[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100624386":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":34,"centralContacts":35,"locations":34,"responsibleParty":41,"collaborators":34,"id":45,"slug":46,"hasResults":47,"nctId":48,"briefTitle":49,"officialTitle":50,"acronym":51,"eligibilityCriteria":52,"healthyVolunteers":47,"sex":53,"minAge":54,"maxAge":55,"enrollmentInfo":56,"targetDuration":34,"studyType":59,"phases":60,"briefSummary":62,"conditions":63,"keywords":34,"overallStatus":68,"whyStopped":34,"lastUpdateSubmitDate":69,"lastUpdatePostDateStruct":70,"startDateStruct":73,"completionDateStruct":75,"leadSponsor":77,"locationsCount":34},{"fullName":5,"class":6},"University of Calgary","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Treated breast","EXPERIMENTAL","CO2 Lift Pro® Carboxygel treated breast",[13],"Other: Carboxygel",{"label":15,"type":16,"description":17,"interventionNames":18},"Placebo breast","PLACEBO_COMPARATOR","Vaseline® control breast",[19],"Other: Vaseline",[21,27],{"type":6,"name":22,"description":23,"armGroupLabels":24,"otherNames":25},"Carboxygel","The gel will be applied to cover the entire T-junction after breast reduction surgery, once a day for 7 days.",[9],[26],"CO2 Lift Pro",{"type":6,"name":28,"description":29,"armGroupLabels":30,"otherNames":31},"Vaseline","Vaseline will be applied to the entire T-junction after breast reduction surgery once a day for 7 days",[15],[32,33],"Petroleum jelly","Petrolatum",null,[36],{"name":37,"role":38,"phone":39,"phoneExt":34,"email":40},"Merry Faye Graff, MSc","CONTACT","5876642280","merryfaye.graff1@ucalgary.ca",{"type":42,"investigatorFullName":43,"investigatorTitle":44,"investigatorAffiliation":5,"oldNameTitle":34,"oldOrganization":34},"PRINCIPAL_INVESTIGATOR","Justin Yeung","Principal Investigator","100624386","co2lift-and-t-junction-breakdown-rates-evaluation-after-breast-reduction-surgery-pilot-trial-100624386",false,"NCT07408960","CO2Lift and T-Junction Breakdown Rates Evaluation After Breast Reduction Surgery Pilot Trial","Evaluating the Effect of CO2Lift Pro® Carboxy Gel on T-Junction Breakdown Rates After Breast Reduction Surgery: A Feasibility Study","CO2-BREAST","Inclusion Criteria:\n\n* Female patients aged 18 to 85 years\n* Undergoing bilateral reduction mammoplasty using an inverted-T (Wise pattern) technique\n* American Society of Anesthesiologists (ASA) physical status classification I-III\n* Able and willing to provide informed consent\n* Willing and able to comply with study procedures and follow-up visits\n\nExclusion Criteria:\n\n* Prior radiation therapy to either breast\n* Prior breast reduction surgery to either breast\n* Known allergy or sensitivity to CO2Lift®, Vaseline®, or any of the ingredients\n* Pregnant or breastfeeding\n* History of immunosuppressive therapy\n* History of keloid formation\n* Active local or systemic infection at the time of surgery\n* Current smoker or history of substance abuse (including alcohol or illicit drugs)\n* Use of asymmetrical breast reduction techniques\n* Anticipated inability to complete follow-up or loss to follow-up","FEMALE","18 Years","85 Years",{"count":57,"type":58},10,"ESTIMATED","INTERVENTIONAL",[61],"NA","The goal of this pilot study is to determine the feasibility of a larger randomized controlled trial evaluating CO₂Lift® Pro Carboxy Gel to reduce wound breakdown after bilateral breast reduction in adult female patients undergoing elective bilateral breast reduction surgery. The main question it aims to answer is: Is it feasible to recruit, retain, and treat patients while maintaining blinding and monitoring safety?\n\nExploratory questions include: (1) Does CO₂Lift® reduce the incidence of wound breakdown compared with placebo? (2) Is CO₂Lift® safe and well-tolerated in the postoperative period?\n\nResearchers will compare CO₂Lift® applied to one breast to placebo (Vaseline®) applied to the contralateral breast to see if CO₂Lift® can improve wound healing and tissue oxygenation.\n\nParticipants will:\n\n* Undergo bilateral breast reduction surgery.\n* Receive CO₂Lift® on one breast and placebo on the other, starting immediately after surgery and daily in clinic from postoperative days 1 to 6.\n* Attend weekly postoperative follow-up visits for 12 weeks for wound assessment and monitoring of adverse events.\n* Have standardized photographs and near-infrared spectroscopy measurements taken to evaluate tissue oxygenation and healing.",[64,65,66,67],"Wound Breakdown","Breast Reduction","Surgical Wound","Breast Surgery","NOT_YET_RECRUITING","2026-02-10",{"date":71,"type":72},"2026-02-13","ACTUAL",{"date":74,"type":58},"2026-04-01",{"date":76,"type":58},"2027-12-31",{"name":5,"class":6}]