[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100584157":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":24,"centralContacts":29,"locations":18,"responsibleParty":37,"collaborators":18,"id":40,"slug":41,"hasResults":42,"nctId":43,"briefTitle":44,"officialTitle":45,"acronym":46,"eligibilityCriteria":47,"healthyVolunteers":42,"sex":48,"minAge":49,"maxAge":50,"enrollmentInfo":51,"targetDuration":18,"studyType":54,"phases":55,"briefSummary":57,"conditions":58,"keywords":18,"overallStatus":61,"whyStopped":18,"lastUpdateSubmitDate":62,"lastUpdatePostDateStruct":63,"startDateStruct":66,"completionDateStruct":68,"leadSponsor":70,"locationsCount":18},{"fullName":5,"class":6},"Boston Children's Hospital","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Cognitive Control Training + Metacognition Coaching","EXPERIMENTAL","Intervention will be delivered individually in person. Cognitive Control (CC) Computer Training consists of four games that require multiple aspects of CC (flexible thinking, inhibitory control) and working memory. Each game has approximately 20 levels of increasing difficulty. Parameters that contribute to the difficulty and passing criteria are fixed, but children progress from level to level at their own pace. Metacognition Coaching employs manualized strategies that: meaningfully engage children with the training tasks; simplify tasks to make them more manageable; support sustained effort; emphasize key CC skills needed for tasks; provide coping strategies to reduce frustration associated with challenging aspects of the games; and use guided conversations to aid children with mastering each game. To support the needs of children with ASD, key concepts are described using consistent language and visual supports throughout training sessions.",[13],"Behavioral: Cognitive Control Training + Metacognition Coaching",{"label":15,"type":16,"description":17,"interventionNames":18},"Waitlist","NO_INTERVENTION","The waitlist group will continue with any ongoing interventions (treatment as usual) and will not initially receive the training program. At the end of the study, the waitlist group will be offered training.",null,[20],{"type":21,"name":9,"description":22,"armGroupLabels":23,"otherNames":18},"BEHAVIORAL","Computer training is delivered in person by a coach. Training consists of four games; each requires multiple aspects of cognitive control. Training levels progress in difficulty by increasing the number of items or simultaneous dimensions, decreasing the available response time, requiring greater accuracy, or adjusting the proportion of distractors or their complexity. Parameters that influence the difficulty of each level and passing criteria are fixed, but children progress from level to level at their own pace. Training is accompanied by manualized metacognition coaching to provide strategies to meaningfully engage with the tasks, simplify the tasks, support sustained effort, emphasize key cognitive control skills needed, provide coping strategies to reduce frustration associated with challenging aspects of the games, and use guided conversations to highlight metacognition.",[9],[25],{"name":26,"affiliation":27,"role":28},"Susan Faja, PhD","Boston Children's Hospital \u002F Harvard Medical School","PRINCIPAL_INVESTIGATOR",[30,34],{"name":26,"role":31,"phone":32,"phoneExt":18,"email":33},"CONTACT","6179194486","susan.faja@childrens.harvard.edu",{"name":35,"role":31,"phone":36,"phoneExt":18,"email":18},"Doo-yun Her","617-919-4108",{"type":28,"investigatorFullName":38,"investigatorTitle":39,"investigatorAffiliation":5,"oldNameTitle":18,"oldOrganization":18},"Susan Faja","Associate Professor, Scientist","100584157","cognitive-control-and-metacognition-training-100584157",false,"NCT06885684","Cognitive Control and Metacognition Training","Developing Cognitive Control and Metacognition to Reduce the Functional Impact of Restricted and Repetitive Behaviors in Autism","CoMeT","Inclusion Criteria:\n\n* Children should be 8 to 11 years of age\n* Children should have an existing diagnosis of an autism spectrum disorder, which will be confirmed using research measures and criteria\n* Children must have general cognitive ability in the average range or above (above 80 using the Wechsler Abbreviated Scale of Intelligence-2 Full Scale IQ)\n* Caregivers and children must be fluent in English or Spanish\n\nExclusion Criteria:\n\n* Children must not have a known genetic condition related to autism (e.g., Fragile X)\n* Children must not have medical conditions\u002Finjuries, exposure to substances, or significant deprivation with implications for the central nervous system or that require regular psychoactive medications that alter EEG responses (anticonvulsants, barbiturates) \\*\n* Children must not have seizures or a seizure disorder (other than history of febrile seizures)\n* Children must not have significant sensory or motor impairment or major physical abnormalities that would limit the ability to participate in table top or EEG testing, or make responding during computer activities difficult\n* Children must not have a failed screening for colorblindness","ALL","8 Years","11 Years",{"count":52,"type":53},95,"ESTIMATED","INTERVENTIONAL",[56],"NA","95 autistic children (ages 8-11yrs) will be randomly assigned to a novel computer-based Cognitive Control Training combined with Metacognition Coaching or to a comparison group that receives the intervention after a delay. Before and after intervention, electroencephalography (EEG) will be used to examine engagement of the target neural responses.",[59,60],"Autism","Autism Spectrum Disorder","NOT_YET_RECRUITING","2026-04-22",{"date":64,"type":65},"2026-04-27","ACTUAL",{"date":67,"type":53},"2026-06-30",{"date":69,"type":53},"2028-06-30",{"name":5,"class":6}]