[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100572534":3},{"organization":4,"armGroups":7,"interventions":14,"overallOfficials":21,"centralContacts":26,"locations":32,"responsibleParty":52,"collaborators":20,"id":54,"slug":55,"hasResults":56,"nctId":57,"briefTitle":58,"officialTitle":58,"acronym":20,"eligibilityCriteria":59,"healthyVolunteers":56,"sex":60,"minAge":61,"maxAge":62,"enrollmentInfo":63,"targetDuration":20,"studyType":66,"phases":67,"briefSummary":69,"conditions":70,"keywords":20,"overallStatus":48,"whyStopped":20,"lastUpdateSubmitDate":73,"lastUpdatePostDateStruct":74,"startDateStruct":77,"completionDateStruct":79,"leadSponsor":81,"locationsCount":82},{"fullName":5,"class":6},"Guangzhou Women and Children's Medical Center","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"Severe β -thalassemia","EXPERIMENTAL","Children with β-thalassemia major received super transplantation, and chimerism tests were performed at 3 months, 6 months, 9 months, and 1 year after transplantation to evaluate the safety and effectiveness.",[13],"Drug: super-transplantation in 3 severe β -thalassemia pediatric patients.",[15],{"type":16,"name":17,"description":18,"armGroupLabels":19,"otherNames":20},"DRUG","super-transplantation in 3 severe β -thalassemia pediatric patients.","Haplo-identical donors are mobilized with G-CSF and PBMCs that contain CD34+ stem cells and CD3+ lymphocytes will be extracted by blood cell separators. Then the patients will be infused with the PBMC",[9],null,[22],{"name":23,"affiliation":24,"role":25},"Hua Jiang, PHD","Guangzhou Medical University Affiliated Women's and Children's Medical Center","STUDY_DIRECTOR",[27],{"name":28,"role":29,"phone":30,"phoneExt":20,"email":31},"Hua Jiang, Doctor","CONTACT","86-020-38076501","jiang_hua18@sina.cn",[33,47],{"facility":34,"status":35,"city":36,"state":37,"zip":38,"country":39,"countryCode":40,"cosmosGeoPoint":41,"geoPoint":46,"contacts":20},"Guangzhou Women and Children's Medical Center Affiliated to Guangzhou Medical University","ACTIVE_NOT_RECRUITING","Guangzhou","Guangdong","51000","China","CN",{"type":42,"coordinates":43},"Point",[44,45],113.25,23.11667,{"lat":45,"lon":44},{"facility":34,"status":48,"city":36,"state":37,"zip":20,"country":39,"countryCode":40,"cosmosGeoPoint":49,"geoPoint":51,"contacts":20},"RECRUITING",{"type":42,"coordinates":50},[44,45],{"lat":45,"lon":44},{"type":53,"investigatorFullName":20,"investigatorTitle":20,"investigatorAffiliation":20,"oldNameTitle":20,"oldOrganization":20},"SPONSOR","100572534","clinical-study-of-super-transplantation-in-the-treatment-of-severe--thalassemia-100572534",false,"NCT06734520","Clinical Study of Super Transplantation in the Treatment of Severe β-thalassemia","Inclusion Criteria:\n\n1. Diagnosis of severe β -thalassemia\n2. Age between 7-10 years old, male and female; Weight \\\u003C 40kg\n3. The patient has or does not have an HLA-compatible or semi-compatible donor, but unconditional transplantation or refusal of blood stem cell transplantation; Patients with thalassemia gene therapy without conditions or refusal;\n4. There are fully compatible or incompatible HLA donors, and the physical examination meets the donor conditions;\n5. The patient and family members agree to receive hypertransplant therapy and sign a written informed consent prior to the transplant trial.\n\nExclusion Criteria:\n\n1. Mental patients;\n2. Participants in other drug clinical trials within the past 1 month;\n3. There are no suitable HLA-incompatible donors.\n4. Other researchers decide that it is not suitable to participate in this researcher.","ALL","7 Years","10 Years",{"count":64,"type":65},3,"ESTIMATED","INTERVENTIONAL",[68],"NA","This is a single-arm, open label, phase 1 study in subjects with beta-thalassemia. This study will evaluate the safety and efficacy of preconditioning-free super-transplantation on beta-thalassemia pediatric patients.",[71,72],"Thalassemia Majors (Beta-Thalassemia Major)","Haplo-identical Donors","2024-12-12",{"date":75,"type":76},"2024-12-16","ACTUAL",{"date":78,"type":76},"2024-10-01",{"date":80,"type":65},"2029-07-01",{"name":5,"class":6},2]