[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100369344":3},{"organization":4,"armGroups":7,"interventions":27,"overallOfficials":37,"centralContacts":42,"locations":51,"responsibleParty":64,"collaborators":32,"id":67,"slug":68,"hasResults":69,"nctId":70,"briefTitle":71,"officialTitle":72,"acronym":73,"eligibilityCriteria":74,"healthyVolunteers":69,"sex":75,"minAge":76,"maxAge":32,"enrollmentInfo":77,"targetDuration":32,"studyType":80,"phases":81,"briefSummary":83,"conditions":84,"keywords":86,"overallStatus":92,"whyStopped":32,"lastUpdateSubmitDate":93,"lastUpdatePostDateStruct":94,"startDateStruct":97,"completionDateStruct":99,"leadSponsor":101,"locationsCount":102},{"fullName":5,"class":6},"Izmir Dr Suat Seren Chest Diseases and Surgery Education and Research Hospital","OTHER",[8,14,19,23],{"label":9,"type":10,"description":11,"interventionNames":12},"1.1. ASV, MV target 100%","EXPERIMENTAL","Patients will be ventilated with ASV mode. Tidal volume, ventilation frequency, inspiratory duration will be automatically adjusted by the mechanical ventilator.",[13],"Other: Minute volume target of 100%",{"label":15,"type":16,"description":17,"interventionNames":18},"1.2. Volume control, MV target %100","ACTIVE_COMPARATOR","Patients will be ventilated with volume control mode. A tidal volume of 6-8 ml\u002Fkg will be used. I:E ratio will be set as 1:3 Ventilation frequency will be adjusted to reach the same volume target calculated in arm1.",[13],{"label":20,"type":10,"description":11,"interventionNames":21},"2.1. ASV, MV target to reach PaCO2\u003C 45 mmHg",[22],"Other: Minute volume target to reach PaCO2 less than 45% (high tidal volume)",{"label":24,"type":16,"description":25,"interventionNames":26},"2.2. Volume control, MV target to reach PaCO2\u003C 45 mmHg","Patients will be ventilated with volume control mode. A tidal volume of 6-8 ml\u002Fkg will be used. I:E ratio will be set as 1:3. Ventilation frequency will be adjusted to reach the target PaCO2 level",[22],[28,33],{"type":6,"name":29,"description":30,"armGroupLabels":31,"otherNames":32},"Minute volume target of 100%","Patients will be ventilated to reach minute volume target of %100 (100 ml per ideal body weight).",[9,15],null,{"type":6,"name":34,"description":35,"armGroupLabels":36,"otherNames":32},"Minute volume target to reach PaCO2 less than 45% (high tidal volume)","Patients will be ventilated to reach minute volume target associated with PaCO2 less than 45%.",[20,24],[38],{"name":39,"affiliation":40,"role":41},"Sami C Kirakli, MD","Dr. Suat Seren Chest Diseases and Surgery Educatin and Resarch Hospital","PRINCIPAL_INVESTIGATOR",[43,47],{"name":39,"role":44,"phone":45,"phoneExt":32,"email":46},"CONTACT","+905052352024","samicenk.kirakli@sbu.edu.tr",{"name":48,"role":44,"phone":49,"phoneExt":32,"email":50},"Burcu Acar Cinleti, MD","+905075022780","burcu_acar911@yahoo.com",[52],{"facility":53,"status":32,"city":54,"state":55,"zip":56,"country":57,"countryCode":32,"cosmosGeoPoint":58,"geoPoint":63,"contacts":32},"Izmir Dr. Suat Seren Chest Diseases and Surgery Education and Research Hospital, Intensive Care Unit","Izmir","Yenisehir","35550","Turkey (Türkiye)",{"type":59,"coordinates":60},"Point",[61,62],27.13838,38.41273,{"lat":62,"lon":61},{"type":41,"investigatorFullName":65,"investigatorTitle":66,"investigatorAffiliation":5,"oldNameTitle":32,"oldOrganization":32},"Cenk Kirakli, M.D.","Associate Professor Cenk Kirakli. M.D.","100369344","closed-loop-ventilation-with-high-tidal-volumes-and-safe-transpulmonary-pressure-in-copd-copd-safe-100369344",false,"NCT04089111","Closed Loop Ventilation With High Tidal Volumes and Safe Transpulmonary Pressure in COPD (COPD-SAFE)","Does Automatically Generated Tidal Volumes With Closed-loop Ventilation Leads to Safe Transpulmonary Pressures in Intubated Chronic Obstructive Pulmonary Disease Patients?","COPD-SAFE","Inclusion Criteria:\n\n* Acute exacerbation of Chronic Obstructive Lung Disease\n* Being intubated for less than 24 hours\n* Not being planned to be extubated in 24 hours\n* Expiratory time constant (RCexp) more than \\> 2.0 s\n\nExclusion Criteria:\n\n* Restrictive lung pathologies\n* Impaired hemodynamic status\n* Esophageal pathologies\n* Bronchopleural fistula","ALL","18 Years",{"count":78,"type":79},20,"ESTIMATED","INTERVENTIONAL",[82],"NA","This study evaluates the safety and efficacy of high tidal volumes generated by \"Adapted Support Ventilation (ASV) mode' in mechanically ventilated severe COPD patients. Every patient will be ventilated consecutively with ASV and Volume Control (VC) modes at 2 different levels of minute volume in 2 sets. ASV mode is expected to be safe measured by adequate inspiratory transpulmonary pressures and expected to be as effective as VC mode with lower intrinsic positive end expiratory pressure (iPEEP) levels.",[85],"Chronic Obstructive Pulmonary Disease",[87,88,89,90,91],"Mechanical ventilation","Adaptive Support Ventilation","Transpulmonary pressure","Intrinsic PEEP","Safety","NOT_YET_RECRUITING","2024-10-12",{"date":95,"type":96},"2024-10-15","ACTUAL",{"date":98,"type":79},"2024-12",{"date":100,"type":79},"2025-02",{"name":5,"class":6},1]