[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100554138":3},{"organization":4,"armGroups":7,"interventions":30,"overallOfficials":51,"centralContacts":56,"locations":65,"responsibleParty":87,"collaborators":36,"id":89,"slug":90,"hasResults":91,"nctId":92,"briefTitle":93,"officialTitle":94,"acronym":36,"eligibilityCriteria":95,"healthyVolunteers":96,"sex":97,"minAge":98,"maxAge":99,"enrollmentInfo":100,"targetDuration":36,"studyType":103,"phases":104,"briefSummary":106,"conditions":107,"keywords":109,"overallStatus":68,"whyStopped":36,"lastUpdateSubmitDate":114,"lastUpdatePostDateStruct":115,"startDateStruct":118,"completionDateStruct":120,"leadSponsor":122,"locationsCount":123},{"fullName":5,"class":6},"Appalachian State University","OTHER",[8,15,20,26],{"label":9,"type":10,"description":11,"interventionNames":12},"Blueberry + walking","EXPERIMENTAL","Blueberry intake combined with walking exercise.",[13,14],"Dietary Supplement: Blueberry","Behavioral: Walking",{"label":16,"type":10,"description":17,"interventionNames":18},"Blueberry + stretching","Blueberry intake combined with stretching exercise.",[13,19],"Behavioral: Stretching",{"label":21,"type":22,"description":23,"interventionNames":24},"Placebo + walking","ACTIVE_COMPARATOR","Placebo intake combined with walking exercise.",[14,25],"Dietary Supplement: Placebo",{"label":27,"type":22,"description":28,"interventionNames":29},"Placebo + stretching","Placebo intake combined with stretching exercise.",[25,19],[31,37,44,48],{"type":32,"name":33,"description":34,"armGroupLabels":35,"otherNames":36},"DIETARY_SUPPLEMENT","Blueberry","50 g\u002Fd blueberry powder supplement",[16,9],null,{"type":38,"name":39,"description":40,"armGroupLabels":41,"otherNames":42},"BEHAVIORAL","Walking","Five 45-min walking sessions per week",[9,21],[43],"Stretching",{"type":32,"name":45,"description":46,"armGroupLabels":47,"otherNames":36},"Placebo","50 g\u002Fd placebo powder supplement",[27,21],{"type":38,"name":43,"description":49,"armGroupLabels":50,"otherNames":36},"Five 45-min stretching sessions per week",[16,27],[52],{"name":53,"affiliation":54,"role":55},"David C Nieman, DrPH","Appalachian State Univ","PRINCIPAL_INVESTIGATOR",[57,61],{"name":53,"role":58,"phone":59,"phoneExt":36,"email":60},"CONTACT","8287730056","niemandc@appstate.edu",{"name":62,"role":58,"phone":63,"phoneExt":36,"email":64},"Camila A Olson, PhD","7042505352","olsonca1@appstate.edu",[66],{"facility":67,"status":68,"city":69,"state":70,"zip":71,"country":72,"countryCode":73,"cosmosGeoPoint":74,"geoPoint":79,"contacts":80},"Appalachian State University Human Performance Lab, North Carolina Research Campus","RECRUITING","Kannapolis","North Carolina","28081","United States","US",{"type":75,"coordinates":76},"Point",[77,78],-80.62173,35.48736,{"lat":78,"lon":77},[81,84,86],{"name":82,"role":58,"phone":83,"phoneExt":36,"email":60},"David Nieman, DrPH","828-773-0056",{"name":85,"role":58,"phone":63,"phoneExt":36,"email":64},"Camila A Sakaguchi, PhD",{"name":82,"role":55,"phone":36,"phoneExt":36,"email":36},{"type":88,"investigatorFullName":36,"investigatorTitle":36,"investigatorAffiliation":36,"oldNameTitle":36,"oldOrganization":36},"SPONSOR","100554138","cognition-flavonoids-exercise-gut-microbiome-100554138",false,"NCT06495190","Cognition, Flavonoids, Exercise, Gut Microbiome","Age-related Cognitive Changes: Effects of Combined Flavonoid Intake and Physical Exertion Mediated by the Gut Microbiome","Inclusion Criteria:\n\n* Score on the Montreal Cognitive Assessment (MoCA test) of 24.1-25.2 that indicates mild cognitive decline. The MoCA test score ranges from 0 to 30, with higher scores from 26 to 30 considered normal.\n* Healthy, non-smoking male or female participants 65 to 85 years of age.\n* Capable of engaging in a supervised 12-week exercise training program (brisk walking or stretching).\n* Physically inactive (defined as less than 150 min\u002Fweek moderate or less than 75 minutes vigorous aerobic and\u002For resistance exercise during the past 4 weeks).\n* Willingness to be randomized to one of four groups.\n* Willingness to provide blood, urine, and fecal samples (3 each),\n* Willingness to avoid blueberry intake during the 12-weeks study (other than what is provided through the study).\n* Willingness to maintain current diet and physical activity patterns during the study (other than what is prescribed as a part of the study), and make no formal attempts to lose or gain body weight.\n* Willingness to be a participant in this study only and not enter any other studies.\n\nExclusion Criteria:\n\n* Allergy to blueberries.\n* Diagnosis of Type I or Type 2 diabetes.\n* Chronic cardiovascular, metabolic, or renal condition that is uncontrolled (controlled defined as stable for 6 months or more).\n* History of signs or symptoms during rest or physical activity such as chest discomfort, unreasonable breathlessness, dizziness, fainting, or blackouts.\n* Use of any prescription or over-the-counter drug intended to support cognition or with known cognitive side effects.\n* Any other concurrent condition or use of medications or supplements which, in the opinion of the study clinician would preclude participation in this study.\n* Diagnosis of dementia.",true,"ALL","65 Years","85 Years",{"count":101,"type":102},240,"ESTIMATED","INTERVENTIONAL",[105],"NA","This NIH project will examine the effects of routine flavonoid-rich blueberry intake (12-weeks), combined with or in the absence of regular moderate exercise, on cognitive function in a clinical population of older participants identified as experiencing age-related cognitive changes. This project's hypothesis is that the combination of flavonoid-rich diet and routine physical activity may potentiate cognitive benefits and reduce cognitive decline in an aging population, via mechanisms mediated by the gut microbiome.",[108],"Cognitive Decline, Mild",[110,111,112,113],"aging","flavonoids","exercise","gut microbiome","2025-03-07",{"date":116,"type":117},"2025-03-12","ACTUAL",{"date":119,"type":117},"2025-01-01",{"date":121,"type":102},"2028-12-31",{"name":5,"class":6},1]