[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100607427":3},{"organization":4,"armGroups":7,"interventions":18,"overallOfficials":12,"centralContacts":24,"locations":34,"responsibleParty":54,"collaborators":12,"id":58,"slug":59,"hasResults":60,"nctId":61,"briefTitle":62,"officialTitle":63,"acronym":12,"eligibilityCriteria":64,"healthyVolunteers":60,"sex":65,"minAge":66,"maxAge":67,"enrollmentInfo":68,"targetDuration":12,"studyType":71,"phases":72,"briefSummary":74,"conditions":75,"keywords":77,"overallStatus":37,"whyStopped":12,"lastUpdateSubmitDate":79,"lastUpdatePostDateStruct":80,"startDateStruct":83,"completionDateStruct":85,"leadSponsor":87,"locationsCount":88},{"fullName":5,"class":6},"University of Iowa","OTHER",[8,13],{"label":9,"type":10,"description":11,"interventionNames":12},"OP","NO_INTERVENTION","Charcot-Marie-Tooth patients who have undergone surgical correction but do not wear ankle-foot orthoses.",null,{"label":14,"type":6,"description":15,"interventionNames":16},"NonOP","Charcot-Marie-Tooth patients who have not undergone surgical correction, but do wear clinically prescribed ankle-foot orthoses. NonOP subjects will complete study procedures both with and without their AFOs.",[17],"Device: Ankle-foot Orthoses",[19],{"type":20,"name":21,"description":22,"armGroupLabels":23,"otherNames":12},"DEVICE","Ankle-foot Orthoses","Group 1 will consist of individuals who have CMT and have undergone surgical correction (OP) and Group 2 will be AFO users who have CMT but have not undergone major surgical correction (NonOP).",[14],[25,30],{"name":26,"role":27,"phone":28,"phoneExt":12,"email":29},"Bopha Chrea, MD","CONTACT","319-356-3943","bopha-chrea@uiowa.edu",{"name":31,"role":27,"phone":32,"phoneExt":12,"email":33},"Lauren Crowe, BS","319-467-7128","lauren-n-crowe@uiowa.edu",[35],{"facility":36,"status":37,"city":38,"state":39,"zip":40,"country":41,"countryCode":42,"cosmosGeoPoint":43,"geoPoint":48,"contacts":49},"University of Iowa Medical Campus - North Liberty (MCNL)","RECRUITING","North Liberty","Iowa","52713","United States","US",{"type":44,"coordinates":45},"Point",[46,47],-91.59795,41.74918,{"lat":47,"lon":46},[50,51],{"name":26,"role":27,"phone":28,"phoneExt":12,"email":29},{"name":52,"role":27,"phone":12,"phoneExt":12,"email":53},"Jason Wilken, PT, PhD","jason-wilken@uiowa.edu",{"type":55,"investigatorFullName":56,"investigatorTitle":57,"investigatorAffiliation":5,"oldNameTitle":12,"oldOrganization":12},"SPONSOR_INVESTIGATOR","Bopha Chrea","Assistant Professor","100607427","cmt-gait-mobility-balance---aofas-grant-100607427",false,"NCT07188415","CMT Gait, Mobility, Balance - AOFAS Grant","Lower Extremity Gait, Mobility and Balance Confidence in Charcot-Marie-Tooth Patients With Cavovarus Foot Deformity","Inclusion Criteria: 1) Clinical diagnosis and genetic confirmation of CMT, 2) Between the ages of 12 and 75, 3) Able to walk at a slow to moderate pace without an AFO, 3) Able to read and write in English and provide written informed consent. 4) Individuals in the NonOP group must have an AFO prescribed for daily activities. Individuals in the OP group will also have had 5) surgical correction of CMT cavovarus foot deformity focused on muscle balancing and hindfoot correction.\n\nExclusion Criteria: 1) Other causes or risk factors for peripheral neuropathy (for example diabetes, ETOH abuse), 2) Uncorrected visual impairment, 3) History of musculoskeletal injury requiring surgery 4) loss of plantar protective sensation 5) Pain \\>4\u002F10 while walking (or an increase in pain during testing of \\>2\u002F10), 6) Concern by the examiner that the individual will not complete the study. For the NonOP group 7) Previous surgical correction of CMT cavovarus foot deformity focused on muscle balancing and hindfoot correction","ALL","25 Years","55 Years",{"count":69,"type":70},66,"ESTIMATED","INTERVENTIONAL",[73],"NA","The overall objective of the proposed research is to begin to better understand the potential benefits and limitations of ankle -foot orthosis (AFO) use in the context of mobility and balance during gait for individuals with Charcot-Marie-Tooth disease (CMT). These benefits will be studied in comparison to those offered by surgical correction. We will accomplish by having subjects undergo mobility and balance tests in our gait analysis lab.",[76],"Charcot Marie Tooth Disease (CMT)",[78],"Gait Biomechanics","2025-09-17",{"date":81,"type":82},"2025-09-23","ACTUAL",{"date":84,"type":82},"2025-08-14",{"date":86,"type":70},"2027-01",{"name":56,"class":6},1]