[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100620002":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":26,"centralContacts":32,"locations":38,"responsibleParty":53,"collaborators":26,"id":55,"slug":56,"hasResults":57,"nctId":58,"briefTitle":59,"officialTitle":59,"acronym":26,"eligibilityCriteria":60,"healthyVolunteers":57,"sex":61,"minAge":62,"maxAge":63,"enrollmentInfo":64,"targetDuration":26,"studyType":67,"phases":68,"briefSummary":70,"conditions":71,"keywords":73,"overallStatus":41,"whyStopped":26,"lastUpdateSubmitDate":74,"lastUpdatePostDateStruct":75,"startDateStruct":78,"completionDateStruct":80,"leadSponsor":82,"locationsCount":83},{"fullName":5,"class":6},"Shanghai Children's Medical Center","OTHER",[8,15],{"label":9,"type":10,"description":11,"interventionNames":12},"Intervention Group","EXPERIMENTAL","The child will use a transcranial magnetic stimulator model ZL-N-010 to stimulate preselected targets located in the prefrontal lobe, bilateral temporal lobes, and parietal lobe. The child may rest as needed during the treatment process. Each TMS session lasts approximately 30 minutes. A total of 10 sessions will be administered. They will also use general behavioral therapy.",[13,14],"Device: Transcranial Magnetic Stimulation","Behavioral: general behavioral therapy",{"label":16,"type":17,"description":18,"interventionNames":19},"Sham-Controlled Observation Group","PLACEBO_COMPARATOR","The child will receive sham stimulation and general behavioral therapy.",[14],[21,27],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"DEVICE","Transcranial Magnetic Stimulation","Transcranial magnetic stimulation (TMS) will be administered to the child using a ZL-N-010 model device, targeting predefined sites in the prefrontal, bilateral temporal, and parietal lobes.",[9],null,{"type":28,"name":29,"description":30,"armGroupLabels":31,"otherNames":26},"BEHAVIORAL","general behavioral therapy","Behavioral interventions include avoiding screen time, parental avoidance of scolding or corporal punishment, and steering clear of activities or emotional stimuli that may exacerbate symptoms.",[9,16],[33],{"name":34,"role":35,"phone":36,"phoneExt":26,"email":37},"Jun Ma, M.D.","CONTACT","13917230745","majun@shsmu.edu.cn",[39],{"facility":40,"status":41,"city":42,"state":43,"zip":44,"country":45,"countryCode":46,"cosmosGeoPoint":47,"geoPoint":52,"contacts":26},"Shanghai Children's Medical Center，School of Medicine, Shanghai Jiao Tong University","RECRUITING","Shanghai","Shanghai Municipality","200127","China","CN",{"type":48,"coordinates":49},"Point",[50,51],121.45806,31.22222,{"lat":51,"lon":50},{"type":54,"investigatorFullName":26,"investigatorTitle":26,"investigatorAffiliation":26,"oldNameTitle":26,"oldOrganization":26},"SPONSOR","100620002","clinical-study-on-a-novel-strategy-of-individualized-non-invasive-neuromodulation-for-the-treatment-of-tic-disorders-in-children-100620002",false,"NCT07351955","Clinical Study on a Novel Strategy of Individualized Non-Invasive Neuromodulation for the Treatment of Tic Disorders in Children","Inclusion Criteria:\n\n* 1: Children and adolescents aged 5 to 18 years\n\n  2: Meets DSM-5 diagnostic criteria for Tic Disorders (TDs) with normal EEG findings\n\n  3: No prior treatment received for TDs\n\n  4: Full-scale intelligence quotient (FIQ) ≥70 on the Wechsler Intelligence Scale for Children-Revised (WISC-R)\n\nExclusion Criteria:\n\n* 1: WISC-R Full-Scale Intelligence Quotient (FIQ) \\\u003C70\n\n  2: Presence of metal implants in the body ，Non-right-handedness\n\n  3: Head movement (HM) \\>2mm during fMRI scanning, including both translational movement (TM) and rotational movement (RM)\n\n  4: Any other neurological or psychiatric conditions, including but not limited to autism spectrum disorder (ASD), epilepsy, obsessive-compulsive disorder (OCD), etc\n\n  5: Previous head trauma ，Neurological diseases ，Major systemic illnesses","ALL","5 Months","18 Years",{"count":65,"type":66},60,"ESTIMATED","INTERVENTIONAL",[69],"NA","This study aims to establish a novel personalized closed-loop NiBS\u002FTMS therapeutic strategy and clinical protocol for children with Tic Disorders (TDs) through a series of scientific investigations. Additionally, it seeks to elucidate the underlying neural circuit mechanisms, enhance the therapeutic efficacy of TMS in pediatric TDs, and achieve precision neuromodulation for children with TDs.",[72],"Tic Disorders",[23],"2026-01-11",{"date":76,"type":77},"2026-01-20","ACTUAL",{"date":79,"type":77},"2025-06-01",{"date":81,"type":66},"2026-05-31",{"name":5,"class":6},1]