[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100471367":3},{"organization":4,"armGroups":7,"interventions":27,"overallOfficials":32,"centralContacts":32,"locations":37,"responsibleParty":57,"collaborators":32,"id":61,"slug":62,"hasResults":63,"nctId":64,"briefTitle":65,"officialTitle":66,"acronym":32,"eligibilityCriteria":67,"healthyVolunteers":63,"sex":68,"minAge":69,"maxAge":32,"enrollmentInfo":70,"targetDuration":32,"studyType":73,"phases":74,"briefSummary":76,"conditions":77,"keywords":32,"overallStatus":39,"whyStopped":32,"lastUpdateSubmitDate":79,"lastUpdatePostDateStruct":80,"startDateStruct":83,"completionDateStruct":85,"leadSponsor":87,"locationsCount":88},{"fullName":5,"class":6},"Boston Children's Hospital","OTHER",[8,15,19,23],{"label":9,"type":10,"description":11,"interventionNames":12},"Extremely Thick - Mildly Thick - Extremely Thick - Mildly Thick","EXPERIMENTAL","Participants will receive 4 weeks Extremely Thick, 4 weeks Mildly Thick, 4 weeks Extremely Thick and 4 weeks Mildly Thick blenderized tube feeds. The volume, caloric density and frequency will be matched to pre-study feeding regimen.",[13,14],"Other: Extremely thick blenderized tube feed","Other: Mildly thick blenderized tube feed",{"label":16,"type":10,"description":17,"interventionNames":18},"Extremely Thick - Mildly Thick - Mildly Thick - Extremely Thick","Participants will receive 4 weeks Extremely Thick, 4 weeks Mildly Thick, 4 weeks Mildly Thick and 4 weeks Extremely Thick blenderized tube feeds. The volume, caloric density and frequency will be matched to pre-study feeding regimen.",[13,14],{"label":20,"type":10,"description":21,"interventionNames":22},"Mildly Thick - Extremely Thick - Extremely Thick - Mildly Thick","Participants will receive 4 weeks Mildly Thick, 4 weeks Extremely Thick, 4 weeks Extremely Thick and 4 weeks Mildly Thick blenderized tube feeds. The volume, caloric density and frequency will be matched to pre-study feeding regimen.",[13,14],{"label":24,"type":10,"description":25,"interventionNames":26},"Mildly Thick - Extremely Thick - Mildly Thick - Extremely Thick","Participants will receive 4 weeks Mildly Thick, 4 weeks Extremely Thick, 4 weeks Mildly Thick and 4 weeks Extremely Thick blenderized tube feeds. The volume, caloric density and frequency will be matched to pre-study feeding regimen.",[13,14],[28,33],{"type":6,"name":29,"description":30,"armGroupLabels":31,"otherNames":32},"Extremely thick blenderized tube feed","Commercial blenderized tube feed, not diluted",[9,16,20,24],null,{"type":6,"name":34,"description":35,"armGroupLabels":36,"otherNames":32},"Mildly thick blenderized tube feed","Commercial blenderized tube feed, diluted with ingredients contained in blend",[9,16,20,24],[38],{"facility":5,"status":39,"city":40,"state":41,"zip":42,"country":43,"countryCode":44,"cosmosGeoPoint":45,"geoPoint":50,"contacts":51},"RECRUITING","Boston","Massachusetts","02115","United States","US",{"type":46,"coordinates":47},"Point",[48,49],-71.05977,42.35843,{"lat":49,"lon":48},[52],{"name":53,"role":54,"phone":55,"phoneExt":32,"email":56},"Bridget M Hron, MD","CONTACT","6173551433","bridget.hron@childrens.harvard.edu",{"type":58,"investigatorFullName":59,"investigatorTitle":60,"investigatorAffiliation":5,"oldNameTitle":32,"oldOrganization":32},"PRINCIPAL_INVESTIGATOR","Bridget Hron","Staff Physician","100471367","clinical-trial-of-blenderized-tube-feeds-varying-in-viscosity-100471367",false,"NCT05417958","Clinical Trial of Blenderized Tube Feeds Varying in Viscosity","A Novel N-of-1 Randomized, Controlled, Clinical Trial to Assess the Effect of Blenderized Tube Feeds on Esophagogastric Physiology","Inclusion Criteria:\n\n* age \\> 1 year\n* \\>90% of total calories via G-tube for \\> 6 months\n* G-tube diameter ≥ 14 French\n* moderate severity of upper GI symptoms of nausea, bloating, postprandial fullness and early satiety defined as Gastroparesis Cardinal Symptom Index-Daily Diary (GCSI-DD) composite score \\> 2\n* anticipated stable GI-related medications for the duration of the study.\n\nExclusion Criteria:\n\n* cystic fibrosis, primary ciliary dyskinesia, interstitial lung disease, bronchiolitis obliterans, or lung transplant\n* untreated malabsorptive intestinal disease (e.g. Crohn's disease, celiac disease)\n* Nissen fundoplication\n* use of non-standard enteral formulas (e.g. ketogenic formulas) for the management of metabolic, endocrine or neurologic rare diseases\n* allergy or intolerance to any component of the study diet\n* inability to tolerate bolus gastric feeds.","ALL","1 Year",{"count":71,"type":72},40,"ESTIMATED","INTERVENTIONAL",[75],"NA","The investigators are conducting a 16 week multiple cross-over study (N-of-1 trial) comparing two blenderized tube feeds varying in viscosity in 40 children.",[78],"Feeding Disorders","2026-04-14",{"date":81,"type":82},"2026-04-17","ACTUAL",{"date":84,"type":82},"2023-10-12",{"date":86,"type":72},"2028-04-01",{"name":5,"class":6},1]