[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100556535":3},{"organization":4,"armGroups":7,"interventions":14,"overallOfficials":19,"centralContacts":24,"locations":30,"responsibleParty":46,"collaborators":48,"id":54,"slug":55,"hasResults":56,"nctId":57,"briefTitle":58,"officialTitle":59,"acronym":10,"eligibilityCriteria":60,"healthyVolunteers":56,"sex":61,"minAge":62,"maxAge":10,"enrollmentInfo":63,"targetDuration":10,"studyType":66,"phases":10,"briefSummary":67,"conditions":68,"keywords":73,"overallStatus":32,"whyStopped":10,"lastUpdateSubmitDate":80,"lastUpdatePostDateStruct":81,"startDateStruct":84,"completionDateStruct":86,"leadSponsor":88,"locationsCount":89},{"fullName":5,"class":6},"University Hospital, Basel, Switzerland","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"MS patients",null,"MS patients, recruited from the SMSC, are annually (optional 6-monthly) assessed and additionally, perform digital measurements with the Healios+Me app continuously after baseline up to 5 years as an optional follow-up study extension.",[13],"Other: All participants will be asked to provide data and samples for collection and analysis.",[15],{"type":6,"name":16,"description":17,"armGroupLabels":18,"otherNames":10},"All participants will be asked to provide data and samples for collection and analysis.","During the first year, data related to demographics, lifestyle, clinical examinations will be collected at baseline, at 6 months (optional) and at 12 months. PROs, cognitive and motor assessments will be performed using the Healios+Me smartphone app. Additionally, participants will be asked to provide biological samples (i.e., blood, cerebrospinal fluid and stool, saliva and hair) and imaging data (if performed as per standard of care). One unscheduled visit may be performed in case the participant comes to the hospital with the occurrence of flare or for a treatment change.\n\nA long-term follow-up (FU, starting from month 12 and up to 4 years after month 12) is foreseen in this study. During the long-term FU medical data are collected either every 6 month or on a yearly basis, and PROs are collected every 6 months. Whether study visits are conducted in 6- or 12-monthly intervals depends on the schedule of the study visits for the Swiss MS cohort (SMSC).",[9],[20],{"name":21,"affiliation":22,"role":23},"Cristina Granziera, Prof.","Research Center for Clinical Neuroimmunology and Neuroscience Basel (RC2NB)","PRINCIPAL_INVESTIGATOR",[25],{"name":26,"role":27,"phone":28,"phoneExt":10,"email":29},"Bebeka Cosandey (Clinnova:Scientific Project Lead), PhD","CONTACT","+41 79 961 26 31","bebeka.cosandey@usb.ch",[31],{"facility":22,"status":32,"city":33,"state":10,"zip":34,"country":35,"countryCode":36,"cosmosGeoPoint":37,"geoPoint":42,"contacts":43},"RECRUITING","Basel","4031","Switzerland","CH",{"type":38,"coordinates":39},"Point",[40,41],7.57327,47.55839,{"lat":41,"lon":40},[44,45],{"name":26,"role":27,"phone":28,"phoneExt":10,"email":29},{"name":21,"role":23,"phone":10,"phoneExt":10,"email":10},{"type":47,"investigatorFullName":10,"investigatorTitle":10,"investigatorAffiliation":10,"oldNameTitle":10,"oldOrganization":10},"SPONSOR",[49,52],{"name":50,"class":51},"Luxembourg Institute of Health","OTHER_GOV",{"name":53,"class":6},"Research Center for Clinical Neuroimmunology and Neuroscience Basel","100556535","clinnova-ms-a-prospective-cohort-study-of-patients-with-multiple-sclerosis-switzerland-100556535",false,"NCT06526364","Clinnova-MS: A Prospective Cohort Study of Patients With Multiple Sclerosis (Switzerland)","Clinnova-MS: a Prospective Cohort Study of Patients With Multiple Sclerosis: A Trans-Regional Digital Health Effort Unlocking the Potential of Artificial Intelligence and Data Science in Health Care (Switzerland)","Inclusion Criteria:\n\n* Age ≥18\n* Participants are willing and able to comply with the protocol, including undergoing data and samples collection as well as study visits and examinations.\n* Signed informed consent form\n* In possession of a Healios+Me app compatible smartphone (iOS\u002FAndroid)\n* Corrected close visual acuity of ≥0.5\n* Hand motor skills sufficient for using a smartphone\n* Ability to follow the study procedures\n* Diagnosed with MS according to the revised McDonald criteria 2017, all clinical forms inclusive (clinically isolated syndrome, RRMS, SPMS, PPMS) AND early disease stages (\\\u003C 3 years) OR transitioning phase to progressive disease as evaluated based on Expanded Disability Status Scale (EDSS).\n* Enrolled in the SMSC at University Hospital Basel\n\nThere are no specific exclusion criteria.","ALL","18 Years",{"count":64,"type":65},100,"ESTIMATED","OBSERVATIONAL","This prospective cohort study is part of the Clinnova programme and aims to (i) identify clinical imaging and omics characteristics associated with early Multiple Sclerosis (MS) and with transitioning phases to progressive MS, as well as (ii) to investigate digital biomarkers allowing the continuous clinical monitoring of those patients.",[69,70,71,72],"Multiple Sclerosis","Multiple Sclerosis, Relapsing-Remitting","Multiple Sclerosis, Primary Progressive","Multiple Sclerosis, Secondary Progressive",[74,75,76,77,78,79],"Immune-meditated Diseases","Artificial Intelligence","Personalized medicine","Treatment change","Phenotyping","Clinnova","2025-12-18",{"date":82,"type":83},"2025-12-26","ACTUAL",{"date":85,"type":83},"2024-12-10",{"date":87,"type":65},"2029-06",{"name":5,"class":6},1]