients with a history of appendectomy or right hemicolectomy (including appendectomy) are recruited. Subjects will undergo colonoscopy as per clinical routine, using PEG laxatives for bowel preparation. Fecal samples will be collected at 5 specific time points (pre-colonoscopy, first non-watery stool post-colonoscopy, 1 month, 3 months, and 6 months post-colonoscopy) for metagenomic sequencing analysis.",[13],"Drug: Bowel Preparation with Polyethylene Glycol (PEG) Laxatives",{"label":15,"type":10,"description":16,"interventionNames":17},"Non-Appendectomy Group","Age-matched healthy controls without a history of appendectomy or right hemicolectomy are recruited. Subjects will undergo colonoscopy as per clinical routine, using PEG laxatives for bowel preparation. Fecal samples will be collected at 5 specific time points (pre-colonoscopy, first non-watery stool post-colonoscopy, 1 month, 3 months, and 6 months post-colonoscopy) for metagenomic sequencing analysis.",[13],[19],{"type":20,"name":21,"description":22,"armGroupLabels":23,"otherNames":10},"DRUG","Bowel Preparation with Polyethylene Glycol (PEG) Laxatives","All subjects will undergo bowel preparation by taking Polyethylene Glycol (PEG) electrolyte powder according to the clinical routine requirements for colonoscopy. The specific dosage and administration will follow the hospital's standardized protocol. Researchers will record the usage of PEG.",[9,15],[25],{"name":26,"affiliation":27,"role":28},"ping h Xie, Doctor","Tongji Medical College of Huazhong University of Science and Technology","STUDY_CHAIR",[30],{"name":31,"role":32,"phone":33,"phoneExt":10,"email":34},"ping h Xie","CONTACT","86+13437187007","hpxie@tjh.tjmu.edu.cn",[36],{"facility":37,"status":38,"city":39,"state":40,"zip":41,"country":42,"countryCode":43,"cosmosGeoPoint":44,"geoPoint":49,"contacts":50},"Department of Gastroenterology Tongji Hospital, Tongji Medical college, Huazhong University of Science and technology","RECRUITING","Wuhan","Hubei","430030","China","CN",{"type":45,"coordinates":46},"Point",[47,48],114.26667,30.58333,{"lat":48,"lon":47},[51],{"name":31,"role":32,"phone":33,"phoneExt":10,"email":34},{"type":53,"investigatorFullName":54,"investigatorTitle":55,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"SPONSOR_INVESTIGATOR","Huaping Xie","Professor","100629696","clinical-study-of-peg-bowel-preparation-in-appendectomy-patients-100629696",false,"NCT07478029","Clinical Study of PEG Bowel Preparation in Appendectomy Patients","Impact of Polyethylene Glycol (PEG) Bowel Preparation on Intestinal Microbiota Composition and Diversity in Patients Undergoing Appendectomy","Inclusion Criteria:\n\n* Aged 18-75 years.\n* Scheduled to undergo colonoscopy.\n* Generally healthy without major organ diseases.\n\n  1. For appendectomy group: history of appendectomy or right hemicolectomy (including appendectomy).\n  2. For control group: no history of appendectomy or right hemicolectomy.\n\nExclusion Criteria:\n\n* Allergy or intolerance to PEG laxatives.\n* Pregnant or lactating women.\n* Mental disorders.\n* Use of antibiotics within 6 months prior to study enrollment.\n\n  1. Contraindications to colonoscopy (e.g., severe cardiopulmonary insufficiency).\n  2. For control group only: presence of organic diseases.",true,"ALL","18 Years","75 Years",{"count":68,"type":69},10,"ESTIMATED","OBSERVATIONAL","Colonoscopy is a necessary item of physical examination for colorectal cancer. For high-risk groups, annual physical examination is the most effective way of early prevention; At present, a large amount of polyethylene glycol (PEG2000 - 4000) is often used as laxative and lubricant in colonoscopy. However, the widespread use of PEG may cause long-term and irreversible damage to intestinal microorganisms and bring great hidden dangers to health. The appendix has long been regarded as a redundant organ in evolution. The incidence of appendicitis ranks first in surgical acute abdomen. Traditionally, once acute appendicitis is diagnosed, it is usually treated with appendectomy. However, recent studies have revealed that appendectomy may be associated with psychiatric diseases, colorectal cancer, cardiovascular diseases and other diseases. The appendix is not only an important organ of the immune system, but also undertakes the function of storing and protecting intestinal microbes.. . This change may affect the function of the central nervous system through the microbe gut brain axis, and then pose a potential threat to the health and behavior of the host, such as increasing the risk of diseases such as Parkinson's disease. Based on this, this clinical trial aims to investigate (1) the changes of intestinal flora in the appendectomy population before and after colonoscopy in the process of polyethylene glycol intestinal preparation; (2) the differences between the changes of intestinal flora before and after colonoscopy in the appendicectomy population and the normal population in the process of flora recovery.",[73,74],"Appendicitis","Appendicitis Acute",[21,76],"Gut microbiota","2026-03-13",{"date":79,"type":80},"2026-03-17","ACTUAL",{"date":82,"type":80},"2024-02-23",{"date":84,"type":69},"2027-03-18",{"name":54,"class":6},1]