[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100614426":3},{"organization":4,"armGroups":7,"interventions":24,"overallOfficials":51,"centralContacts":55,"locations":64,"responsibleParty":92,"collaborators":94,"id":98,"slug":99,"hasResults":100,"nctId":101,"briefTitle":102,"officialTitle":102,"acronym":30,"eligibilityCriteria":103,"healthyVolunteers":104,"sex":105,"minAge":106,"maxAge":107,"enrollmentInfo":108,"targetDuration":30,"studyType":111,"phases":112,"briefSummary":114,"conditions":115,"keywords":116,"overallStatus":67,"whyStopped":30,"lastUpdateSubmitDate":119,"lastUpdatePostDateStruct":120,"startDateStruct":123,"completionDateStruct":125,"leadSponsor":127,"locationsCount":128},{"fullName":5,"class":6},"NYU Langone Health","OTHER",[8,19],{"label":9,"type":10,"description":11,"interventionNames":12},"Cochlear Implant Users","EXPERIMENTAL","Postlingually deaf adults (age 18-80) with at least one year of CI experience. Participants will complete behavioral speech perception and comprehension tasks with pupillometry measurement.",[13,14,15,16,17,18],"Behavioral: Experiment 1: Syntactic and Semantic Context","Behavioral: Experiment 2: False Hearing and Context Overuse","Behavioral: Experiment 3: Two-Sentence Problem","Behavioral: Experiment 4: Cascading Effects on Discourse Comprehension","Behavioral: Experiment 5: Self-Paced Discourse Comprehension","Behavioral: Experiment 6: Clinical Application",{"label":20,"type":21,"description":22,"interventionNames":23},"Normal-Hearing Controls (Vocoder Simulation)","ACTIVE_COMPARATOR","Normal-hearing adults (age 18-80) listening to degraded speech via 4- and 8-channel vocoders. Participants will complete the same behavioral tasks as CI users but with (or without) acoustically degraded speech simulation.",[13,14,15,16,17,18],[25,31,35,39,43,47],{"type":26,"name":27,"description":28,"armGroupLabels":29,"otherNames":30},"BEHAVIORAL","Experiment 1: Syntactic and Semantic Context","* Recall of meaningful sentences, anomalous word strings, and unstructured word lists\n* Measurement of syntactic and semantic gain\n* Pupillometry during auditory and visual presentation",[9,20],null,{"type":26,"name":32,"description":33,"armGroupLabels":34,"otherNames":30},"Experiment 2: False Hearing and Context Overuse","* Two-choice word recognition task with semantic priming\u002Fluring in multi-talker babble\n* Three Signal-to-Noise Ratio (SNR) levels (heavy, medium, light noise)\n* Confidence ratings for responses\n* Pupillometry measurement",[9,20],{"type":26,"name":36,"description":37,"armGroupLabels":38,"otherNames":30},"Experiment 3: Two-Sentence Problem","* Speech recognition and recall of single sentences vs. paired sentences\n* Manipulation of inter-sentence semantic predictability (high vs. low)\n* Four test conditions: 1-sentence, 2-sentences, 2-sentences+pre-prompt, 2-sentences+post-prompt\n* Pupillometry during task",[9,20],{"type":26,"name":40,"description":41,"armGroupLabels":42,"otherNames":30},"Experiment 4: Cascading Effects on Discourse Comprehension","* Recall of 27 narrative passages (67-97 words each)\n* Propositional analysis scoring (main ideas, mid-level ideas, details)\n* Measurement of semantic hierarchy effect\n* Pupillometry during listening",[9,20],{"type":26,"name":44,"description":45,"armGroupLabels":46,"otherNames":30},"Experiment 5: Self-Paced Discourse Comprehension","* 24 discourse passages (150 words each): 12 narrative, 12 expository\n* Continuous presentation vs. self-paced presentation (stops at clause\u002Fsentence boundaries)\n* Measurement of pause times and comprehension recall\n* Pupillometry during task",[9,20],{"type":26,"name":48,"description":49,"armGroupLabels":50,"otherNames":30},"Experiment 6: Clinical Application","* Self-Paced Sentence Comprehension\n* Sentences with varying syntactic complexity (active-conjoined, subject-relative, object-relative)\n* Continuous vs. self-paced (with pause at major clause boundary) presentation\n* True\u002Ffalse comprehension verification statements\n* Pupillometry measurement",[9,20],[52],{"name":53,"affiliation":5,"role":54},"Mario A. Svirsky, PhD","PRINCIPAL_INVESTIGATOR",[56,60],{"name":53,"role":57,"phone":58,"phoneExt":30,"email":59},"CONTACT","212-263-7217","Mario.svirsky@nyulangone.org",{"name":61,"role":57,"phone":62,"phoneExt":30,"email":63},"Nicole Capach","646-501-6905","Nicole.capach@nyulangone.org",[65,82],{"facility":66,"status":67,"city":68,"state":69,"zip":70,"country":71,"countryCode":72,"cosmosGeoPoint":73,"geoPoint":78,"contacts":79},"Brandeis University","RECRUITING","Waltham","Massachusetts","02453","United States","US",{"type":74,"coordinates":75},"Point",[76,77],-71.23561,42.37649,{"lat":77,"lon":76},[80],{"name":81,"role":54,"phone":30,"phoneExt":30,"email":30},"Arthur Wingfield",{"facility":5,"status":67,"city":83,"state":83,"zip":84,"country":71,"countryCode":72,"cosmosGeoPoint":85,"geoPoint":89,"contacts":90},"New York","10016",{"type":74,"coordinates":86},[87,88],-74.00597,40.71427,{"lat":88,"lon":87},[91],{"name":53,"role":54,"phone":30,"phoneExt":30,"email":30},{"type":93,"investigatorFullName":30,"investigatorTitle":30,"investigatorAffiliation":30,"oldNameTitle":30,"oldOrganization":30},"SPONSOR",[95],{"name":96,"class":97},"National Institute on Deafness and Other Communication Disorders (NIDCD)","NIH","100614426","cochlear-implants-and-listening-effort-the-interaction-of-cognitive-and-sensory-constraints-100614426",false,"NCT07279441","Cochlear Implants and Listening Effort: the Interaction of Cognitive and Sensory Constraints","Inclusion Criteria:\n\n* Subjects will be otherwise healthy normal-hearing and cochlear implant (CI) adult listeners (between 18 and 80 years old).\n\nExclusion Criteria:\n\n* Individuals below 18 years of age.\n* Individuals with evidence of neurologic, vascular or psychiatric disease or dementia, and taking medications that might interfere with task performance.\n* Individuals with a history of language disorders (besides those associated with hearing loss for the CI users). Individuals who are non-native speakers of American English.",true,"ALL","18 Years","80 Years",{"count":109,"type":110},460,"ESTIMATED","INTERVENTIONAL",[113],"NA","This study examines how cochlear implant users understand and comprehend speech in realistic communication situations. Through six experiments measuring listening effort via pupillometry and discourse comprehension, we will investigate how linguistic context, cognitive demands, and processing time affect speech understanding in CI users, and in normal-hearing controls) to identify factors underlying communication resilience versus vulnerability and develop improved, ecologically valid assessment and rehabilitation strategies.",[9],[117,118],"CI","Cochlear implant","2025-12-09",{"date":121,"type":122},"2025-12-12","ACTUAL",{"date":124,"type":122},"2025-01-02",{"date":126,"type":110},"2030-01-02",{"name":5,"class":6},2]