[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100630419":3},{"organization":4,"armGroups":7,"interventions":14,"overallOfficials":20,"centralContacts":25,"locations":34,"responsibleParty":53,"collaborators":19,"id":55,"slug":56,"hasResults":57,"nctId":58,"briefTitle":59,"officialTitle":60,"acronym":61,"eligibilityCriteria":62,"healthyVolunteers":57,"sex":63,"minAge":64,"maxAge":19,"enrollmentInfo":65,"targetDuration":19,"studyType":68,"phases":69,"briefSummary":71,"conditions":72,"keywords":74,"overallStatus":37,"whyStopped":19,"lastUpdateSubmitDate":77,"lastUpdatePostDateStruct":78,"startDateStruct":81,"completionDateStruct":83,"leadSponsor":85,"locationsCount":86},{"fullName":5,"class":6},"Technical University of Munich","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"Dietary intervention","EXPERIMENTAL","All participants will receive nutrition counselling and partake in the WFPB diet for 4 weeks. Participants will be asked to keep a food diary.",[13],"Other: Diet",[15],{"type":6,"name":16,"description":17,"armGroupLabels":18,"otherNames":19},"Diet","For 4 weeks the participants will sick to a whole-food plant-based diet and keep a food diary. Recommendations and guidelines will be given during a nutritional counselling.",[9],null,[21],{"name":22,"affiliation":23,"role":24},"Maike Buchner-Mayr, PD Dr.","Technisch Universität München","PRINCIPAL_INVESTIGATOR",[26,30],{"name":22,"role":27,"phone":28,"phoneExt":19,"email":29},"CONTACT","+498941409255","Maike.Buchner@tum.de",{"name":31,"role":27,"phone":32,"phoneExt":19,"email":33},"Anna Herr, MSc","+498941404159","Anna.Herr@tum.de",[35],{"facility":36,"status":37,"city":38,"state":39,"zip":40,"country":41,"countryCode":42,"cosmosGeoPoint":43,"geoPoint":48,"contacts":49},"Klinikum der Technischen Universität München (Klinikum rechts der Isar)","RECRUITING","München","Bavaria","81676","Germany","DE",{"type":44,"coordinates":45},"Point",[46,47],13.46314,48.69668,{"lat":47,"lon":46},[50],{"name":51,"role":27,"phone":19,"phoneExt":19,"email":52},"Manuel Knauer, Dr.","Manuel.Knauer@mri.tum.de",{"type":54,"investigatorFullName":19,"investigatorTitle":19,"investigatorAffiliation":19,"oldNameTitle":19,"oldOrganization":19},"SPONSOR","100630419","cll-impact-a-clinical-nutrition-trial-investigating-immune-and-metabolic-changes-in-early-stage-cll-100630419",false,"NCT07487428","CLL-IMPACT: A Clinical Nutrition Trial Investigating Immune and Metabolic Changes in Early-Stage CLL","An Interventional Study of Dietary Effects on Immune Function, Metabolism and Disease Activity in Early-Stage Chronic Lymphocytic Leukemia","CLL-IMPACT","Inclusion Criteria:\n\n* Confirmed CLL diagnosis\n* No previous treatments (watch and wait)\n* Willingness to comply to a whole-food plant-based diet for 4 weeks\n* Willingness to participate in a total of 3 blood drawings\n\nExclusion Criteria:\n\n* Emergency interventions\n* Patients that already follow a WFPB or vegan diet\n* Progression of CLL that implicates need for treatment\n* Insulin-dependent diabetes\n* Taking lipid-lowering medications (e.g. statins)\n* Body mass index (BMI) \\\u003C20 And if in the opinion of the investigator there are any concerns regarding the ability of the patient to complete the study safely.","ALL","18 Years",{"count":66,"type":67},50,"ESTIMATED","INTERVENTIONAL",[70],"NA","The goal of this clinical trial is to investigate whether a short-term (4-week) whole-food, plant-based (WFPB) diet has an effect on metabolism, immune function, and disease activity in early-stage chronic lymphocytic leukemia (CLL). The main questions the study aims to answer are:\n\n* Does a WFPB diet influence disease progression?\n* How do CLL cells and other immune cell types respond to a WFPB diet in terms of metabolism and signaling?\n\nResearchers will examine whether a WFPB diet can affect absolute lymphocyte counts in participants' blood and what metabolic or functional changes occur within the CLL cells.\n\nParticipants will:\n\n* Switch to a WFPB diet for 4 weeks following an introductory session with a certified dietary instructor.\n* Visit the clinic before starting the diet and again after 14 and 28 days for blood draws and to provide stool samples.\n* Keep a diary of all foods and drinks consumed during the week prior to and throughout the study period.",[73],"CLL (Chronic Lymphocytic Leukemia)",[16,75,76],"Nutrition","Plant-based diet","2026-03-17",{"date":79,"type":80},"2026-03-23","ACTUAL",{"date":82,"type":80},"2024-01-01",{"date":84,"type":67},"2028-06-30",{"name":5,"class":6},1]