[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100643371":3},{"organization":4,"armGroups":7,"interventions":14,"overallOfficials":20,"centralContacts":24,"locations":33,"responsibleParty":49,"collaborators":10,"id":51,"slug":52,"hasResults":53,"nctId":54,"briefTitle":55,"officialTitle":56,"acronym":57,"eligibilityCriteria":58,"healthyVolunteers":53,"sex":59,"minAge":60,"maxAge":10,"enrollmentInfo":61,"targetDuration":10,"studyType":64,"phases":10,"briefSummary":65,"conditions":66,"keywords":68,"overallStatus":73,"whyStopped":10,"lastUpdateSubmitDate":74,"lastUpdatePostDateStruct":75,"startDateStruct":78,"completionDateStruct":80,"leadSponsor":82,"locationsCount":83},{"fullName":5,"class":6},"Beijing Anzhen Hospital","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"Off-Pump Coronary Artery Bypass Grafting Cohort",null,"Patients undergoing off-pump coronary artery bypass grafting who will receive preoperative cognitive assessment and postoperative follow-up for postoperative cognitive dysfunction. Perioperative clinical information, including preoperative assessment data, intraoperative monitoring parameters, and postoperative clinical data, will be collected.",[13],"Procedure: Off-Pump Coronary Artery Bypass Grafting",[15],{"type":16,"name":17,"description":18,"armGroupLabels":19,"otherNames":10},"PROCEDURE","Off-Pump Coronary Artery Bypass Grafting","Off-pump coronary artery bypass grafting is performed as part of routine clinical care for patients with coronary artery disease. The study protocol does not assign participants to this procedure or to any additional intervention. This observational study will collect perioperative clinical data and follow patients after surgery to assess postoperative cognitive dysfunction.",[9],[21],{"name":22,"affiliation":5,"role":23},"Wenjun Liu, PhD","PRINCIPAL_INVESTIGATOR",[25,29],{"name":22,"role":26,"phone":27,"phoneExt":10,"email":28},"CONTACT","+86 13811258408","lwjchina@163.com",{"name":30,"role":26,"phone":31,"phoneExt":10,"email":32},"Xuefei Jia, phD","+86 13121380377","jiaxuefei0320@163.com",[34],{"facility":35,"status":10,"city":36,"state":37,"zip":38,"country":39,"countryCode":40,"cosmosGeoPoint":41,"geoPoint":46,"contacts":47},"Beijing Anzhen Hospital, Capital Medical University","Beijing","Beijing Municipality","100029","China","CN",{"type":42,"coordinates":43},"Point",[44,45],116.39723,39.9075,{"lat":45,"lon":44},[48],{"name":22,"role":26,"phone":27,"phoneExt":10,"email":28},{"type":50,"investigatorFullName":10,"investigatorTitle":10,"investigatorAffiliation":10,"oldNameTitle":10,"oldOrganization":10},"SPONSOR","100643371","cohort-study-of-postoperative-cognitive-dysfunction-after-off-pump-coronary-artery-bypass-grafting-100643371",false,"NCT07643194","Cohort Study of Postoperative Cognitive Dysfunction After Off-Pump Coronary Artery Bypass Grafting","Risk of Postoperative Cognitive Dysfunction After Off-Pump Coronary Artery Bypass Grafting: A Prospective Cohort Study","OPCAB-POCD","Inclusion Criteria:\n\n* Age 18 years or older\n* Scheduled to undergo elective off-pump coronary artery bypass grafting\n* American Society of Anesthesiologists physical status classification I to IV\n* Able to complete preoperative cognitive assessments, including the Mini-Mental State Examination and the Montreal Cognitive Assessment\n* Written informed consent provided by the patient or family member\n\nExclusion Criteria:\n\n* Emergency surgery\n* Pre-existing diagnosed cognitive impairment or history of psychiatric disease\n* Preoperative cognitive impairment\n* Severe neurological disease, such as sequelae of stroke, that may interfere with cognitive assessment\n* Severe visual or hearing impairment that prevents completion of cognitive assessment\n* Inability to understand Chinese or presence of language communication barriers","ALL","18 Years",{"count":62,"type":63},600,"ESTIMATED","OBSERVATIONAL","This prospective cohort study aims to investigate postoperative cognitive dysfunction in patients undergoing off-pump coronary artery bypass grafting. Eligible patients will be enrolled before surgery and followed after surgery. Cognitive function will be assessed using the Montreal Cognitive Assessment before surgery and at predefined postoperative time points. Perioperative clinical information, including preoperative assessment data, intraoperative monitoring parameters, and postoperative clinical data, will be collected. The study will evaluate the occurrence of postoperative cognitive dysfunction and explore its association with perioperative factors.",[67],"Postoperative Cognitive Dysfunction (POCD)",[69,17,70,71,72],"Postoperative Cognitive Dysfunction","OPCABG","Montreal Cognitive Assessment","Prospective Cohort Study","NOT_YET_RECRUITING","2026-06-09",{"date":76,"type":77},"2026-06-11","ACTUAL",{"date":79,"type":63},"2026-05-24",{"date":81,"type":63},"2026-12-15",{"name":5,"class":6},1]