[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100642037":3},{"organization":4,"armGroups":7,"interventions":21,"overallOfficials":48,"centralContacts":52,"locations":57,"responsibleParty":59,"collaborators":57,"id":61,"slug":62,"hasResults":63,"nctId":64,"briefTitle":65,"officialTitle":66,"acronym":57,"eligibilityCriteria":67,"healthyVolunteers":63,"sex":68,"minAge":69,"maxAge":70,"enrollmentInfo":71,"targetDuration":57,"studyType":74,"phases":75,"briefSummary":77,"conditions":78,"keywords":83,"overallStatus":88,"whyStopped":57,"lastUpdateSubmitDate":89,"lastUpdatePostDateStruct":90,"startDateStruct":93,"completionDateStruct":94,"leadSponsor":96,"locationsCount":57},{"fullName":5,"class":6},"University of California, Davis","OTHER",[8,15],{"label":9,"type":10,"description":11,"interventionNames":12},"CO₂ Laser + Triamcinolone Acetonide","ACTIVE_COMPARATOR","Participants will receive fractional ablative CO₂ laser treatment followed by laser-assisted delivery of triamcinolone acetonide to the assigned hypertrophic burn scar segment. This arm serves as the active comparator for evaluating the additional effect of 5-fluorouracil when combined with triamcinolone acetonide.",[13,14],"Device: Fractional Ablative CO₂ Laser","Drug: Triamcinolone Acetonide",{"label":16,"type":17,"description":18,"interventionNames":19},"CO₂ Laser + Triamcinolone Acetonide + 5-Fluorouracil","EXPERIMENTAL","Participants will receive fractional ablative CO₂ laser treatment followed by laser-assisted delivery of triamcinolone acetonide plus 5-fluorouracil to the assigned hypertrophic burn scar segment. This arm will evaluate whether the addition of 5-fluorouracil improves hypertrophic burn scar outcomes compared with triamcinolone acetonide alone.",[13,14,20],"Drug: Fluorouracil (5-FU)",[22,31,40],{"type":23,"name":24,"description":25,"armGroupLabels":26,"otherNames":27},"DEVICE","Fractional Ablative CO₂ Laser","Fractional ablative CO₂ laser treatment will be applied to assigned hypertrophic burn scar segments to create microthermal treatment zones and facilitate laser-assisted delivery of topical\u002Fintralesional study medication.",[9,16],[28,29,30],"CO₂ laser","Fractional carbon dioxide laser","Ablative fractional laser",{"type":32,"name":33,"description":34,"armGroupLabels":35,"otherNames":36},"DRUG","Triamcinolone Acetonide","Triamcinolone acetonide will be administered to assigned hypertrophic burn scar segments following fractional ablative CO₂ laser treatment as part of laser-assisted corticosteroid delivery.",[9,16],[37,38,39],"Kenalog","TAC","Corticosteroid",{"type":32,"name":41,"description":42,"armGroupLabels":43,"otherNames":44},"Fluorouracil (5-FU)","Fluorouracil will be administered in combination with triamcinolone acetonide to assigned hypertrophic burn scar segments following fractional ablative CO₂ laser treatment to evaluate whether adjunctive 5-fluorouracil improves scar outcomes compared with triamcinolone acetonide alone.",[16],[45,46,47],"5-FU","5-Fluorauracil","Efudex",[49],{"name":50,"affiliation":5,"role":51},"Ian A Powelson, MD","PRINCIPAL_INVESTIGATOR",[53],{"name":54,"role":55,"phone":56,"phoneExt":57,"email":58},"Arman J Fijany, MD","CONTACT","(949) 351-5830",null,"afijany@health.ucdavis.edu",{"type":60,"investigatorFullName":57,"investigatorTitle":57,"investigatorAffiliation":57,"oldNameTitle":57,"oldOrganization":57},"SPONSOR","100642037","co2-ladd-tac-with-and-without-5-fu-for-hypertrophic-burn-scars-a-triple-blinded-split-scar-rct-100642037",false,"NCT07660120","CO2 LADD TAC With and Without 5-FU for Hypertrophic Burn Scars: A Triple-Blinded, Split Scar RCT","Comparing the Safety and Efficacy of CO2 Laser-Assisted Triamcinolone Delivery With and Without 5-Fluorouracil for Hypertrophic Burn Scars: A Triple-Blinded, Randomized Split Scar Clinical Trial","Inclusion Criteria:\n\n* Patient with hypertrophic scarring secondary to burn injury\n* Ages 18-89\n\nExclusion Criteria:\n\n* Pregnant patients or patients of childbearing age, sexually active, and unwilling to utilize contraception\n* Children\n* Individuals that are cognitively impaired and unable to provide consent\n* Currently breastfeeding\n* Has taken oral retinoids within 6 months of study initiation\n* Prior laser or intralesional TAC\u002F5-FU treatments for their hypertrophic scars\n* Active infection\n* Active malignancy\n* Known hypersensitivity to CO2 laser, TAC, or 5-FU\n* Known dihydropyrimidine dehydrogenase (DPD) deficiency (complete or partial), due to risk of systemic 5-FU toxicity\n* Systemic corticosteroid or immunosuppressive medication use\n* Intolerance to anesthesia\n* Known connective tissue disease","ALL","18 Years","89 Years",{"count":72,"type":73},65,"ESTIMATED","INTERVENTIONAL",[76],"NA","Burn scars can sometimes heal in a way that causes them to become thick, raised, and stiff. These scars may itch, feel uncomfortable, limit movement, and affect how the skin looks. Because of this, many burn survivors look for treatments that can help improve both the appearance and the symptoms of their scars.\n\nOne treatment that has shown promise is fractional CO₂ laser therapy. This laser creates tiny openings in the scar tissue that help soften the scar and stimulate the skin to remodel itself. These openings can also help medications applied to the skin reach deeper into the scar where they may work better.\n\nA steroid medication called triamcinolone is commonly used to treat these scars. Another medication, called 5-fluorouracil (5-FU), has been shown in prior studies to work well when combined with steroids, but it is usually given by injection, which can be painful and sometimes causes side effects.\n\nIn this study, we will look at whether delivering these medications through the laser openings can improve scars more effectively. Each participant's scar will be divided into two halves. One side will receive both medications, and the other side will receive the steroid alone. By comparing the two sides of the same scar, we hope to better understand whether adding 5-FU provides additional benefit.",[79,80,81,82],"Burn","Hypertrophic Scars","Scar Improvement by Laser","CO2 Laser in Scars",[84,85,86,87],"burn scar","hypertrophic scar","CO2 Laser","laser assisted drug delivery","NOT_YET_RECRUITING","2026-06-29",{"date":91,"type":92},"2026-07-01","ACTUAL",{"date":91,"type":73},{"date":95,"type":73},"2028-07-10",{"name":5,"class":6}]