[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100613478":3},{"organization":4,"armGroups":7,"interventions":7,"overallOfficials":7,"centralContacts":7,"locations":8,"responsibleParty":223,"collaborators":225,"id":243,"slug":244,"hasResults":245,"nctId":246,"briefTitle":247,"officialTitle":248,"acronym":249,"eligibilityCriteria":250,"healthyVolunteers":245,"sex":251,"minAge":252,"maxAge":7,"enrollmentInfo":253,"targetDuration":7,"studyType":256,"phases":7,"briefSummary":257,"conditions":258,"keywords":273,"overallStatus":11,"whyStopped":7,"lastUpdateSubmitDate":276,"lastUpdatePostDateStruct":277,"startDateStruct":280,"completionDateStruct":282,"leadSponsor":284,"locationsCount":285},{"fullName":5,"class":6},"Second Affiliated Hospital, School of Medicine, Zhejiang University","OTHER",null,[9,28,43,58,68,83,98,113,127,142,157,172,185,195,209],{"facility":10,"status":11,"city":12,"state":13,"zip":7,"country":14,"countryCode":15,"cosmosGeoPoint":16,"geoPoint":21,"contacts":22},"Fujian Provincial Hospital, Affiliated to Fuzhou University","RECRUITING","Fuzhou","Fujian","China","CN",{"type":17,"coordinates":18},"Point",[19,20],119.30611,26.06139,{"lat":20,"lon":19},[23],{"name":24,"role":25,"phone":26,"phoneExt":7,"email":27},"Xinjing Chen, PhD","CONTACT","+86-13405927173","3319326@163.com",{"facility":29,"status":11,"city":30,"state":31,"zip":32,"country":14,"countryCode":15,"cosmosGeoPoint":33,"geoPoint":37,"contacts":38},"Renmin Hospital of Wuhan University","Wuhan","Hubei","430060",{"type":17,"coordinates":34},[35,36],114.26667,30.58333,{"lat":36,"lon":35},[39],{"name":40,"role":25,"phone":41,"phoneExt":7,"email":42},"Jing Chen, 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Command","Shenyang","Liaoning","110031",{"type":17,"coordinates":74},[75,76],123.43278,41.79222,{"lat":76,"lon":75},[79],{"name":80,"role":25,"phone":81,"phoneExt":7,"email":82},"Yang Li","+86 15309889820","liyang19830925@126.com",{"facility":84,"status":11,"city":85,"state":86,"zip":87,"country":14,"countryCode":15,"cosmosGeoPoint":88,"geoPoint":92,"contacts":93},"The First Affiliated Hospital of Air Force Medicial University","Xi'an","Shaanxi","710032",{"type":17,"coordinates":89},[90,91],108.92861,34.25833,{"lat":91,"lon":90},[94],{"name":95,"role":25,"phone":96,"phoneExt":7,"email":97},"Rutao Wang, Doctor","+86 15091095796","rutaowang@qq.com",{"facility":99,"status":11,"city":100,"state":101,"zip":102,"country":14,"countryCode":15,"cosmosGeoPoint":103,"geoPoint":107,"contacts":108},"Affiliated Hospital of Qingdao University","Qingdao","Shandong","266000",{"type":17,"coordinates":104},[105,106],120.38042,36.06488,{"lat":106,"lon":105},[109],{"name":110,"role":25,"phone":111,"phoneExt":7,"email":112},"Weili Liu","+86-18661800557","liuweili2008@yeah.net",{"facility":114,"status":11,"city":115,"state":116,"zip":7,"country":14,"countryCode":15,"cosmosGeoPoint":117,"geoPoint":121,"contacts":122},"Huaxi Hospital","Chengdu","Sichuan",{"type":17,"coordinates":118},[119,120],104.06667,30.66667,{"lat":120,"lon":119},[123],{"name":124,"role":25,"phone":125,"phoneExt":7,"email":126},"Jun Shi, Doctor","+96-18608013976","shijun@wchscu.cn",{"facility":128,"status":11,"city":129,"state":130,"zip":131,"country":14,"countryCode":15,"cosmosGeoPoint":132,"geoPoint":136,"contacts":137},"People's Hospital of Xinjiang Uygur Autonomous Region","Ürümqi","Xinjiang","830000",{"type":17,"coordinates":133},[134,135],87.60046,43.80096,{"lat":135,"lon":134},[138],{"name":139,"role":25,"phone":140,"phoneExt":7,"email":141},"Xiangyu Dong","+86 18199738873","960446978@qq.com",{"facility":143,"status":11,"city":144,"state":145,"zip":146,"country":14,"countryCode":15,"cosmosGeoPoint":147,"geoPoint":151,"contacts":152},"Fuwai Yunnan Cardiovascular Hospital","Kunming","Yunnan","650032",{"type":17,"coordinates":148},[149,150],102.71833,25.03889,{"lat":150,"lon":149},[153],{"name":154,"role":25,"phone":155,"phoneExt":7,"email":156},"Da Zhu, PhD","+86-17780731330","zhuda8687@126.com",{"facility":158,"status":11,"city":159,"state":160,"zip":161,"country":14,"countryCode":15,"cosmosGeoPoint":162,"geoPoint":166,"contacts":167},"Second Affiliated Hospital of Zhejiang University, School of Medicine","Hangzhou","Zhejiang","310000",{"type":17,"coordinates":163},[164,165],120.16142,30.29365,{"lat":165,"lon":164},[168],{"name":169,"role":25,"phone":170,"phoneExt":7,"email":171},"Xianbao Liu, Doctor","+86-0571-87788625","liuxb@zju.edu.cn",{"facility":173,"status":11,"city":174,"state":7,"zip":7,"country":14,"countryCode":15,"cosmosGeoPoint":175,"geoPoint":179,"contacts":180},"Chinese Academy of Medical Sciences, Fuwai Hospital","Beijing",{"type":17,"coordinates":176},[177,178],116.39723,39.9075,{"lat":178,"lon":177},[181],{"name":182,"role":25,"phone":183,"phoneExt":7,"email":184},"Guangzhi Zhao","+86 18910290918","guangzhilala@sina.com",{"facility":186,"status":11,"city":174,"state":7,"zip":7,"country":14,"countryCode":15,"cosmosGeoPoint":187,"geoPoint":189,"contacts":190},"Navy General Hospital, Beijing",{"type":17,"coordinates":188},[177,178],{"lat":178,"lon":177},[191],{"name":192,"role":25,"phone":193,"phoneExt":7,"email":194},"Jing Wang","+86 13466379798","wangjing121@126.com",{"facility":196,"status":11,"city":197,"state":7,"zip":198,"country":14,"countryCode":15,"cosmosGeoPoint":199,"geoPoint":203,"contacts":204},"Army Medical Center of PLA","Chongqing","400010",{"type":17,"coordinates":200},[201,202],106.55771,29.56026,{"lat":202,"lon":201},[205],{"name":206,"role":25,"phone":207,"phoneExt":7,"email":208},"Gengze Wu, Doctor","+86-13996006248","wugengze@163.com",{"facility":210,"status":11,"city":211,"state":7,"zip":212,"country":14,"countryCode":15,"cosmosGeoPoint":213,"geoPoint":217,"contacts":218},"Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine","Shanghai","200080",{"type":17,"coordinates":214},[215,216],121.45806,31.22222,{"lat":216,"lon":215},[219],{"name":220,"role":25,"phone":221,"phoneExt":7,"email":222},"Yu Zhuang","+86 18917323250","drzhuangyu@163.com",{"type":224,"investigatorFullName":7,"investigatorTitle":7,"investigatorAffiliation":7,"oldNameTitle":7,"oldOrganization":7},"SPONSOR",[226,228,229,230,231,232,233,234,235,237,238,240,241,242],{"name":196,"class":227},"OTHER_GOV",{"name":114,"class":6},{"name":143,"class":6},{"name":128,"class":6},{"name":59,"class":6},{"name":44,"class":6},{"name":69,"class":6},{"name":173,"class":6},{"name":236,"class":6},"Fujian Provincial Hospital",{"name":210,"class":6},{"name":239,"class":6},"The Affiliated Hospital of Qingdao University",{"name":29,"class":6},{"name":84,"class":6},{"name":186,"class":6},"100613478","cohort-observing-mechanisms-progression-and-sequelae-of-valvular-heart-disease-100613478",false,"NCT07267117","Cohort Observing Mechanisms, Progression and Sequelae of Valvular Heart Disease","Cohort Observing Mechanisms, Progression and Sequelae of Valvular Heart Disease (VALVE-COMPASS)","VALVE-COMPASS","Inclusion Criteria:\n\n* At least 18 years old;\n* Be willing and able to provide informed consent to participate in the study;\n* Patients with heart valve disease diagnosed by echocardiography who meet one of the following criteria:\n\n  1. Grade II or higher Aortic valve regurgitation: regurgitant jet width \\>3 mm, jet width \u002F LVOT diameter ≥25%, jet cross-sectional area\u002FLVOT cross-sectional area ≥5%, effective regurgitant orifice area (EROA) ≥0.1 cm², regurgitant volume per beat (R Vol)≥30 ml, or regurgitant fraction (RF) ≥30%.\n  2. Moderate or higher aortic valve stenosis: peak velocity ≥3.0 m\u002Fs, Mean gradient ≥20 mm Hg, aortic valve area ≤1.5 cm², Indexed aortic valve area ≤0.85 cm²\u002Fm², or velocity ratio ≤0.50.\n  3. Grade II or higher mitral valve regurgitation: regurgitant jet width ≥3 mm, regurgitant volume per beat ≥30 ml, regurgitant jet area\u002Fleft atrial area \\>30%, or effective regurgitant orifice area (EROA) ≥0.2 cm².\n  4. Moderate or higher valve stenosis: valve area (specific finding) ≤1.5 cm², or mean gradient (supportive finding) ≥10.0 mmHg.\n  5. Grade II or higher tricuspid valve regurgitation: regurgitant jet width ≥3 mm, proximal isovelocity surface area ≥6 mm, effective regurgitant orifice area (EROA) ≥0.2 cm², or regurgitant volume per beat ≥30 ml.\n  6. Significant tricuspid valve stenosis: mean pressure gradient ≥5.0 mmHg, inflow time-velocity integral \\>60 cm, T1\u002F2 ≥190 ms, or valve area ≤1.0 cm².\n  7. Grade II or higher pulmonary valve regurgitation: regurgitant jet width \\>3 mm, regurgitant volume per beat ≥30 ml, regurgitant fraction ≥30%, or effective regurgitant orifice area (EROA) ≥0.1 cm².\n  8. Moderate or higher Pulmonary valve stenosis: pulmonary valve transvalvular pressure gradient ≥40 mmHg, right ventricular systolic pressure ≥60 mmHg, or pulmonary valve opening \\\u003C1.5 cm².\n\nExclusion Criteria:\n\n* Patients who are unwilling to accept registration and follow-up;\n* Patients who cannot cooperate with information collection and follow-up due to mental illness or other conditions;\n* Patients whose life expectancy is less than 12 months due to non-cardiac diseases (such as cancer, liver disease, kidney disease, or end-stage lung disease).","ALL","18 Years",{"count":254,"type":255},10000,"ESTIMATED","OBSERVATIONAL","The objective of this study is to evaluate and predict the progression of moderate cardiac valve stenosis and regurgitation using clinical, biological, echocardiographic, computed tomography (CT), and magnetic resonance imaging (MRI) data. Additionally, the study aims to analyze the potential impact of device-based interventions, pharmacological therapy, and lifestyle modifications on disease progression.",[259,260,261,262,263,264,265,266,267,268,269,270,271,272],"Heart Valve Disease","Mitral Valve (MV) Regurgitation","Mitral Valve Disease","Mitral Valve Stenosis","Aortic Valve Disease","Aortic Valve Stenosis","Tricuspid Valve Disease","Tricuspid Valve Regurgitation","Aortic Valve Regurgitation","Pulmonary Valve Disease","Transcatheter Valve Replacement","Transcatheter Aortic Valve Replacement (TAVR)","Transcatheter Pulmonary Valve Replacement (TPVR)","Transcatheter Edge-to-edge Repair",[274,275],"Heart Valve Disease Progression","Heart Valve disease sequelae","2025-11-25",{"date":278,"type":279},"2025-12-05","ACTUAL",{"date":281,"type":279},"2025-06-01",{"date":283,"type":255},"2030-05-31",{"name":5,"class":6},15]