[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100588054":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":25,"centralContacts":37,"locations":46,"responsibleParty":67,"collaborators":70,"id":75,"slug":76,"hasResults":77,"nctId":78,"briefTitle":79,"officialTitle":80,"acronym":81,"eligibilityCriteria":82,"healthyVolunteers":83,"sex":84,"minAge":85,"maxAge":86,"enrollmentInfo":87,"targetDuration":18,"studyType":90,"phases":91,"briefSummary":93,"conditions":94,"keywords":98,"overallStatus":48,"whyStopped":18,"lastUpdateSubmitDate":108,"lastUpdatePostDateStruct":109,"startDateStruct":112,"completionDateStruct":114,"leadSponsor":116,"locationsCount":117},{"fullName":5,"class":6},"Beykoz University","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"CRT Group","EXPERIMENTAL","Participants with schizophrenia assigned to receive 12 sessions of Cognitive Remediation Therapy (CRT) over 12 weeks. Each session lasts approximately 60 minutes and targets cognitive domains including attention, working memory, executive function, and emotion regulation.",[13],"Behavioral: Cognitive Remediation Therapy",{"label":15,"type":16,"description":17,"interventionNames":18},"Waitlist Control","NO_INTERVENTION","Participants with schizophrenia assigned to a waitlist control group. They will not receive any therapy during the 12-week period but will undergo baseline and post-assessments similar to the CRT group.",null,[20],{"type":21,"name":22,"description":23,"armGroupLabels":24,"otherNames":18},"BEHAVIORAL","Cognitive Remediation Therapy","CRT is a structured behavioral intervention consisting of weekly 60-minute sessions for 12 weeks. The therapy includes tasks to enhance cognitive skills such as attention, memory, executive function, and emotional regulation using computer-based training and therapist-guided exercises.",[9],[26,30,33],{"name":27,"affiliation":28,"role":29},"Gökben Hızlı Sayar, Professor","Üsküdar University","STUDY_CHAIR",{"name":31,"affiliation":28,"role":32},"Selami Varol Ülker, Phd","STUDY_DIRECTOR",{"name":34,"affiliation":35,"role":36},"Metin Çınaroğlu, Phd","İstanbul Nişantaşı University","PRINCIPAL_INVESTIGATOR",[38,43],{"name":39,"role":40,"phone":41,"phoneExt":18,"email":42},"Eda Yılmazer, Phd","CONTACT","00905322575880","edayilmazer@beykoz.edu.tr",{"name":34,"role":40,"phone":44,"phoneExt":18,"email":45},"00905324732070","metincinaroglu@gmail.com",[47],{"facility":5,"status":48,"city":49,"state":18,"zip":50,"country":51,"countryCode":18,"cosmosGeoPoint":52,"geoPoint":57,"contacts":58},"RECRUITING","Istanbul","34820","Turkey (Türkiye)",{"type":53,"coordinates":54},"Point",[55,56],28.94966,41.01384,{"lat":56,"lon":55},[59,60,63,64,66],{"name":39,"role":40,"phone":41,"phoneExt":18,"email":42},{"name":31,"role":40,"phone":61,"phoneExt":18,"email":62},"00905364360941","selamivarol.ulker@uskudar.edu.tr",{"name":27,"role":36,"phone":18,"phoneExt":18,"email":18},{"name":31,"role":65,"phone":18,"phoneExt":18,"email":18},"SUB_INVESTIGATOR",{"name":34,"role":65,"phone":18,"phoneExt":18,"email":18},{"type":36,"investigatorFullName":68,"investigatorTitle":69,"investigatorAffiliation":5,"oldNameTitle":18,"oldOrganization":18},"Eda Yilmazer","Principle investigator",[71,73],{"name":72,"class":6},"Uskudar University",{"name":74,"class":6},"Istanbul Nisantasi University","100588054","cognitive-remediation-therapy-for-schizophrenia-effects-on-eeg-and-emotional-regulation-100588054",false,"NCT06936397","Cognitive Remediation Therapy for Schizophrenia: Effects on EEG and Emotional Regulation","A Randomized Controlled EEG-GSR Study on the Effects of Cognitive Remediation Therapy on Neurophysiological and Emotional Regulation Markers in Schizophrenia","CRT-SCHZ","Inclusion Criteria (Schizophrenia Group):\n\n* Diagnosed with schizophrenia according to DSM-5 criteria\n* Age between 18 and 55 years\n* Clinically stable (no hospitalization or medication change within 1 month)\n* Minimum primary school education\n* Able to provide informed consent\n* Right-handed (for EEG protocol consistency)\n\nInclusion Criteria (Healthy Control Group):\n\n* No history of psychiatric or neurological disorders\n* Age- and gender-matched to schizophrenia group\n* No current medication affecting CNS\n* Able to provide informed consent\n* Right-handed\n\nExclusion Criteria (Both Groups):\n\n* Current or past substance use disorder (within the past year)\n* Comorbid neurological illness (e.g., epilepsy, traumatic brain injury)\n* Current use of benzodiazepines or medications that significantly affect cognitive function\n* Intellectual disability or MoCA score \\\u003C 20\n* Visual or hearing impairments that could interfere with task performance\n* Participation in a psychological intervention in the last 3 months",true,"ALL","18 Years","55 Years",{"count":88,"type":89},60,"ESTIMATED","INTERVENTIONAL",[92],"NA","This study aims to determine whether Cognitive Remediation Therapy (CRT) can improve attention, memory, and emotional regulation in people with schizophrenia. CRT is a structured program that includes exercises to strengthen cognitive skills such as problem-solving, working memory, and emotion regulation.\n\nThe study will recruit 60 participants: 30 individuals with schizophrenia and 30 healthy individuals of similar age and gender. Those with schizophrenia will be randomly assigned to either receive CRT or be placed on a waitlist without therapy. All participants will undergo non-invasive brain activity (EEG) and emotional response (GSR) recordings before and after the therapy.\n\nThe study's main question is: Does participating in a 12-week CRT program improve brain-based markers of attention and emotional regulation in people with schizophrenia?\n\nAdditional tests, such as memory and emotion recognition tasks and self-report questionnaires, will help assess changes in thinking skills and emotional well-being. The study may help better understand how CRT affects both brain function and quality of life in schizophrenia.",[95,96,97],"Schizophrenia Disorders","Cognitive Dysfunction","Emotion Regulation Disorders",[22,99,100,101,102,103,104,105,106,107],"Schizophrenia","EEG","GSR","Emotion Regulation","Executive Function","P300","Mismatch Negativity","Neurophysiological Biomarkers","Psychophysiology","2025-04-13",{"date":110,"type":111},"2025-04-20","ACTUAL",{"date":113,"type":111},"2025-03-15",{"date":115,"type":89},"2025-10-15",{"name":5,"class":6},1]