[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100642349":3},{"organization":4,"armGroups":7,"interventions":18,"overallOfficials":10,"centralContacts":23,"locations":10,"responsibleParty":29,"collaborators":10,"id":33,"slug":34,"hasResults":35,"nctId":36,"briefTitle":37,"officialTitle":38,"acronym":10,"eligibilityCriteria":39,"healthyVolunteers":40,"sex":41,"minAge":42,"maxAge":43,"enrollmentInfo":44,"targetDuration":10,"studyType":47,"phases":10,"briefSummary":48,"conditions":49,"keywords":52,"overallStatus":57,"whyStopped":10,"lastUpdateSubmitDate":58,"lastUpdatePostDateStruct":59,"startDateStruct":62,"completionDateStruct":64,"leadSponsor":66,"locationsCount":10},{"fullName":5,"class":6},"Capital Medical University","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Chronic Kidney Disease (CKD) Group",null,"Patients with chronic kidney disease (CKD) who undergo MRI-FF scans of the lumbar spine and thigh to evaluate bone mineral density and muscle fat fraction.",[13],"Other: MRI-FF Scan",{"label":15,"type":10,"description":16,"interventionNames":17},"Non-CKD Control Group","Control participants without chronic kidney disease, undergoing the same MRI-FF scans as the CKD group for comparison.",[13],[19],{"type":6,"name":20,"description":21,"armGroupLabels":22,"otherNames":10},"MRI-FF Scan","MRI fat-fraction (MRI-FF) scan of the lumbar spine and thigh, performed once for all participants to assess bone mineral density and muscle fat fraction.",[9,15],[24],{"name":25,"role":26,"phone":27,"phoneExt":10,"email":28},"Xiangcong Tian, MD","CONTACT","+86 15533929531","811214402@qq.com",{"type":30,"investigatorFullName":31,"investigatorTitle":32,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"PRINCIPAL_INVESTIGATOR","Dongliang Zhang, MD","Chief Physician, Professor, Department of Nephrology","100642349","clinical-study-on-a-new-diagnostic-strategy-for-osteoporosis-and-sarcopenia-in-chronic-kidney-disease-patients-based-on-mri-ff-100642349",false,"NCT07645794","Clinical Study on a New Diagnostic Strategy for Osteoporosis and Sarcopenia in Chronic Kidney Disease Patients Based on MRI-FF","A Clinical Study on Establishing a New Diagnostic Strategy for Osteoporosis and Sarcopenia in Patients With Chronic Kidney Disease Based on MRI-FFR","Inclusion Criteria:\n\n1. Age between 18 and 80 years old.\n2. Able to understand and sign the informed consent form.\n3. Able to complete MRI-FF scans of the lumbar spine and thigh.\n4. For CKD group: Confirmed diagnosis of chronic kidney disease (eGFR \\\u003C 60 mL\u002Fmin\u002F1.73m² for ≥3 months).\n5. For control group: No history of chronic kidney disease and normal renal function.\n\nExclusion Criteria:\n\n1. Contraindications to MRI (e.g., pacemaker, metal implants, severe claustrophobia).\n2. History of primary bone metabolic disorders (e.g., osteoporosis, hyperparathyroidism) unrelated to CKD.\n3. Current use of anti-osteoporotic drugs (e.g., bisphosphonates, teriparatide).\n4. Severe lower limb deformity or amputation affecting thigh muscle assessment.\n5. Inability to cooperate with the scan due to cognitive impairment or severe illness.",true,"ALL","18 Years","80 Years",{"count":45,"type":46},868,"ESTIMATED","OBSERVATIONAL","This is a single-center, observational cohort study aiming to validate the diagnostic value of MRI-FF in identifying osteoporosis and sarcopenia in patients with chronic kidney disease (CKD). A total of 868 participants, including 434 CKD patients and 434 non-CKD controls, will be enrolled at Beijing Jishuitan Hospital. All subjects will undergo MRI-FF scans of the lumbar spine and thigh to assess bone mineral density and muscle fat fraction. The primary objective is to evaluate the correlation between MRI-FF parameters and conventional diagnostic criteria for osteoporosis and sarcopenia, as well as to determine the optimal cut-off values for early detection. The study duration is from March 2026 to December 2028.",[50,51],"Chronic Kidney Disease","Osteoporosis",[50,51,53,54,55,56],"Sarcopenia","MRI-FF","Bone Mineral Density","Muscle Fat Fraction","NOT_YET_RECRUITING","2026-06-09",{"date":60,"type":61},"2026-06-12","ACTUAL",{"date":63,"type":46},"2026-06",{"date":65,"type":46},"2028-12",{"name":5,"class":6}]