[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100270533":3},{"organization":4,"armGroups":7,"interventions":7,"overallOfficials":8,"centralContacts":12,"locations":18,"responsibleParty":41,"collaborators":7,"id":44,"slug":45,"hasResults":46,"nctId":47,"briefTitle":48,"officialTitle":49,"acronym":50,"eligibilityCriteria":51,"healthyVolunteers":46,"sex":52,"minAge":53,"maxAge":7,"enrollmentInfo":54,"targetDuration":7,"studyType":57,"phases":7,"briefSummary":58,"conditions":59,"keywords":7,"overallStatus":21,"whyStopped":7,"lastUpdateSubmitDate":61,"lastUpdatePostDateStruct":62,"startDateStruct":65,"completionDateStruct":67,"leadSponsor":69,"locationsCount":70},{"fullName":5,"class":6},"Groupe Hospitalier Diaconesses Croix Saint-Simon","OTHER",null,[9],{"name":10,"affiliation":5,"role":11},"VALERIE ZELLER, Doctorate","PRINCIPAL_INVESTIGATOR",[13],{"name":14,"role":15,"phone":16,"phoneExt":7,"email":17},"YOUNES KERROUMI, Doctorate","CONTACT","(+33) 1 64 44 33 84","ykerroumi@hopital-dcss.org",[19],{"facility":20,"status":21,"city":22,"state":23,"zip":24,"country":25,"countryCode":26,"cosmosGeoPoint":27,"geoPoint":32,"contacts":33},"Groupe Hospitalier Diaconesses Croix Saint Simon","RECRUITING","Paris","Île-de-France Region","75020","France","FR",{"type":28,"coordinates":29},"Point",[30,31],2.3488,48.85341,{"lat":31,"lon":30},[34,37],{"name":35,"role":15,"phone":36,"phoneExt":7,"email":17},"Younes KERROUMI, Doctorate","(+33)1 44 64 33 84",{"name":38,"role":15,"phone":39,"phoneExt":7,"email":40},"Valérie ZELLER, Doctorate","(+33)1 44 64 17 80","vzeller@hopital-dcss.org",{"type":11,"investigatorFullName":42,"investigatorTitle":43,"investigatorAffiliation":5,"oldNameTitle":7,"oldOrganization":7},"Dr Valerie ZELLER","infectious diseases specialist","100270533","cohort-of-prosthetic-joint-infections-100270533",false,"NCT02801253","Cohort of Prosthetic Joint Infections","Prospective Cohort of Patients With Prosthetic Joint Infection","COPINS","Inclusion Criteria:\n\n* Patient aged over 18 years old with hip, knee and or shoulder joint prosthesis who consented to participate in the study with:\n* According to musculoskeletal infection society definition: PJI is present when one of the major criteria exists or four out of six minor criteria.\n\nMajor Criteria:\n\n* Two positive periprosthetic cultures with phenotypically identical organisms, OR\n* A sinus tract communicating with the joint, OR\n\nMinor Criteria:\n\n* Elevated serum C-reactive protein (CRP) AND erythrocyte sedimentation rate (ESR)\n* Elevated synovial fluid white blood cell (WBC)\n* Elevated synovial fluid polymorphonuclear neutrophil percentage (PMN%)\n* The presence of pus in the joint without known cause\n* Positive histological analysis of periprosthetic tissue\n* A single positive culture\n\nOr a PJI which meets the following three criteria:\n\n* Medical story suggesting prosthetic joint infection.\n* The presence of pain either with or without swelling for more than 3 months unrelated to a mechanical cause.\n* Germ identification in a single sample of fluid aspiration or tissue culture.\n\n  * Or microbial growth in prosthesis sonication fluid culture greater than 50CFU\u002Fml.\n\nExclusion Criteria:\n\n* Patient who does not meet eligibility criteria.\n* Patient lawfully deprived of his liberty.\n* Patient not insured under social security scheme.","ALL","18 Years",{"count":55,"type":56},800,"ESTIMATED","OBSERVATIONAL","Management of prosthetic joint infections (PJI) is a challenging task. These infections include different clinical and microbiological settings calling upon various treatment strategies according to infection type (acute or chronic), bone quality, the involved micro-organism and the patient's general condition and willing.\n\nTreatment of PJI combines surgery and prolonged antibiotic therapy. In some patients with a high operative risk prolonged suppressive antibiotic therapy can be used.\n\nLack of large prospective studies motivated the conception of this cohort with a long term follow up, regardless to PJI management procedures.",[60],"Prosthetic Joint Infection","2022-03-28",{"date":63,"type":64},"2022-03-29","ACTUAL",{"date":66,"type":64},"2015-09-11",{"date":68,"type":56},"2029-09",{"name":5,"class":6},1]