[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100605289":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":31,"centralContacts":35,"locations":41,"responsibleParty":57,"collaborators":39,"id":60,"slug":61,"hasResults":62,"nctId":63,"briefTitle":64,"officialTitle":65,"acronym":39,"eligibilityCriteria":66,"healthyVolunteers":67,"sex":68,"minAge":69,"maxAge":70,"enrollmentInfo":71,"targetDuration":39,"studyType":74,"phases":75,"briefSummary":77,"conditions":78,"keywords":81,"overallStatus":85,"whyStopped":39,"lastUpdateSubmitDate":86,"lastUpdatePostDateStruct":87,"startDateStruct":90,"completionDateStruct":92,"leadSponsor":94,"locationsCount":95},{"fullName":5,"class":6},"University of Illinois at Chicago","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Novel CogXergaming Training","EXPERIMENTAL","Customized Novel CogXergaming Training based on cognitive-motor balance training will be delivered to Participants in group A. Participants will undergo 18 sessions of training for eight weeks, with around 60 minutes of training per session, i.e., 3 sessions per week in the first 2 weeks, and 2 sessions per week in the remaining 6 weeks. All the CXT training will be performed using a desktop with a webcam.",[13],"Behavioral: Novel CogXergaming Training",{"label":15,"type":10,"description":16,"interventionNames":17},"Exercise and Education Training Program","Participants in Group B will complete 8 weeks of a conventional exercise program and fall-prevention education (3x\u002Fweek in the first 2 weeks and 2x\u002Fweek in the remaining 6 weeks, 18 sessions total) in the lab.",[18],"Behavioral: Exercise and Education Training Program",[20,26],{"type":21,"name":9,"description":22,"armGroupLabels":23,"otherNames":24},"BEHAVIORAL","In each session, participants will play 6 games in the same order (Fruit catch, Math, Tracking, Candy match, Letter Number Sequencing - LNS, Stroop), each of which contains 10-20 trials and will last for around 10 minutes (total = 60 minutes. The CXT program employs a progressive method to ensure the intensity of CXT remains challenging without overload. If a participant demonstrates ≥80% accuracy in 3 continuous trials for one game, then the exercises for this game will be progressed to the next level (levels: 1-9 in Table 3). Each session of CXT will last approximately 1 hour. At least one day of rest will be required between weekly training sessions.",[9],[25],"CXT",{"type":21,"name":15,"description":27,"armGroupLabels":28,"otherNames":29},"EEP consists of a conventional exercise program and fall-prevention education. The conventional exercise program comprises 50 minutes of supervised exercises for stretching and strengthening. A fall-prevention education program will also be provided to Group B, for about 10 minutes after each session of the exercise program. Each session of EEP will last approximately 1 hour. At least one day of rest will be required between weekly training sessions.",[15],[30],"EEP",[32],{"name":33,"affiliation":5,"role":34},"Shuaijie Wang, PhD","PRINCIPAL_INVESTIGATOR",[36],{"name":33,"role":37,"phone":38,"phoneExt":39,"email":40},"CONTACT","3123554674",null,"sjwang4@uic.edu",[42],{"facility":5,"status":39,"city":43,"state":44,"zip":45,"country":46,"countryCode":47,"cosmosGeoPoint":48,"geoPoint":53,"contacts":54},"Chicago","Illinois","60612","United States","US",{"type":49,"coordinates":50},"Point",[51,52],-87.65005,41.85003,{"lat":52,"lon":51},[55],{"name":56,"role":37,"phone":38,"phoneExt":39,"email":40},"Shuaijie Wang",{"type":34,"investigatorFullName":58,"investigatorTitle":59,"investigatorAffiliation":5,"oldNameTitle":39,"oldOrganization":39},"Wang Shuaijie","Research Associate Professor","100605289","cognitive-motor-training-for-adadrd-prevention-100605289",false,"NCT07160582","Cognitive-Motor Training for AD\u002FADRD Prevention","Innovative Cognitive-Motor Training for Prevention of AD\u002FADRD","Inclusion Criteria:\n\n1. Age: 55-90 years.\n2. No recent major surgery, bone fracture, or hospitalization (\\\u003C 3 months).\n3. Not on any sedative drugs.\n4. Can understand and communicate in English.\n5. Can walk without an assistive device for at least 1 block to ensure independent functioning.\n6. Identification of Mild Cognitive Impairment (MCI) based on Jak\u002FBondi criteria\n7. Visual acuity greater than or equal to 20\u002F40 with or without corrective lenses to ensure intact vision.\n\nExclusion Criteria:\n\n1. Participants will not proceed with the study if any of the following occurs at baseline measurement: 1) Heart Rate \\>85% of age-predicted maximal heart rate (HRmax) (HRmax = 220 - age), 2) systolic blood pressure (SBP) \\> 160 mmHg and\u002For diastolic blood pressure (DBP) \\> 110 mmHg during resting.\n2. Unable to stand for 5 minutes without an assistive device and walk for 10 m without an assistive device\n3. Complaints of shortness of breath, or uncontrolled pain (more than 3 out of 10 on Visual Analogue Scale), or if pulse oxygen drops less than 92% on the six-minute walk test (for endurance) to ensure that the participant can effectively participate without discomfort or injury during testing and training.\n4. Exhibits difficulty understanding the study information.\n5. Self-reported history or presence of any neurological, musculoskeletal, cardiorespiratory, or systemic disorders that significantly impact mobility or the ability to walk independently (without an assistive device).\n6. Self-reported disability (with or without an assistive device) to ensure independent functioning.\n7. Uncontrolled (not under any medications) hypertension to avoid cardiovascular complications during testing\u002Ftraining.\n8. Weight \\>220 lbs (harness weight threshold).",true,"ALL","55 Years","90 Years",{"count":72,"type":73},46,"ESTIMATED","INTERVENTIONAL",[76],"NA","Alzheimer's disease and related dementias (AD\u002FADRD) greatly affect memory and daily activities in older adults. Mild Cognitive Impairment (MCI) is an early stage of dementia, affecting about 17% of older adults. People with MCI often show problems with gait and balance, which doubles their risk of falling compared to cognitively healthy peers. Falls can cause injuries, increase sedentary behavior, and reduce physical activity. This decline in activity can also speed up the progression from MCI to dementia. Exercise can help older adults make healthy lifestyle changes; however, most of the existing exercise programs focus mainly on physical movement rather than cognitive function. Therefore, the investigators developed a new program that uses computer vision and a cloud-based system to provide more scalable, engaging, and personalized cognitive-motor training for OAwMCI. The purpose of this study is to investigate the short- and long-term effects of a novel CogXergaming training (CXT) paradigm for improving the cognitive-motor function, physical activity, falls efficacy, and quality of life.",[79,80],"MCI","Aging",[82,83,84],"CogXergaming","Cognitive-motor interference","Dual-task","NOT_YET_RECRUITING","2026-03-19",{"date":88,"type":89},"2026-03-24","ACTUAL",{"date":91,"type":73},"2026-05-01",{"date":93,"type":73},"2027-09-01",{"name":5,"class":6},1]