[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100611846":3},{"organization":4,"armGroups":7,"interventions":10,"overallOfficials":10,"centralContacts":12,"locations":18,"responsibleParty":72,"collaborators":74,"id":89,"slug":90,"hasResults":91,"nctId":92,"briefTitle":93,"officialTitle":94,"acronym":95,"eligibilityCriteria":96,"healthyVolunteers":91,"sex":97,"minAge":98,"maxAge":10,"enrollmentInfo":99,"targetDuration":10,"studyType":102,"phases":10,"briefSummary":103,"conditions":104,"keywords":107,"overallStatus":49,"whyStopped":10,"lastUpdateSubmitDate":111,"lastUpdatePostDateStruct":112,"startDateStruct":115,"completionDateStruct":117,"leadSponsor":119,"locationsCount":120},{"fullName":5,"class":6},"Region Skane","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":10},"Patients with suspected ventilator-associated pneumonia",null,"Adult ICU patients receiving mechanical ventilation who undergo bronchoalveolar lavage (BAL) or mini-BAL for clinical suspicion of lower respiratory tract infection. Residual BAL fluid will be analyzed using proteomic profiling to identify biological subgroups (\"pneumoclusters\"). No experimental intervention is administered; all patients receive standard care.",[13],{"name":14,"role":15,"phone":16,"phoneExt":10,"email":17},"Magnus Paulsson, MD PhD","CONTACT","+46703124424","magnus.paulsson@med.lu.se",[19,34,47,61],{"facility":20,"status":21,"city":22,"state":10,"zip":10,"country":23,"countryCode":24,"cosmosGeoPoint":25,"geoPoint":30,"contacts":31},"CHU Limoges","NOT_YET_RECRUITING","Limoges","France","FR",{"type":26,"coordinates":27},"Point",[28,29],1.24759,45.83362,{"lat":29,"lon":28},[32],{"name":33,"role":15,"phone":10,"phoneExt":10,"email":10},"Julien Vaidie",{"facility":35,"status":21,"city":36,"state":10,"zip":10,"country":37,"countryCode":38,"cosmosGeoPoint":39,"geoPoint":43,"contacts":44},"Hospital de São Francisco Xavier","Lisbon","Portugal","PT",{"type":26,"coordinates":40},[41,42],-9.1498,38.72509,{"lat":42,"lon":41},[45],{"name":46,"role":15,"phone":10,"phoneExt":10,"email":10},"Pedro Povoa",{"facility":48,"status":49,"city":50,"state":10,"zip":10,"country":51,"countryCode":52,"cosmosGeoPoint":53,"geoPoint":57,"contacts":58},"Skånes universitetssjukhus","RECRUITING","Lund","Sweden","SE",{"type":26,"coordinates":54},[55,56],13.19321,55.70584,{"lat":56,"lon":55},[59],{"name":60,"role":15,"phone":10,"phoneExt":10,"email":10},"Magnus Paulsson",{"facility":62,"status":49,"city":63,"state":10,"zip":10,"country":51,"countryCode":52,"cosmosGeoPoint":64,"geoPoint":68,"contacts":69},"Karolinska universitetssjukhuset","Stockholm",{"type":26,"coordinates":65},[66,67],18.06871,59.32938,{"lat":67,"lon":66},[70],{"name":71,"role":15,"phone":10,"phoneExt":10,"email":10},"Johan Petersson, MD PhD",{"type":73,"investigatorFullName":10,"investigatorTitle":10,"investigatorAffiliation":10,"oldNameTitle":10,"oldOrganization":10},"SPONSOR",[75,77,79,81,83,85,87],{"name":76,"class":6},"Lund University",{"name":78,"class":6},"NOVA Medical School",{"name":80,"class":6},"Rigshospitalet, Denmark",{"name":82,"class":6},"Karolinska University Hospital",{"name":84,"class":6},"University Hospital, Limoges",{"name":86,"class":6},"King's College Hospital NHS Trust",{"name":88,"class":6},"Umeå University","100611846","clustervap-multicentre-proteomic-endotyping-of-ventilator-associated-pneumonia-100611846",false,"NCT07245888","ClusterVAP: Multicentre Proteomic Endotyping of Ventilator-associated Pneumonia","Endotyping of Ventilator-associated Pneumonia With Proteomics on Bronchoalveolar Lavage for Improved Diagnosis, the ClusterVAP Study","ClusterVAP","Inclusion Criteria:\n\nAdult patients (≥18 years) admitted to an intensive care unit (ICU). Receiving invasive mechanical ventilation. Undergoing bronchoalveolar lavage (BAL) or mini-BAL on clinical indication for suspected lower respiratory tract infection.\n\nNew or worsening clinical signs compatible with lower respiratory tract infection within the preceding 24 hours, defined as the treating clinician's suspicion plus at least one of:\n\nBody temperature \\>38 °C or \\\u003C36 °C. Visually purulent tracheal secretions. Signs of reduced oxygenation (e.g., increased FiO₂ and\u002For decreased arterial pO₂, increased positive end-expiratory pressure or driving pressure).\n\nRequest for chest radiograph to investigate infection or new infiltrate. Initiation of antibiotic therapy targeting lower respiratory tract infection.\n\nExclusion Criteria:\n\nBAL or mini-BAL performed solely for screening without suspicion of infection. Concurrent enrolment in the VAPmarkers study (reserved for external validation).\n\nAge \\\u003C18 years. Any condition that, in the opinion of the investigator, would preclude safe participation or confound study objectives.","ALL","18 Years",{"count":100,"type":101},400,"ESTIMATED","OBSERVATIONAL","Ventilator-associated pneumonia (VAP) is a common and serious infection in patients receiving mechanical ventilation in intensive care units. Current diagnostic methods are imprecise, leading to unnecessary antibiotic use and delayed treatment. The ClusterVAP study aims to identify biologically and clinically distinct subgroups of patients with suspected VAP by analyzing proteins in bronchoalveolar lavage (BAL) fluid using advanced proteomic techniques. This multicentre observational study will enroll approximately 400 adult patients from intensive care units in Sweden, France, Portugal, Denmark, and the United Kingdom. BAL or mini-BAL samples collected for clinical reasons will be analyzed to define \"pneumoclusters\" and explore their association with patient outcomes. The study will also identify candidate biomarkers that could support future diagnostic tools. No experimental treatments are given; all patients receive standard care. Results may improve diagnostic accuracy and guide personalized treatment strategies for critically ill patients.",[105,106],"Ventilator Acquired Pneumonia","Mechanical Ventilation Complication",[108,109,110],"VAP","endotyping","mini-BAL","2026-06-25",{"date":113,"type":114},"2026-06-30","ACTUAL",{"date":116,"type":114},"2026-05-01",{"date":118,"type":101},"2027-12",{"name":5,"class":6},4]